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Beziehungen zwischen den Endothelzellen der Lebersinusoide und den von Kupfferschen Sternzellen Elektronenmikroskopische Untersuchung

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Summary

Zymosan given to rats, normal or splenectomized, stimulates the RES of the liver. Under this stimulation, the endothelial cells of the sinusoids change into Kupffer cells. The endothelial cells become hypertrophic and multiply; they acquire progressively the properties of phagocytosis and of digestion shown by the Kupffer cells. Hence both types of cells — the endothelial and the Kupffer cells — belong to the same cellular lineage. Their various aspects result from different functional states.

The hyperplasia of the liver RES has no repercussion on the fine structure of the hepatic cells.

Résumé

L'administration de Zymosan à des rats, splénectomisés ou non, provoque une stimulation du SRE du foie. Sous l'effet de cette stimulation, les cellules endothéliales des sinusoïdes se transforment en cellules de Kupffer. Les cellules endothéliales s'hypertrophient et se multiplient; progressivement, elles acquiérent les propriétés de phagocytose et de digestion des cellules de Kupffer. Les deux types de cellules — endothéliales et cellules de Kupffer — appartiennent donc bien à la même lignée cellulaire. Leurs divers aspects correspondent à des états fonctionnels différents.

L'hyperplasie du SRE du foie n'a pas de répercussion sur l'ultrastructure des hépatocytes.

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Authors and Affiliations

  1. Institut für normale Histologie und Embryologie der Universität Genf, Schweiz

    P. Nicolescu &  Ch. Rouiller

  2. Institut d'Histologie, Ecole de Médecine, 20, Rue de l'Ecole de Médecine, 1211, Geneve 4, Suisse

    Ch. Rouiller

  3. Institut d'Oncologie, Bucarest, Roumanie

    P. Nicolescu

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Mit Unterstützung durch den Schweizerischen Nationalfond für die Förderung der Wissenschaftlichen Forschung.

Stipendiat der Organisation Mondiale de la Santé.

Übersetzung von Frau Antje Forssmann, technische Mitarbeit von Max Baumann, Michel Bernard und Charles Moreillon.

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Nicolescu, P., Rouiller, C. Beziehungen zwischen den Endothelzellen der Lebersinusoide und den von Kupfferschen Sternzellen Elektronenmikroskopische Untersuchung. Zeitschrift für Zellforschung 76, 313–338 (1967). https://doi.org/10.1007/BF00339291

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