Zusammenfassung
Osmotische Nephrosen wurden durch intraperitoneale Injektionen von Saccharose bzw. Glukose erzeugt. Bei den meisten der untersuchten weißen Mäuse findet man in den hellen Zellen der Pars proximalis der Sammelrose dunkle Einschlüsse von besonderem Aussehen. Diese Einschlüsse enthalten eine lamellenartige Innenstruktur, welche an Dispersionen von Lecithin oder Lecithin-Cholesterin in elektronenoptischen Aufnahmen nach „negative staining“ erinnern. Diese Einschlüsse der Sammelrohrzellen stehen wahrscheinlich zu der Funktion der Reabsorption in Beziehung; sie gehören nach unserer Auffassung mit den Residualkörpern (residual body) zur Gruppe der Lysosomen.
Summary
Osmotic nephrosis was induced in mice by intraperitoneal injections of a solution of sucrose or glucose. In most of the animals, the pale cells of the initial segment of the collecting tubules contain extremely peculiar dense granules. These inclusions contain lamellar systems of which the appearance closely resembles that of lecithine-cholesterol dispersions, as observed with an electron microscope after negative staining. These inclusions, which are probably related with the resorbtive function of the pale cells, are considered as residual bodies, and classified as belonging to the lysosome family.
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Ce travail a partiellement bènèficiè de l'aide du Fonds National Suisse de la Recherche Scientifique et de la contribution du «Consiglio Nazionale délie Ricerche», Italie.
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Melis, M., Orci, L. Inclusions cytoplasmiques lamellaires dans les tubes collecteurs du rein au cours de la néphrose osmotique. Zeitschrift für Zellforschung 77, 425–434 (1967). https://doi.org/10.1007/BF00339245
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DOI: https://doi.org/10.1007/BF00339245