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Mitosis and degeneration in the morphogenesis of the human foetal lung in vitro

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Summary

Observations of organ cultures of human foetal lung show that the morphogenesis of the bronchial tree is brought about by mitosis, cell death and cell migration. The same phenomena can be seen in vivo when the rate of morphogenesis is rapid. The lungs expand by the bifurcation of terminal pneumonomeres and by lateral budding proximal to the terminal tips. The interaction of epithelial and mesenchymal elements is discussed.

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References

  • Alescio, T., and A. Cassini: Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J. exp. Zool. 150, 83–94 (1962a).

    PubMed  Google Scholar 

  • —, and A. Cassini: Osservazioni preliminari sulla riassociazione in vitro dell'epitelio e del mesenchima del polmone embrionale di topo. Atti Soc. ital. Anat. 21, Suppl. al vol. 70 del Monit. Zool. Ital., 97–103 (1962b).

    Google Scholar 

  • —, and A. Cassini: L'Interazione epitelio-mesenchimale nell'organogenesi del polmone embrionale di topo coltivato in vitro. Z. Anat. Entwickl.-Gesch. 123, 369–396 (1962c).

    Google Scholar 

  • Bender, K. W.: Über die Entwicklung der Lungen. Z. Anat. Entwickl.-Gesch. 75, 639–652 (1925).

    Google Scholar 

  • Borghese, E.: The effect of ionizing radiations on mouse embryonic lungs developing in vitro. Ann. N.Y. Acad. Sci. 95, 866–872 (1961).

    PubMed  Google Scholar 

  • Dameron, F.: L'Influence de divers mésenchymes sur la différenciation de l'épithélium pulmonaire de l'embryon de poulet en culture in vitro. J. Embryol. exp. Morph. 9, 628- 633 (1961).

    PubMed  Google Scholar 

  • Frank, G. M.: Über Gesetzmäßigkeiten in der Mitoseverteilung in den Gehirnblasen im Zusammenhang mit Formbildungsprozessen. Wilhelm Roux' Arch. Entwickl.-Mech. Org. 104, 262–272 (1925).

    Google Scholar 

  • Glucksmann, A.: Über die Bedeutung von Zellvorgängen für die Formbildung epithelialer Organe. Z. Anat. Entwickl.-Gesch. 93, 35–92 (1930).

    Google Scholar 

  • —: Development and differentiation of the tadpole eye. Brit. J. Ophthal. 24, 153–178 (1940).

    Google Scholar 

  • —: Cell deaths in normal vertebrate ontogeny. Biol. Rev. 26, 59–86 (1951).

    Article  Google Scholar 

  • Grover, J. W.: The relation between the embryonic age of dissociated chick lung cells and their capacity for reaggregation and histogenesis in vitro. Exp. Cell Res. 24, 171–173 (1961).

    PubMed  Google Scholar 

  • —: The enzymatic dissociation and reproducible reaggregation in vitro of 11-day embryonic chick lung. Develop. Biol. 3, 555–568 (1961).

    PubMed  Google Scholar 

  • Gurwitsch, A.: Der Vererbungsmechanismus der Form. Wilhelm Roux' Arch. Entwickl.- Mech. Org. 39, 516–577 (1914).

    Google Scholar 

  • —: Das Problem der Zellteilung physiologisch betrachtet. Berlin: Springer 1926.

    Google Scholar 

  • Heidenhain, M.: Über die teilungsfähigen Drüseneinheiten oder Adenomeren sowie über die Grundbegriffe der morphologischen Systemlehre. Berlin 1921.

  • —: Formen und Kräfte in der lebendigen Natur. Vortr. Entw. Mech. Org. 32, 1 (1923).

    Google Scholar 

  • Lasnitzki, I.: The effect of 3–4 benzpyrene on human foetal lung grown in vitro. Brit. J. Canc. 10, 510–516 (1956).

    Google Scholar 

  • —: Observations on the effects of condensates from cigarette smoke on human foetal lung in vitro. Brit. J. Cancer 12, 547–552 (1958).

    PubMed  Google Scholar 

  • Loffredo Sampaolo, C., e G. Sampaolo: Indagini sperimentali sullo sviluppo del polmone embrionale (pollo e coniglio). Quad. Anat. prat. 17, 1–43 (1961).

    Google Scholar 

  • Miale, I. L., and R. D. Sidman: An autoradiographic analysis of histogenesis in the mouse cerebellum. Exp. Neurol. 4, 277–296 (1961).

    Article  PubMed  Google Scholar 

  • Sauer, M. E., and B. E. Walker: Radioautographic study of interkinetic nuclear migration in the neural tube. Proc. Soc. exp. Biol. (N.Y.) 101, 557–560 (1959).

    Google Scholar 

  • Sidman, R. L.: Histogenesis of mouse retina studied with thymidine-H3. In: Structure of the eye, G. Smelser Ed., p. 487–506. New York: Academic Press 1961.

    Google Scholar 

  • Wassermann, F.: Wachstum und Vermehrung der lebendigen Masse. In: Handbuch der mikroskopischen Anatomie des Mensehen, V. Möllendorff, ed., vol. 1, part 2. Berlin: Springer 1929.

    Google Scholar 

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Authors and Affiliations

  1. Strangeways Research Laboratory, Cambridge, England

    Alfred Glucksmann

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  1. Alfred Glucksmann
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Dedicated to Professor Friedrich Wassermann with admiration and affection on the occasion of his eightieth birthday.

Working with a grant from the British Empire Cancer Campaign for Research.

I wish to record my indebtedness to Professor Dame Honor Fell and to Dr. Ilse Lasnitzki for their constructive criticism of the manuscript and to Mr. G. C. Lenney for the illustrations.

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Glucksmann, A. Mitosis and degeneration in the morphogenesis of the human foetal lung in vitro . Z.Zellforsch 64, 101–110 (1964). https://doi.org/10.1007/BF00339189

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  • DOI: https://doi.org/10.1007/BF00339189

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