Abstract
The transmission of donor-related malignancies by organ transplantation is a rather rare event. There has only been one report on the development of a brain tumor metastasis in liver transplantation. From September 1988 to January 1993, 342 donor hepatectomies with subsequent transplantation were performed at our center. The main donor diagnoses included subarachnoidal bleeding (n=128; 37.4%), isolated head injury (n=114; 33.3%), multiple injuries (n=55; 16.1%), primary cerebral neoplasia (n=13; 3.8%), and other (n=32; 9.4%). Primary cerebral neoplasia included glioblastoma (n=4), meningioma (n=3), astrocytoma (n=2), angioma (n=2), neurocytoma (n=1), and ependymoma (n=1). In the group of donors suffering from primary cerebral neoplasia, procured organs other than the liver included kidneys (n=20), combined kidneys and pancreata (n=1), pancreata (n=2) hearts (n=8), combined hearts and lungs (n=1), and single lungs (n=1). Follow-up of the respective graft recipients ranged from 28 to 68 months (median 43 months). Recurrent malignancy was observed once, in a liver graft recipient. The donor, a 48-year-old female, had undergone surgical resection of an intracerebral multiform glioblastoma and died 4 months later of a relapse in the brain stem. The 28-year-old female recipient had undergone transplantation for an autoimmune-hepatitic cirrhosis. Four months later, histopathological examination of an intraperitoneal and intrahepatic mass revealed a poorly differentiated, small-cell pleomorphic cancer, identified as a glioma metastasis by S100-and glial fibrillary acidic protein immunohistochemical staining. The patient died 6 months post-transplantation. On autopsy, no further neoplastic lesions were detected. Our review adds a second reported case of a liver graft-transmitted brain tumor to the literature and the fourth donor-related malignancy after hepatic transplantation in general.
References
Baquero A, Foote J, Kottle S, Raja R, Mendez M, Noumoff J, Cavarocchi N, Cohn JB, Bannett AD (1988) Inadvertent transplantation of choriocarcinoma into four recipients Transplant Proc 20: 98–100
Baquero A, Penn I, Bannett A, Werner DJ, Kim P (1988) Misdiagnosis of metastatic cerebral choriocarcinoma in female cadaver donors. Transplant Proc 20: 776–777
Hoffmann HJ, Duffner PK (1985) Extraneural metastases of central nervous system tumors. Cancer 56: 1778–1782
Jackson AM, Graham DI (1978) Remote metastases from intracranial tumours. J Clin Pathol 31: 794–802
Kimura T, Budka H, Soler-Federspiel S (1986) An immunohistochemical comparison of the glia-associated proteins, glial fibrillary acidic protein (GFAP), and S-100 protein (S-100P) in human brain tumors. Clin Neuropathol 5: 21–27
Lefrancois N, Touraine JL, Cantarovich D, Cantarovich F, Faure JL, Dubernard JM, Dureau G, Colpart JJ, Bouvier R, Traeger J (1987) Transmission of medulloblastoma from cadaver donor to three organ transplant recipients. Transplant Proc 19: 2242
Leifer D, Moore T, Ukena T, Wilner D, Thor A, Hedley-White ET (1989) Multifocal glioblastoma with liver metastases in the absence of surgery: case report. J Neurosurg 71: 772–776
Morse JH, Turcotte JG, Merion R, Campbell DA Jr, Burtch GD, Lucey MR (1990) Development of a malignant tumor in a liver transplant graft procured from a donor with a cerebral neoplasm. Transplantation 50: 875–877
Neuhaus P, Bechstein WO, Blumhardt G, Wiens M, Lemmens P, Langrehr JM, Lohmann R, Steffen R, Schlag H, Slama KJ, Lobeck H (1993) Comparison of quadruple immunosuppression after liver transplantation with ATG or IL-2 receptor antibody. Transplantation 55: 1320–1327
Neuhaus P, Blumhardt G, Bechstein WO, Steften R, Platz KP, Keck H (1994) Technique and results of biliary reconstruction using side-to-side choledoch-ocholedochostomy in 300 orthotopic liver transplants. Ann Surg 219: 426–434
Pasquier B, Pasquier D, N'Golet A, Panh MH, Coudere P (1980) Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of the literature. Cancer 45: 112–125
Penn I (1991) Donor transmitted disease: cancer. Transplant Proc 23: 2629–2631
Penn I (1993) Malignancy in transplanted organs. Transpl Int 6: 1–3
Perentes E, Rubinstein LJ (1987) Recent application of immunoperoxidase histochemistry in human neuro-oncology. Arch Pathol Lab Med 111: 796–812
Spiro IJ, Yandell DW, Li C, Saini S, Ferry J, Powelson J, Katkov WN, Cosimi AB (1993) Brief report: lymphoma of donor origin occurring in the porta hepatis of a transplanted liver. N Engl J Med 329: 27–29
Zimmermann HM (1957) The natural history of intracranial neoplasms with special reference to the gliomas. Am J Surg 93: 913–924
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Jonas, S., Bechstein, W.O., Lemmens, HP. et al. Liver graft-transmitted glioblastoma multiforme. A case report and experience with 13 multiorgan donors suffering from primary cerebral neoplasia. Transpl Int 9, 426–429 (1996). https://doi.org/10.1007/BF00335707
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DOI: https://doi.org/10.1007/BF00335707