Skip to main content
SpringerLink
Log in

On the prediction of epileptic seizures

  • Published:
Biological Cybernetics Aims and scope Submit manuscript

Abstract

In 12 epileptic patients suffering from “absences” 8-channel EEG was recorded by telemetry. The autoregressive model was applied to the signal and the prediction coefficients being the basis for calculation of the poles of the predictor. The location of the poles in thez- ands-planes was described as a function of time for 0.1 s steps along the pre-seizure EEG. In 10 of the 12 patients, and in 25 of the 28 recorded seizures this presentation of the poles of the predictor showed specific pattern linked with the occurrence of the siezure. The trajectory of the “most mobile pole” during the pre-seizure period could aid in the prediction of the seizure by several seconds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Best, W.R.: Drug associated blood discrasias. J. Am. Med. Assoc.185, 286–290 (1974)

    Google Scholar 

  • Cook, C.E., Christensen, H.D., Amerson, E.W., Kepler, J.A., Tallent, C.R. Taylor, G.F.: Radioimmunoassay of anticonvulsant drugs. In: Quantitative analytic studies in epilepsy. pp. 39–58. Kellaway, P., Petersen, I. (eds.). New York: Raven Press 1976

    Google Scholar 

  • Cooper, R., Winter, A.L., Crow, H.J., Walter, W.G.: Comparison of subcortical, cortical, and scalp activity using chronically indwelling electrodes in man. Electroencephalogr. Clin. Neurophysiol.18, 217–228 (1965)

    Google Scholar 

  • Cooper, I.S., Amin, I., Gilman, S.: The effect of chronic cerebellar stimulation upon epilepsy in man. Trans. Am. Neurol. Assoc.98, 192–194 (1973)

    Google Scholar 

  • Da Silva, L., Hokes, A., Smits, H., Zetterberg, L.H.: Model of brain rhythmic activity. Kybernetik15, 27–37 (1974)

    Google Scholar 

  • Da Silva, L., Dijk, A., Smits, H.: Detection of nonstationarities in EEG's using the autoregressive model — an application to EEG's of epileptics. In: Computerized EEG analysis. Dolce, G., Künkel, H. (eds.) Stuttgart, New York: Gustav Fischer, pp. 180–199 (1975)

    Google Scholar 

  • Fernandez-Guardiola, A., Alcaraz, V.M., Guzman, F.C.: Inhibition of convulsive activity in the reticular formation. Acta Neurol. Latinoam.7, 30–36 (1961)

    Google Scholar 

  • Gersch, W.: Spectral analysis of EEG's by autoregressive decomposition of time series. Math. Biosci.7, 205–222 (1970)

    Google Scholar 

  • Gersch, W., Tharp, B.R.: Spectral regression — amount of information analysis of seizures in humans. In: Quantitative analytic studies in epilepsy. pp. 509–532. Kellaway, P., Petersen, I. (eds.). New York: Raven Press 1976

    Google Scholar 

  • Ishijima, B., Mori, T., Yoshimasu, N.: Neuronal activities in human epileptic foci and surrounding areas. Electroencephal. Clin. Neurophysiol.39, 643–650 (1975)

    Google Scholar 

  • Kaplan, B.J.: Biofeedback in epileptics: equivocal relationship of enforced EEG frequency to seizure reduction. Epilepsia16, 477–485 (1975)

    Google Scholar 

  • Kreindler, A.: Experimental epilepsy. Progr. Brain Res.19, 160–167 (1965)

    Google Scholar 

  • Kuhlman, W.N., Allison, T.: EEG feedback training in the treatment of epilepsy: some questions and some answers. Pavlovian J. Biol. Sci.12, 112–122 (1977)

    Google Scholar 

  • Makhoul, J.: Linear prediction: a tutorial review. Proc. IEEE63, 561–580 (1975)

    Google Scholar 

  • Reynolds, E.H.: Effects of folic acid on the mental state and fit frequency of drug treated epileptic patients. Lancet1, 1086–1088 (1967)

    Google Scholar 

  • Roth, S.R., Sterman, M.B., Clements, C.D.: Comparison of EEG correlates of reinforcement. Internal inhibition of sleep. Electroencephalogr. Clin. Neurophysiol.23, 509–520 (1967)

    Google Scholar 

  • Sterman, M.B.: Sensorimotor EEG conditioning: experimental and clinical effects. Pavlovian J. Bio. Sci.12, 63–92 (1977)

    Google Scholar 

  • Upton, A.R.M., Longmire, D.: The effects of feedback on focal epileptic discharge in man. Can. J. Neurol. Sci.48, 153–167 (1975)

    Google Scholar 

  • Wyrwicka, W., Sterman, M.B.: Instrumental conditioning of sensorimotor cortex EEG spindles in the waking cat. Physiol. Behav.3, 703–707 (1968)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering and Department of Clinical Neurophysiology, Technion, Haifa, Israel

    Z. Rogowski, I. Gath & E. Bental

Authors
  1. Z. Rogowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Gath
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Bental
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dr. Isak Gath c/o Prof. Lehmann Neurologische Universitätsklinik CH-8091 Zürich Switzerland

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rogowski, Z., Gath, I. & Bental, E. On the prediction of epileptic seizures. Biol. Cybern. 42, 9–15 (1981). https://doi.org/10.1007/BF00335153

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00335153

Keywords

Search

Navigation