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Alterations of the mineralization profile and osteocalcin concentrations in osteoarthritic cortical iliac crest bone

  • Clinical Investigations
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Summary

The relation between bone mineralization and osteocalcin content was investigated in iliac crest cortical bone obtained at necropsy in young females and in two groups of elderly women with and without osteoarthritis of the hands evaluated by X-ray. Using density fractionation technique, the bone was separated into fractions of increasing density from 1.72 to 2.30 g/ml. The mineralization profile revealed a significant shift to higher densities in the osteoarthritis cases compared with young adults (P<0.005) and age-sexmatched controls (P<0.001). The ash, calcium, and phosphorus content of the bone increased with increasing density of the fractions whereas collagen content, measured as hydroxyproline, decreased. The osteocalcin concentration of each fraction was determined in the supernatants obtained after EDTA-extraction in the presence of protease inhibitors. In the young control and osteoarthritis group, the osteocalcin content in the lowest density fractions was higher compared with the older non-osteoarthritic group. Osteocalcin content of the high density fractions, representing highly mineralized osteons, was the same in the three groups studied. These findings support the hypothesis that quality differences in bone may explain the inverse relationship between osteoarthritis and osteoporosis.

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Authors and Affiliations

  1. Arthritis and Metabolic Bone Disease Research Unit, Division of Rheumatology, K.U. Leuven, University Hospital Pellenberg, 3212, Pellenberg, Belgium

    Greet Raymaekers, Jeroen Aerssens, René Van den Eynde, Jenny Peeters, Piet Geusens & Jan Dequeker

  2. Department of Nuclear Medicine, K.U. Leuven, University Hospital Gasthuisberg, 3000, Leuven, Belgium

    Paul Devos

Authors
  1. Greet Raymaekers
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  2. Jeroen Aerssens
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  3. René Van den Eynde
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  4. Jenny Peeters
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  5. Piet Geusens
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  6. Paul Devos
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  7. Jan Dequeker
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Raymaekers, G., Aerssens, J., Van den Eynde, R. et al. Alterations of the mineralization profile and osteocalcin concentrations in osteoarthritic cortical iliac crest bone. Calcif Tissue Int 51, 269–275 (1992). https://doi.org/10.1007/BF00334486

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  • DOI: https://doi.org/10.1007/BF00334486

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