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Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype

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Summary

Analysis of G-banded prometaphase chromosomes from three XX males revealed extra bands on the distal end of one X short arm. These bands were similar both in size and staining properties to the distal Y short arm of their fathers (in the two cases examined) and also to other chromosomally normal males. The extra material on the abnormal X chromosomes was not C-or G-11 positive in the two cases examined, suggesting that the proximal Y long arm was not present.

Previous karyotype-phenotype correlations with structurally altered Y chromosomes provided evidence for localization of male determinants on the Y short arm. The present findings in XX males provide support for more precise localization, to bands p11.2→pter of Y short arm.

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Authors and Affiliations

  1. Department of Medical Genetics, Crippled Children's Division, Oregon Health Sciences University, 97201, Portland, OR, USA

    R. E. Magenis, D. Tomar, L. J. Allen & E. Lovrien

  2. Department of Health and Welfare, 83702, Boise, ID, USA

    M. J. Webb & R. S. McKean

  3. Providence Medical Center, 97213, Portland, OR, USA

    H. Kammer

  4. Henry Ford Hospital, 48202, Detroit, MI, USA

    D. L. Van Dyke

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  1. R. E. Magenis
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  2. M. J. Webb
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  3. R. S. McKean
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  4. D. Tomar
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  5. L. J. Allen
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  6. H. Kammer
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  7. D. L. Van Dyke
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  8. E. Lovrien
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Magenis, R.E., Webb, M.J., McKean, R.S. et al. Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype. Hum Genet 62, 271–276 (1982). https://doi.org/10.1007/BF00333535

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  • DOI: https://doi.org/10.1007/BF00333535

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