Summary
In a 30-year-old azoospermic male, chromosome analysis revealed an apparently balanced Y-autosome reciprocal translocation, t(Y;6)(Yp6p;Yq6q). Testicular biopsy showed an arrest of spermatogenesis at the First metaphase stage of the meiosis, associated with a considerable desquamation of the germinal epithelium.
Meiotic studies showed abnormalities of the sex vesicle at the pachytene stage, and the formation of a chain tetravalent at the diakinesis-metaphase I stage. Possible correlations between the translocation and the defects of spermatogenesis are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chandley AC, Seuanez H, Fletcher J (1976) Meiotic behaviour of five human reciprocal translocations. Cytogenet Cell Genet 17:98–111
Dutrillaux B, Descailleaux J, Viegas-Pequignot E, Couturier J (1981) Y-autosome translocation in Cacajao calvus rubicundus Platyrrhini. Ann Genet 24:197–201
Dutrillaux B, Gueguen J (1975) Etude meiotique et mitotique dans un cas de translocation t(5;Y). Humangenetik 27:241–245
Gonzales J, Lesourd L, Dutrillaux B (1981) Mitotic and meiotic analysis of a reciprocal translocation t(Y;3) in an azoospermic male. Hum Genet 57:111–114
Laurent C, Dutrillaux B (1976) Translocation t(Y;14) chez un homme azoospermique. Ann Genet 19:207–209
Léonard A, Deknudt G (1969) Etude cytologique d'une translocation chromosome Y-autosome chez la souris. Experientia 25:876–877
Ma NSF, Elliot MW, Morgan LM, Miller AC, Jones TC (1976) Translocation of Y chromosome to an autosome in the Bolivian owl monkey. Aotus. Am J Phys Anthropol 45:191–202
Ma NSF, Renquist DM, Hall R, Sehgal PK, Simeone T, Jones TC (1980) XX/“XO” sex determination system in a population of Peruvian owl monkey, Aotus. J Hered 71:336–342
Petit P, Unglik A, Fryns JP (1982) Translocation 46,X,t(Y;14)(q122; Q111) in a case of sterility in the male. Ann Genet 25:63–64
San Roman C, Sordo MT, Garcia-Sagredo JM (1979) Meiosis in two human reciprocal translocation. J Med Genet 16:56–59
Smith A, Fraser IS, Elliot G (1979) An infertile male with balanced Y;19 translocation. Review of Y; autosome translocations. Ann Genet 22:189–194
Templado C, Marina S, Coll MD, Egozcue J (1980) Meiotic studies in human semen. Report of 180 cases. Hum Genet 53:335–339
Viegas-Pequignot E, Dutrillaux B (1978) Une méthode simple pour obtenir des prophases et des prométaphases. Ann Genet 21:122–125
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Viguié, F., Romani, F. & Dadoune, J.P. Male infertility in a case of (Y;6) balanced reciprocal translocation. Mitotic and meiotic study. Hum Genet 62, 225–227 (1982). https://doi.org/10.1007/BF00333524
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00333524