Summary
Lymphocytosis of large granular lymphocytes (LGL) with severe neutropenia was diagnosed in a 42-years old patient. After prednisone yielded only a transistory effect, long lasting improvement was achieved by treatment with cyclosporin A.
References
Loughran TP Jr, Starkebaum G (1987) Large granular lymphocyte leukemia. Report of 38 cases and review of the literature. Medicine 66: 397–405
Loughran TP Jr, Kadin ME, Starkebaum G, Abkowitz JL, Clark EA, Disteche C, Lum LG, Slichter SJ (1985) Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia. Ann Intern Med 102: 169–175
Loughran TP Jr, Clark EA, Price TH, Hammond WP (1986) Adult onset-cyclic neutropenia is associated with increased large granular lymphocytes. Blood 68: 1082–1087
Ohno T, Kanoh T, Arita Y, Fujii H, Kuribayashi K, Masuda T, Horiguchi Y, Taniwaki N, Nosaka T, Hatanaka M, Uchino H (1988) Fulminant clonal expansion of large granular lymphocytes: characterization of their morphology, phenotype, genotype and function. Cancer 62: 1918–1927
Selleri C, Catalano L, Alfinito F, De Rosa G, Vaglio S, Rotoli B (1988) Cyclosporin A in adult-onset cyclic neutropenia. Br J Haematol 68: 137–138
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Pastor, E., Sayas, M.J. Severe neutropenia associated with large granular lymphocyte lymphocytosis: Successful control with cyclosporin A. Blut 59, 501–502 (1989). https://doi.org/10.1007/BF00329495
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DOI: https://doi.org/10.1007/BF00329495