Summary
The incidence of G6PD deficiency among 338 Thai males with senile cataracts was 5.92% while 446 control Thai males gave an incidence of 6.95%. The figures in females were 16.29% and 14% among 201 senile cataracts females and 200 control females respectively. The age of onset of senile cataracts was not different between the G6PD deficient and G6PD normal groups. The findings indicate that, at least in Thailand, G6PD deficiency in general is not a factor in cataractogenesis.
References
Bellows, J. G., Schock, D. E.: Alloxan diabetes and lens. Am. J. Ophthalmol. 33, 1555–1564 (1950)
Bernstein, R. E.: A rapid screening dye test for the detection of glucose-6-phosphate dehydrogenase deficiency in red cells. Nature 194, 192–193 (1962)
Beutler, E.: The glutathione instability of drug-sensitive red cells. A new method for the in vitro detection of drug-sensitivity. J. Lab. and Clin. Med. 49, 84–94 (1957)
Evelyn, K. A., Malloy, H. T.: Microdetermination of oxyhemoglobin, methemoglobin, and sulfhemoglobin in a single sample of blood. J. Biol. Chem. 126, 655–662 (1938)
Gall, J. C. Jr., Brewer, G. J., Dern, R. J.: Studies on glucose-6-phosphate dehydrogenase activity of individual erythrocytes: The methemoglobin elution test for identification of female heterozygous for G6PD deficiency. Amer. J. Hum. Genet. 17, 359–368 (1965)
Helge, H., Broner, K.: Kongenitale nichtsphaerozytaere haemolytische Anaemie, Katarakt und Glucose-6-Phosphat-dehydrogenase-mangel. Dtsch. Med. Wochenschr. 91, 1584–1590 (1966)
Panich, V.: G6PD characterization in Thailand (Abstract of paper presented at the Thirteenth International Congress of Genetics, Berkeley, California. August 20–29, 1973). Genetics 74, 208 (1973)
Panich, V., Sungnate, T.: Characterization of glucose-6-phosphate dehydrogenase in Thailand. The occurrence of 6 variants among 50 G6PD deficient Thai. Humangenetik 18, 39–46 (1973)
Tuchinda, S., Rucknagel, D. L., Na-Nakorn, S., Wasi, P.: The Thai variant and the distribution of alleles of 6-phosphogluconate dehydrogenase and the distribution of glucose-6-phosphate dehydrogenase deficiency in Thailand. Biochem. Genet. 2, 253–264 (1968)
Westring, D. W., Pisciotta, A. V.: Anemia, cataracts, and seizures in patient with glucose-6-phosphate dehydrogenase deficiency. Arch. Intern. Med. 118, 385–390 (1966)
Zinkham, W. H.: A deficiency of glucose-6-phosphate dehydrogenase activity in lens from individuals with primaquine-sensitive erythrocytes. Bull. Johns Hopkins Hosp. 109, 206–216 (1961)
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Panich, V., Na-Nakorn, S. G6PD deficiency in senile cataracts. Hum. Genet. 55, 123–124 (1980). https://doi.org/10.1007/BF00329138
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DOI: https://doi.org/10.1007/BF00329138