Summary
Computer-assisted methods of CT brain scan analysis offer considerable advantages over visual inspection, particularly in research; and several semi-automated methods are currently available. A new computer-assisted program is presented which provides fully automated processing of CT brain scans, depending on “anatomical knowledge” of where cerebrospinal fluid (CSF)-containing spaces are likely to lie. After identifying these regions of interest quantitative estimates are then provided of CSF content in each slice in cisterns, ventricles, Sylvian fissure and interhemispheric fissure. Separate measures are also provided of mean brain density in each slice. These estimates can be summated to provide total ventricular and total brain volumes. The program shows a high correlation with measures derived from mechanical planimetry and visual grading procedures, also when tested against a phantom brain of known ventricular volume. The advantages and limitations of the present program are discussed.
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References
Weinberger DR, Bigelow LB, Kleinman JE, Klein ST, Rosenblatt JE, Wyatt RJ (1979) Lateral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 36:735–739
Andreasen NC, Smith MR, Jacoby CG, Dennert JW, Olsen SA (1982) Ventricular enlargement in schizophrenia: definition and prevalence. Am J Psychiatry 139:292–296
Naguib M, Levy R (1982) Prediction of outcome in senile dementia — a computed tomography study. Br J Psychiatry 140: 263–267
Ron MA, Acker W, Shaw GK, Lishman WA (1982) Computerised tomography of the brain in chronic alcoholics: a survey and follow-up study. Brain 105:497–514
Ron MA (1983) The alcoholic brain: CT scan and psychological findings. Psychological Med [Monogr Suppl] 3
Penn RD, Belanger MG, Yasnoff WA (1978) Ventricular volume in man computed from CAT scans. Ann Neurol 3: 216–223
Sager WD, Gell G, Ladurner G, Ascher PW (1978) Calculation of cerebral tissue and cerebrospinal fluid space volumes from computer tomograms. Neuroradiology 16:176–178
Hacker H, Artmann H (1978) The calculation of CSF spaces in CT. Neuroradiology 16:190–192
Reveley AM, Reveley MA, Murray RM (1984) Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. Br J Psychiatry 144:89–93
Walser RL, Ackerman LV (1977) Determination of volume from computerised tomograms: finding the volume of fluidfilled brain cavities. J Comput Assist Tomogr 1:117–130
Heinrich G, Mai N, Backmund H (1979) Preprocessing in computed tomography picture analysis: a “bone-deleting” algorithm. J Comput Assist Tomogr 3:379–384
Keller JM, Edwards FM, Rundle R (1981) Automatic outlining of regions on CT scans. J Comput Assist Tomogr 5: 240–265
Jernigan TL, Zatz LM, Naeser MA (1979) Semiautomated methods for quantitating CSF volume on cranial computed tomography. Radiology 132:463–466
Zatz LM, Jernigan TL, Ahamuda AJ Jr (1982) Changes on computed cranial tomography with aging: intracranial fluid volume. Am J Neuroradiol 3:1–11
Synek V, Reuben JR (1976) The ventricular-brain ratio using planimetric measurement of EMI scans. Br J Radiol 49: 233–237
Lishman WA (1981) Cerebral disorder in alcoholism: syndromes of impairment. Shorvon Memorial Lecture. Brain 104: 1–20
Reveley MA (1985) Ventricular enlargement in schizophrenia: the validity of computerised tomographic finding. Br J Psychiatry 147:233–240
Jacobson RR, Turner SW, Baldy RE, Lishman WA (1985) Densitometric analysis of CT scans: important sources of artefact. Psychol Med 15:879–889
Williams G, Bydder GM, Kreel L (1980) The validity and use of computed tomography attenuation values. Br Med Bull 36: 279–287
Brooks RA, Keller MR, O'Connor CM, Sheridan WT (1980) Progress towards quantitative computed tomography. IEEE Trans Nucl Sci NS 27:1121–1127
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This work was supported by grants from the Medical Research Council
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Baldy, R.E., Brindley, G.S., Ewusi-Mensah, I. et al. A fully-automated computer-assisted method of CT brain scan analysis for the measurement of cerebrospinal fluid spaces and brain absorption density. Neuroradiology 28, 109–117 (1986). https://doi.org/10.1007/BF00327881
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DOI: https://doi.org/10.1007/BF00327881