Skip to main content
SpringerLink
Log in

Familial translocation involving chromosome 6, 14 and 20, identified by quinacrine fluorescence

  • Original Investigations
  • Published:
Humangenetik Aims and scope Submit manuscript

Summary

A 4 year old girl with physical and mental retardation but few other abnormalities was found to have an unbalanced karyotype, 47,XX,6-,t(6q,20p?)+,t(14q,6q)+, resulting in partial trisomy-14. This arose by aberrant segregation of chromosomes during meiosis in her mother, who has a complex translocation involving chromosomes 6, 14 and 20.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Breg, W. R., Miller, O. J., Miller, D. A., Allderdice, P. W.: Distinctive fluorescence of quinacrine-labeled human G-group chromosomes. Nature (Lond.) 231, 216–217 (1971).

    Google Scholar 

  • Caspersson, T., Zech, L., Johansson, C., Modest, E. J.: Identification of human chromosomes by DNA-binding fluorescent agents. Chromosoma (Berl.) 30, 215–227 (1970).

    Google Scholar 

  • de Capoa, A., Allen, F. H., Jr., Gold, A., Koenigsberger, R., Miller, O. J.: Presumptive C/15 translocation and familial large Y identified by autoradiography. J. med. Genet. 6, 89–94 (1968).

    Google Scholar 

  • Fredga, K., Hall, B.: A complex familial translocation involving chromosomes 5, 9 and 13. Cytogenetics 9, 294–306 (1970).

    Google Scholar 

  • Miller, J. R., Dill, F. J., Corey, M. J., Rigg, J. M.: A rare translocation (47,XY,t(2p-;21q+), 21+) associated with Down's syndrome. J. med. Genet. 7, 389–393 (1970).

    Google Scholar 

  • Nuzzo, F., Marini, A., Baglioni, C., Ford, C. E., DeCarli, L., Serini, L. P.: A case of multiple chromosomal rearrangements with persistence of fetal hemoglobin. Cytogenetics 7, 169–182 (1968).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human Genetics and Development, and Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York

    P. W. Allderdice, O. J. Miller & D. A. Miller

  2. Southbury Training School and Department of Pediatrics, Yale University, New Haven

    W. R. Breg

  3. Department of Pathology and Pediatrics, New York Medical College, Metropolitan Hospital Center, New York

    E. Gendel & C. Zelson

Authors
  1. P. W. Allderdice
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. J. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. A. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. R. Breg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Gendel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Zelson
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported in part by Research Grants GM 18 153, HD 00339 and Training Grnat 5T01 HD 00 118 from the National Institutes of Health. OJM is a Career Scientist of the Health Research Council of the City of New York.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Allderdice, P.W., Miller, O.J., Miller, D.A. et al. Familial translocation involving chromosome 6, 14 and 20, identified by quinacrine fluorescence. Humangenetik 13, 205–209 (1971). https://doi.org/10.1007/BF00326943

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00326943

Keywords

Search

Navigation