Summary
Base substitutions have been compared in two mitochondrial and two nuclear genes from three yeasts and three mammals. In yeasts, the two mitochondrial genes, cytochrome oxidase subunit 2 (COX2) and apocytochrome b (CYB), have fewer changes on a percentage basis than the nuclear-encoded cytochrome c (CYC) gene. By contrast, in mammals, the same mitochondrial genes have more mutations than CYC on a percentage basis. Sequence comparisons of the nuclear small-subunit ribosomal RNA (nSSU) gene shows that there are more substitutions per unit length in the three yeasts than in the three mammals. This result suggests that although the yeasts are more distantly related than the mammals, their mitochondrial genes have accumulated fewer changes.
Similar content being viewed by others
References
Anderson S, Bankier AT, Barell BG, De Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981) Nature 290:457–464
Bibb MJ, Van Etten RA, Wright CT, Walberg MW, Clayton D (1981) Cell 26:167–180
Brown WM, George M Jr, Wilson AC (1979) Proc Natl Acad Sci USA 76:1967–1971
Brown WM, Prager EM, Wang A, Wilson AC (1982) J Mol Evol 18:225–239
Brunner A, Coria R (1989) Yeast 5:209–218
Cann RL Brown WM, Wilson AC (1984) Genetics 106:479–499
Capaldi RA, Malastesta F, Darley-Usmar VM (1983) Biochim Biophys Acta 726:135–148
Cedergren R, Gray MW, Abel Y, Sankoff D (1988) J Mol Evol 28:98–112
Clark-Walker GD (1989) Proc Natl Acad Sci USA 86:8847–8851
Clark-Walker GD, McArthur CR, Sriprakash KS (1985) EMBO J 4:465–473
Coruzzi G, Tzagoloff A (1979) J Biol Chem 254:9324–9330
Dams E, Hendriks L, Van de Peer Y, Neefs J-M, Smits G, Vandenbempt I, De Wachter R (1988) Nucleic Acids REs 16:r87-r172
Evans MJ, Scarpulla RC (1988) Proc Natl Acad Sci USA 85:9625–9629
Fournier A, Fleer R, Yeh P, Mayaux J-F (1990) Nucleic Acids Res 18:365
Gadaleta G, Pepe G, DeCandia G, Quagliariello C, Sbisa E, Saccone C (1989) J Mol Evol 28:497–516
Gray MW (1989) Annu Rev Cell Biol 5:25–50
Hall J, Moubarak A, O'Brien P, Pan LP, Cho I, Millet F (1988) J Biol Chem 263:8142–8149
Hampsey DM, Das G, Sherman F (1986) J Biol Chem 261:3259–3271
Hardy CM, Clark-Walker GD (1990) Yeast 6:403–410
Hardy CM, Galeotti CL, Clark-Walker GD (1989) Curr Genet 16:419–427
Kadenbach B, Kuhn-Nentwig L, Guge U (1987) Curr Topics Bioenerg 15:113–161
Limbach KJ, Wu R (1985) Nucleic Acids Res 13:617–630
Maleszka R, Clark-Walker GD (1990) Nucleic Acids Res 18:1889
Miyata T, Hayashida H, Kikuno R, Hasegawa M, Kobayshi M, Koike K (1982) J Mol Evol 19:28–35
Montgomery DL, Leung DW, Smith M, Shalit P, Faye G, Hall BD (1980) Proc Natl Acad Sci USA 77:541–545
Morin GB, Cech TR (1988) Nucleic Acids Res 16:327–346
Nobrega FG, Tzagoloff A (1980) J Biol Chem 255:9828–9837
Palmer JD, Herbon LA (1988) J Mol Evol 28:87–97
Ragnini A, Fukuhara H (1988) Nucleic Acids Res 17:8433–8442
Rubtsov PM, Musakhanov MM, Zakharyev VM, Krayev AS, Skryabin KG, Bayev AA (1980) Nucleic Acids Res 8:5779–5794
Saliola M, Shuster JR, Falcone C (1990) Yeast 6:193–204
Scarpulla RC, Agne GM, Wu R (1981) J Biol Chem 256:6480–6486
Shuster J, Moyer D, Irvine B (1987) Nucleic Acids Res 15:8573
Smith M, Leung DW, Gillam S, Astell CR, Montgomery DL, Hall BD (1979) Cell 16:753–761
Stark MJR, Milner JS (1989) Yeast 5:35–50
Stiles JI, Friedman LR, Helms SC, Consaul S, Sherman F (1981) Mol Biol 148:331–346
Tzagoloff A, Myers AM (1986) Annu Rev Biochem 55:249–285
Wallace DC, Ye J, Neckelmann SN, Singh G, Webster KA, Greenberg BD (1987) Curr Genet 12:81–90
Wolf K (1987) In: Kinghorn JR (ed) Gene structure in eukaryotic microbes. SGM special publication 22. IRL Press, Oxford, pp 41–62
Wolfe KH, Li WH, Sharp PM (1987) Proc Natl Acad Sci USA 84:9054–9058
Wong OC, Clark-Walker GD (1990) Nucleic Acids Res 18:1888
Author information
Authors and Affiliations
Additional information
Communicated by R. J. Schweyen
Rights and permissions
About this article
Cite this article
Clark-Walker, G.D. Contrasting mutation rates in mitochondrial and nuclear genes of yeasts versus mammals. Curr Genet 20, 195–198 (1991). https://doi.org/10.1007/BF00326232
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00326232