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Enantiomeric separation of 5-Fluoro- and 6-Fluoro-d/l-dopa (3,4-dihydroxyphenylalanine)

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Summary

To study the metabolism of 5-Fluoro- and 6-Fluoro-l- and -d-dopa in organotypic brain cell cultures, the enantiomers of 5-Fluoro- and 6-Fluoro-d/l-dopa were separated. Commercial chiral columns CHIRALPAK WH showed excellent separation results for this system. The separation remained constant for more than 60 consecutive runs which implies the use of this column also for preparative purposes.

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Author notes

  1. Thomas Mäder

    Present address: Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland

  2. Claudia Wiese

    Present address: Laboratory of Viral and Molecular Pathogenesis, NINDS, National Institutes of Health, 20892, Bethesda, MD, USA

Authors and Affiliations

  1. Institute of Medical Radiobiology, c/o Paul Scherrer Institute, CH-5232, Villigen PSI, Switzerland

    Thomas Mäder, Mario Argentini, Claudia Wiese & Regin Weinreich

Authors
  1. Thomas Mäder
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  2. Mario Argentini
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  3. Claudia Wiese
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  4. Regin Weinreich
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Mäder, T., Argentini, M., Wiese, C. et al. Enantiomeric separation of 5-Fluoro- and 6-Fluoro-d/l-dopa (3,4-dihydroxyphenylalanine). Fresenius J Anal Chem 343, 324–325 (1992). https://doi.org/10.1007/BF00322383

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  • DOI: https://doi.org/10.1007/BF00322383

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