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TLC-screening of important pharmaceutical substances using fluorescence detection

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  • Pharmaceutical Analysis
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Summary

Observation of fluorescence reactions on TLC plates is a valuable additional tool within the scope of screening procedures for many toxicologically relevant substances commonly encountered in clinical- and forensic-toxicological analysis. The reactions are based on native fluorescence without any treatment and on reactions obtained with an approved derivatization procedure. Due to the enormous sensitivity of the fluorescence detection, the method is also applicable to very low concentrations and small amounts of biological materials. The procedures described in this article have proven their high pragmatic usefulness in many practical cases.

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Authors and Affiliations

  1. Institute for Legal Medicine, University of Giessen, Frankfurter Strasse 58, W-6300, Giessen, Germany

    G. Rochholz, A. Mayr & H. Schütz

Authors
  1. G. Rochholz
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  2. A. Mayr
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  3. H. Schütz
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Dedicated to Professor Dr. Wilhelm Fresenius on the occasion of his 80th birthday

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Rochholz, G., Mayr, A. & Schütz, H. TLC-screening of important pharmaceutical substances using fluorescence detection. Fresenius J Anal Chem 346, 819–827 (1993). https://doi.org/10.1007/BF00321297

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  • DOI: https://doi.org/10.1007/BF00321297

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