Summary
Six patients with Philadelphia-chromosome (Ph' +)-positive chronic granulocytic leukemia were transplanted from their HLA-identical siblings after conditioning with cyclophosphamide and 1'000 rad total body irradiation. All received cyclosporin-A for prophylaxis of Graft-versus-Host disease. All patients showed prompt engraftment and all are cytogenetically and clinically in complete remission. Two patients had transient mild signs of Graft-versus-Host-disease and one patient had unilateral facial nerve paresis of unknown origin. All are ambulatory and well 6–18 months (median 10 months) after transplantation.
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Supported by Grants of the Swiss Science Foundation 3.846.0.79, the Swiss Cancer League FOR.141.LR.79 (3) and the Swiss Public Health Service
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Speck, B., Gratwohl, A., Nissen, C. et al. Allogeneic marrow transplantation for chronic granulocytic leukemia. Blut 45, 237–242 (1982). https://doi.org/10.1007/BF00320190
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DOI: https://doi.org/10.1007/BF00320190