Summary
The frequency and degree of stiatopallidonigral (SPN) degeneration were examined in 41 autopsy cases of Pick's disease. Based on the degree of SPN degeneration, these cases were arranged into four groups: 1) group I (severely degenerate; 19.5%), 2) group II (moderately degenerate; 22.0%), 3) group III (mildly degenerate; 36.5%), and 4) group IV (non-degenerate; 22.0%). 17 of the 41 cases had a definite (moderate to severe) SPN degeneration. The striatum, especially the caudate nucleus, was most frequently and most severely affected, while the internal segment of the globus pallidus was least frequently and least severely affected. In general, the oral portions of the SPN nuclei were more severely involved. In addition, in the putamen and globus pallidus the dorsomedial portions adjacent to the internal capsule were apt to be affected more markedly than the other portions. In the substantia nigra the degeneration tended to be more predominant in the pars reticulata than in the pars compacta, although both were usually involved. In addition, the medial to central portions of the substantia nigra were more vulnerable. In comparing the severely and moderately degenerate groups (groups I and II) with the mildly and non degenerate groups (groups III and IV), the former had more female cases, longer duration of illness, and more third-stage cases. In addition, the former contained more cases with lower brain weight and (predominant) frontal atrophy type, and more atypical cases without Pick bodies, or with symmetrical pyramidal tract degeneration or with combined traumatic lesions. It is notable that in all cases with definite SPN degeneration no extrapyramidal involuntary movements had been detected.
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References
Akelaitis AJ (1944) Atrophy of basal ganglia in Pick's disease. A clinicopathological study. Arch Neurol Psychiatry 51:27–34
Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurol Sci 12:366–375
Bagh K von (1946) Klinische und pathologisch-anatomische Studien an 30 Fällen von umschriebener Atrophie der Grosshirnrinde (Picksche Krankheit). Ann Scand Sci Fenn [Med] 10:1–132
Becker E (1935) Klinische und anatomische Beiträge zur Pickschen Krankheit. Monatsschr Psychiatr 92:107–121
Bogaert L van (1934) Syndrome extrapyramidal au cours d'une maladie de Pick. J Belg Neurol Psychiatr 34:315–320
Braunmühl A von (1930) Picksche Krankheit. In: Bumke O (ed) Handbuch der Geisteskrankheiten XI. Spezieller Teil VII: Die Anatomie der Psychosen. Springer, Berlin, pp 673–715
Constantinidis J, Reinchard J, Tissot R (1974) Pick's disease. Histological and clinical correlations. Eur Neurol 11:208–217
Delay J, Brion S, Escourolle R (1961) Les lésions souscorticales dans la maladie de Pick. Rev Neurol (Paris) 104:338–342
Dewulf A (1935) Un cas de maladie de Pick avec lésions prédominantes dans les noyaux gris de la base du cerveau. J Belg Neurol Psychiatr 35:508–521
Fox CA, Rafols JA (1976) The striatal efferents in the globus pallidus and in the substantia nigra. In: Yahr MD (ed) The basal ganglia: association for research in nervous and mental disease, vol 55. Raven Press, New York, pp 37–55
Grünthal E (1927) Über die Picksche umschriebene Grosshirnatrophie. Klin Wochenschr 29 (cited from [6])
Hori A, Volles E, Witzke W, Spaar FW (1983) Pick's disease of early onset with neurologic symptomatology, rapid course, and nigral-striatal degeneration. Clin Neurol 2:8–15
Ishino H, Yokoyama S, Nakashima Y, Otsuki S, Morisada A (1971) Atrophy of basal ganglia in Pick's disease. Kyushu Neuropsychiatr (Fukuoka) 17:67–73
Jakob H (1960) Zur pathologischen Anatomie der Pickschen Krankheit. I. Mitteilung: Vergleichende Untersuchungen über Ausdehnung und Schwerpunkte der Atrophie. Arch Psychiatr Z Ges Neurol 201:269–297
Jansen J (1938) Über anatomische Veränderungen bei der Pickschen Krankheit. Acta Psychiatr Neurol 13:631–648
Kanazawa I, Kwak S, Sasaki H, Muramoto O, Mizutani T, Hori A, Nukina N (1988) Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction. J Neurol Sci 83:63–74
Kosaka K (1988) Clinical aspects of age-related dementia. Kongo Shuppan Tokyo
Kosaka K, Matsushita M, Oyanagi S, Hato K, Mehraein P (1980) Pick's disease with concomitant traumatic brain damages — five autopsied cases and a clinical review of the literature. Psychiatr Neurol Jpn 82:33–47
Kosaka K, Matsushita M, Mehraein P (1982) A clinicopathological study of Pick's disease — our sixty autopsied cases. Psychiatr Neurol Jpn 84:101–113
Kosaka K, Matsushita M, Iizuka R, Mehraein P (1982) Pick's disease and head trauma. Folia Psychiatr Neurol Jpn 36:125–136
Kosaka K, Ikeda K, Kobayashi K, Hamamoto J, Matsushita M (1985) On pyramidal tract lesions in Pick's disease. Clin Psychiatry Jpn 27:1171–1178
Kufs H (1927) Beitrag zur Histopathologie der Pickschen umschriebenen Grosshirnrindenatrophie. Z Neurol 108:786–802
Löwenberg K (1936) Pick's disease. A clinicopathologic contribution. Arch Neurol Psychiatr 36:768–789
Löwenberg K, Boyd DA, Salon DD (1939) Occurrence of Pick's disease in early adult years. Arch Neurol Psychiatr 41:1004–1020
Lüers T, Spatz H (1957) Picksche Krankheit. In: Lubarsch O, Henke F, Roessle R (eds) Handbuch der speziellen pathologischen Anatomie und Histologie, vol XIII/IA. Springer, Berlin Göttingen Heidelberg, pp 614–715
Malamud N, Waggoner RW (1943) Genealogic and clinicopathologic study of Pick's disease. Arch Neurol Psychiatry 50:288–303
Mansvelt J van (1954) Pick's disease. Dissertation, Utrecht
Munoz-Garcia D, Ludwin SK (1984) Classic and generalized variants of Pick's disease: a clinicopathological, ultrastructural, and immunocytochemical comparative study. Ann Neurol 16:467–480
Nauta WJH, Domesick VB (1984) Afferent and efferent relationships of the basal ganglia. Ciba Found Symp 107:3–29
Schenk VWD (1939) Lobair-atrophie van Pick. J Belg Neurol Psychiatr 39:581–590 (cited from [28])
Seitelberger F, Gross H, Pilz P (1983) Pick's disease: a neuropathological study. In: Hirano A, Miyoshi K (eds) Neuropsychiatric disorders in the elderly. Igaku-Shoin, Tokyo New York, pp 87–117
Simma K (1952) Die subcorticalen Veränderungen bei Pickscher Krankheit im Vergleich zur Chorea Huntington. Monatsschr Psychiatr Neurol 123:205–238
Spatz H (1927) Über Picksche Krankheit. Zentralbl Neurol 47:H 15 (cited from [7])
Suzuki S, Tanaka K, Tsunoda T, Sakuma H (1984) A case of Pick's disease associated with marked degeneration of the basal ganglia. Psychiatr Neurol Jpn 86:631–645
Uchihara T, Tsuchiya K, Kosaka K (1990) Selective loss of nigral neurons in Pick's disease. A morphometric study. Acta Neuropathol (Berl) 81:155–161
Urechia CI, Dragomir L, Elekes N (1935) Deux cas de la maladie de Pick. Un cas de la maladie d'Alzheimer. Existe-t-il des rapports etre ces maladies? Arch Int Neurol 54:55–83
Winkelmann NW, Boor MH (1949) Asymptomatic extrapyramidal involvement in Pick's disease. A clinicopathological study of two cases. J Neuropathol Exp Neurol 8:30–42
Yano K, Nishimura Y, Kumano S (1960) Ein Beitrag zur Histologie der Pickschen Krankheit mit besonderer Berücksichtigung der gliösen Elemente. Folia Psychiatr Neurol Jpn 14:123–139
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Kosaka, K., Ikeda, K., Kobayashi, K. et al. Striatopallidonigral degeneration in Pick's disease: a clinicopathological study of 41 cases. J Neurol 238, 151–160 (1991). https://doi.org/10.1007/BF00319682
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DOI: https://doi.org/10.1007/BF00319682