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The fine structure of human digital arterio-venous anastomoses (Hoyer-Grosser's organs)

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Summary

Hoyer-Grosser's organs were studied in human digital biopsies. The fine structure of both the supplying arteries and collecting veins was found to be inconspicuous.

Endothelial cells in the AV canals form a continuous layer. They are characterized by their rich content of specific organelles (Weibel-Palade bodies), especially in the venous segments. The epitheloid zone is composed of a variety of ramified smooth muscle cells (RSM). These appear either dense, when well provided with bundles of myofilaments, or clear, when including only a few myofilaments. The nuclei of dense RSM show condensed chromatin, while those of clear RSM are larger with loose chromatin texture. In addition, all transitional forms occur. Cell organelles are rarely seen within all types of RSM. The cytoplasmic processes reach each other as well as endothelial cells. The preservation of our material did not allow observation of specialized membrane contacts in these zones. All RSM are invested with a regular basal lamina and well provided with surface vesicles. Profiles of free basal lamina material and faint collagen (argyrophil) fibers are seen in the wide intercellular spaces.

RSM poor in myofilaments are interpreted to represent “epitheloid cells” of light microscopy. Their number constantly decreases from the arterial segment of the AV canal to the venous segment. Here the cytoplasmic processes of RSM become less pronounced and the wall of the anastomotic segment continuously changes to that of the collecting vein. Dense RSM rich in myofilaments are compared with pacemaker cells found in the ureter. Both internal and external elastic membranes are absent in AV canals.

A dense network of unmyelinated nerve fibers is found in the adventitial layer of the AV canal, especially in its arterial segment. The axons branch out from small dermal nerves which also contain two or three myelinated axons. The myelin sheaths terminate where the axons reach the adventitia of the AV canals. Axon varicosities filled with mitochondria are thought to be terminals of myelinated axons and are interpreted as receptory. Axon varicosities with synaptic-type vesicles are assumed to be terminals of sympathetic and parasympathetic fibers. All axon profiles are confined to the adventitial layer of the anastomotic segment.

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References

  • Blackwinkel, K.-P., Themann, H., Schmitt, G., Hauss, W.H.: Electron microscopic study on permeability of coronary artery wall of normotensive rabbits using horseradish peroxidase as a tracer. Beitr. Path. 156, 376–386 (1975)

    Google Scholar 

  • Barbolini, G., Tischendorf, F., Curri, S.B.: Histology, histochemistry and function of the human digital arterio-venous anastomoses (Hoyer-Grosser's organs, Masson's glomera) III. Pacinian corpuscles regressive changes related to senile involution and severe wasting of the arterio-venous anastomoses. Bioch. exp. Biol. 10, 345–350 (1972–1973)

    Google Scholar 

  • Bertini, F., Santolaya, R.C.: quoted from Santolaya and Bertini, 1970

  • Böck, P., Gorgas, K.: Fine structure of baroreceptor terminals in the carotid sinus of guinea pigs and mice. Cell Tiss. Res. 170, 95–112 (1976)

    Google Scholar 

  • Brown, M.E.: The occurrence of arterio-venous anastomoses in the tongue of the dog. Anat. Rec. 69, 287–297 (1937)

    Google Scholar 

  • Bucciante, L.: Anastomosi arterovenose e dispositivi regolatori del flusso sanguigno. Atti Soc. Int. Anat., X. Congr. Torino, in: Monit. Zool. Ital. 57, Suppl. 3 (1949)

  • Buchberger, R., Chinarelli, A., Curri, S.B., Magaro, M., Manzoli, U., Martines, G., Musacci, G.F., Pellegatti, P., Sensi, S.: Angiopatie periferiche e anastomosi arterovenose. Bioch. Biol. sper. 3, Suppl. (1964)

  • Burnstock, G.: Purinergic nerves. Pharmacol. Rev. 24, 509–581 (1972)

    Google Scholar 

  • Burnstock, G.: Comparative studies of purinergic nerves. J. Exp. Zool. 194, 103–134 (1975a)

    Google Scholar 

  • Burnstock, G.: Innervation of vascular smooth muscle: histochemistry and electron microscopy. Clin. exptl Pharmacol. Physiol., Suppl 2, 7–20 (1975b)

    Google Scholar 

  • Clara, M.: Arterio-venöse Nebenschlüsse. Verh. dtsch. Ges. Kreisl.-Forsch. 11, 226–255 (1938)

    Google Scholar 

  • Clara, M.: Die arterio-venösen Anastomosen. J.A. Barth, Leipzig: 1939, 1st Ed.

    Google Scholar 

  • Clara, M.: Die arterio-venösen Anastomosen 2nd Ed. Wien: Springer Verlag, 1956

    Google Scholar 

  • Clark, E.R.: Arterio-venous anastomoses. Physiol. Rev. 18, 229–247 (1938)

    Google Scholar 

  • Clark, E.R., Clark, E.L.: Observations on living arteriovenous anastomoses as seen in transparent chambers introduced into the rabbit's ear. Am. J. Anat. 54, 229–286 (1934)

    Google Scholar 

  • Clementi, F., Palade, G.E.: Intestinal capillaries. I. Permeability to peroxidase and ferritin. J. Cell Biol. 41, 33–58 (1969)

    Google Scholar 

  • Curri, S.B.: Istochimica dei mucopolisaccharidi. Riv. Anat. Pat. Oncol. 16, 900–938 (1959)

    Google Scholar 

  • Curri, S.B.: Angiopatie periferiche e anastomosi arterovenose. Liviana Ed., Padova: 1964

    Google Scholar 

  • Curri, S.B.: Fisiopatologia del circolo preterminale delle dita. Padova: Piccin Ed., 1968

    Google Scholar 

  • Curri, S.B., Manzoli, U., Tischendorf, F.: Die Fingerbeerenbiopsie. Klin. Wschr. 44, 584–590 (1966)

    Google Scholar 

  • Curri, S.B., Tischendorf, F.: Angiopatie periferiche e anastomosi arterovenose. Settim. Med. 53, 241–264 (1965)

    Google Scholar 

  • Curri, S.B., Tischendorf, F.: The senile involution of arteriovenous Anastomoses. Xth International Congress of Angiology, Tokyo, 30 Aug.–3 Sept. 1976 (in press)

  • Curri, S.B., Tischendorf, F., Lo Brutto, M.E.: Osservazioni sull'architettonica degli organi glomici del polpastrello delle dita (anastomosi arterovenose dell II Tipo Gruppo B): Distinzione tra connettivo intra- ed extraglomico e comportamento del mesenchima dermico in condizioni patologiche. Riv. Pat. clin. sper. 8, 559–584 (1967)

    Google Scholar 

  • Daniel, P.M., Prichard, M.L.: Arterio-venous anastomoses in the external ear. Quart. J. exp. Physiol. 41, 107–123 (1956)

    Google Scholar 

  • Devine, C.E., Somlyo, A.V., Somlyo, A.P.: Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles. J. Cell Biol. 52, 690–718 (1972)

    Google Scholar 

  • Dixon, J.S., Gosling, J.A.: The fine structure of pacemaker cells in the pig renal calices. Anat. Rec. 175, 139–154 (1973)

    Google Scholar 

  • Feyrter, F.: Über die vasculäre Neurofibromatose, nach Untersuchungen am menschlichen Magen-Darm-Schlauch. Virchows Arch. path. Anat. 317, 221–265 (1949)

    Google Scholar 

  • Flöel, H., Hammersen, F., Staubesand, J.: Weitere elektronenmikroskopische Untersuchungen an den epitheloiden Gefäßwandzellen. Beobachtungen an Glomustumoren. Anat. Anz., Suppl. 121, 295–300 (1968)

    Google Scholar 

  • Fuchs, A., Weibel, E.R.: Morphometrische Untersuchung der Verteilung einer spezifischen cytoplasmatischen Organelle in Endothelzellen der Ratte. Z. Zellforsch. 73, 1–9 (1966)

    Google Scholar 

  • Gabella, G.: The structure of smooth muscles of the eye and the intestine. In: Physiology of smooth muscle. E. Bülbring and M.F. Shuba eds., pp. 265–277. New York: Raven Press, 1976

    Google Scholar 

  • Golenhofen, K.: Physiologie der Kurzschlußdurchblutung. In: Die arteriovenösen Anastomosen. Anatomie, Physiologie, Pathologie, Klinik. F. Hammersen and D. Gross eds., pp. 67–81. Bern und Stuttgart: Verlag Hans Huber, 1968

    Google Scholar 

  • Gorgas, K., Böck, P.: Studies on intra-arterial cushions II. Distribution of horseradish peroxidase in cushions at the origins of intercostal arteries in mice. Anat. Embryol. 149, 315–321 (1976)

    Google Scholar 

  • Goodman, Th.F.: Fine structure of the cells of the Suquet-Hoyer canals. J. Invest. Dermatol. 59, 363–369 (1972)

    Google Scholar 

  • Goodman, Th.F., Abele, D.C.: Multiple glomus tumors. A clinical and electron microscopic study. Arch. Dermatol. 103, 11–23 (1971)

    Google Scholar 

  • Grosser, O.: Über arterio-venöse Anastomosen an den Extremitätenenden beim Menschen und den krallentragenden Säugetieren. Arch. mikr. Anat. 60, 191–216 (1902)

    Google Scholar 

  • Hammersen, F.: Zur Ultrastruktur der arteriovenösen Anastomosen. In: Die arterio-venösen Anastomosen. Anatomie, Physiologie, Pathologie, Klinik. F. Hammersen and D. Gross eds., pp. 24–37. Bern und Stuttgart: Verlag Hans Huber, 1968

    Google Scholar 

  • Hammersen, F.: The fine structure of epitheloid vascular cells. A comparative electron microscopic study. 6th Europ. Conf. Microcirculation, Aalborg 1970. pp. 406–410. Basel: Karger, 1971

    Google Scholar 

  • Hammersen, F.: Zur Orthologie des Wandbaues und der Histophysiologie terminaler Gefäße. Wege und Barrieren des transkapillaren Stoffaustausches. In: Angiologie. G. Heberer, G. Rau and W. Schoop eds., pp. 615–637, 2nd Ed. Stuttgart: Thieme, 1974

    Google Scholar 

  • Hammersen, F., Staubesand, J.: Licht- und elektronenmikroskopische Studien an den sogenannten epitheloiden Gefäßwandzellen. Anat. Anz., Suppl. 120, 251–257 (1967)

    Google Scholar 

  • Havliček, H.: Die Leistungszweiteilung des Kreislaufes in Vasa privata und Vasa publica. Verh. dtsch. Ges. Kreisl. forsch. 8, 237–245 (1935)

    Google Scholar 

  • Henningsen, B.: Zur Innervation arteriovenöser Anastomosen. Z. Zellforsch. 99, 139–145 (1969)

    Google Scholar 

  • Hett, J.: Zur feineren Innervation der arterio-venösen Anastomosen der Fingerbeere des Menschen. Z. Zellforsch. 33, 151–156 (1943)

    Google Scholar 

  • Hurley, H.J., Mescon, H.: Cholinergic innervation of the digital arterio-venous anastomoses of human skin. A histochemical localization of cholinesterase. J. appl. Physiol. 9, 82–87 (1956)

    Google Scholar 

  • Iijima, T., Tagawa, T.: Adrenergic and cholinergic innervation of the arteriovenous anastomosis in the rabbit's ear. Anat. Rec. 185, 373–380 (1976)

    Google Scholar 

  • Illig, L.: Die terminale Strombahn: Capillarbett und Mikrozirkulation. In: Pathologie und Klinik in Einzeldarstellungen, 10. Springer, Berlin-Göttingen-Heidelberg: 1961

    Google Scholar 

  • Knoche, H.: Untersuchungen über die feinere Innervation arteriovenöser Anastomosen. I. Z. Anat. Entwickl.-Gesch. 120, 379–391 (1958)

    Google Scholar 

  • Kondo, H.: An electron microscopic study on the caudal glomerulus of the rat. J. Anat. 113, 341–358 (1972)

    Google Scholar 

  • Lüders, G., Schlote, W., Reinhard, M.: Die sogenannten epitheloiden Zellen in Glomustumoren und arterio-venösen, epitheloidzelligen Knäuelanastomosen. Histogenese, Ultrastruktur und funktionelle Bedeutung. Med. Welt 22, 1374–1378 (1971)

    Google Scholar 

  • Majno, G.: Ultrastructure of the vascular membrane. In: Handbook of physiology, vol. 3, chap. 64, pp. 2293–2375. Washington DC: American Physiological Society, 1965

    Google Scholar 

  • Manzoli, U., Curri, S.B., Sensi, S., Martines, G., Buchberger, R.: Anastomosi arterovenose e angiopatie (correlazioni tra morfologica e funzione nel circolo derivativo digitale). Bioch. Biol. sper. 3, Suppl. (1964)

  • Martines, G., Tischendorf, F., Curri, S.B., Manzoli, U.: Die Ultrastruktur der epitheloiden Zellen (nach bioptischen Untersuchungen an normalen und pathologisch veränderten Hoyer-Grosserschen Organen des Menschen). Z. Anat. Entwickl.-Gesch. 124, 414–439 (1965a)

    Google Scholar 

  • Martines, G., Tischendorf, F., Curri, S.B., Manzoli, U., Musacci, G.: Electronenmikroskopische Untersuchungen an den epitheloiden Zellen der Hoyer-Grosserschen Organe. Naturwissensch. 52, 348 (1965b)

    Google Scholar 

  • Martines, G., Longhini, C., Musacchi, G.F.: L'ultrastruttura delle anastomosi artero-venose cutanee (Ricerche bioptiche digitali in soggetti normali). Arch. Ital Anat. Istol. Patol. 42, 131–147 (1968)

    Google Scholar 

  • Masson, P.: Les glomus neuro-vasculaires. Hermann et Cie, Paris: 1937

    Google Scholar 

  • Mescon, H., Hurles, H.J., Moretti, G.: The anatomy and histochemistry of the arteriovenous anastomosis in human digital skin. J. Invest. Dermatol. 27, 133–145 (1956)

    Google Scholar 

  • Molyneux, G.S.: The fine structure of dermal arteriovenous anastomoses in the sheep. J. Anat. 99, 951 (1965a)

    Google Scholar 

  • Molyneux, G.S.: The nature of the intercellular material between vascular epitheloid cells. J. Anat. 99, 951 (1965b)

    Google Scholar 

  • Molyneux, G.S.: Innervation of arteriovenous anastomoses. J. Anat. 106, 203 (1970)

    Google Scholar 

  • Nebert, H.: Histochemische Untersuchungen an den epitheloidzelligen Gefäßstrecken der Glomerula caudalia. II. Mitteilung: Mucopolysaccharide. Z. Zellforsch. 64, 611–635 (1964)

    Google Scholar 

  • Nonidez, J.F.: Arterio-venous anastomoses in the sympathetic chain ganglia of the dog. Anat. Rec. 82, 593–607 (1942)

    Google Scholar 

  • Popoff, V.W.: The digital vascular system. Arch. Pathol. 18, 295–330 (1934)

    Google Scholar 

  • Rhodin, J.A.G.: The ultrastructure of mammalian arterioles and precapillary sphincters. J. Ultrastruct. Res. 18, 181–223 (1967)

    Google Scholar 

  • Rotter, W.: Zur Pathologie der arterio-venösen Anastomosen. In: Die arterio-venösen Anastomosen. Anatomie, Physiologie, Pathologie, Klinik. F. Hammersen and D. Gross eds., pp. 46–57, Bern und Stuttgart: Verlag Hans Huber, 1968

    Google Scholar 

  • Santolaya, R.C., Bertini, F.: Fine structure of endothelial cells of vertebrates. Distribution of dense granules. Z. Anat. Entwickl.—Gesch. 131, 148–155 (1970)

    Google Scholar 

  • Schorn, J.: Zur Orthologie und Pathologie der Hoyer-Grosserschen Organe — sogenannter arterio-venösen Anastomosen—in den Endgliedern menschlicher Extremitäten. Stuttgart: Thieme, 1959

    Google Scholar 

  • Schumacher, S. von: Über das Glomus coccygeum des Menschen und die Glomeruli caudales der Säugetiere. Arch. mikr. Anat. 71, 58–115 (1907)

    Google Scholar 

  • Schumacher, S. von: Über die Bedeutung der arteriovenösen Anastomosen und der epitheloiden Muskelzellen (Quellzellen). Z. mikrosk.-anat. Forsch. 43, 107–130 (1938)

    Google Scholar 

  • Sherman, J.L.: Normal arteriovenous anastomoses. Medicine (Baltimore) 42, 247–267 (1963)

    Google Scholar 

  • Spanner, R.: Anatomie der arterio-venösen Anastomosen. Verh. dtsch. Ges. Kreisl. forsch. 18, 257–277 (1952)

    Google Scholar 

  • Staubesand, J.: Zur Anatomie menschlicher Glomusorgane. Verh. Anat. Ges. 49, 174–181 (1951)

    Google Scholar 

  • Staubesand, J.: Normale Anatomie, arteriovenöse Anastomosen. In: Angiologie. G. Heberer, G. Rau and W. Schoop eds., pp. 30–39, 2nd Ed. Stuttgart: Thieme, 1974

    Google Scholar 

  • Tischedorf, F.: Experimentelle Untersuchungen zur Histo-Biologie der arterio-venösen Anastomosen. Z. mikrosk.-anat. Forsch. 43, 153–178 (1938)

    Google Scholar 

  • Tischendorf, F.: Bau und Funktion der arterio-venösen Anastomosen. Dtsch. Med. Rdschau 2, Heft Nr. 11 (1948)

  • Tischendorf, F.: Morphobiologie der arterio-venösen Anastomosen. Bioch. Biol. Sper. 9, 241–254 (1970–1971)

    Google Scholar 

  • Tischendorf, F., Curri, S. B.: Le anastomosi arterovenose e i dispositivi di blocco nella morfologia normale e patologica. Riv. Anat. Patol. 8, 285–376 (1954)

    Google Scholar 

  • Tischendorf, F., Curri, S.B.: Experimentelle Untersuchungen zur Histophysiologie und-Pathologie der arterio-venösen Anastomosen (nach Lebendbeobachtungen am Kaninchenohr). III. Mitteilung: Morphologische und mikrooszillographische Analyse des Öffnungs- und Schließungsmechanismus. Z. mikrosk.-anat. Forsch. 62, 326–347 (1956)

    Google Scholar 

  • Tischendorf, F., Curri, S.B.: Bioptische Untersuchungen normaler und pathologisch (Morbus Winiwarter-Bürger und Morbus Raynaud) veränderter Hoyer-Grosserscher Organe des Menschen mit besonderer Berücksichtigung der epitheloiden Zellen. Acta anat. 53, 193–216 (1963)

    Google Scholar 

  • Tischendorf, F., Curri, S.B.: The senile involution of arteriovenous anastomoses (after bioptic and autoptic examination of the human finger-tip). Bioch. exper. Biol. 11, 207–228 (1974–1975)

    Google Scholar 

  • Vogel, W., Vogel, V., Schlote, W.: Ultrastructural study of arterio-venous anastomoses in gill filaments of Tilapia mossambica. Cell Tiss. Res. 155, 491–512 (1974)

    Google Scholar 

  • Walder, D.N.: The function of the arterio-venous anastomoses in the human stomach. Angéologie 9, 21 (1957)

    Google Scholar 

  • Watzka, M.: Über Gefäßsperren, arterio-venöse Anastomosen und den Erythrocytenabbau im Rinderlymphknoten. Z. mikroskop.-anat. Forsch. 39, 250–262 (1936)

    Google Scholar 

  • Weibel, E.R., Palade, G.E.: New cytoplasmic components in arterial endothelia. J. Cell Biol. 23, 101–112 (1964)

    Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, University of Cologne, Cologne, FRG

    Karin Gorgas, Peter Böck, Friedrich Tischendorf & Sergio B. Currî

  2. Centro di Biologia Molecolare, Milano, Italy

    Karin Gorgas, Peter Böck, Friedrich Tischendorf & Sergio B. Currî

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  1. Karin Gorgas
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Gorgas, K., Böck, P., Tischendorf, F. et al. The fine structure of human digital arterio-venous anastomoses (Hoyer-Grosser's organs). Anat. Embryol. 150, 269–289 (1977). https://doi.org/10.1007/BF00318346

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