Skip to main content
SpringerLink
Log in

A quantitative approach to cytoarchitectonics

VII. The areal pattern of the cortex of the guinea pig

  • Published:
Anatomy and Embryology Aims and scope Submit manuscript

Summary

The cerebral cortex of the guinea pig has been examined by means of a quantitative cytoarchitectonic method (Schleicher et al. 1978; Zilles et al. 1978a). In this method, a computer-controlled automatic image analyzer determines the grey level index of microscopic fields measuring 50x50 μm in Nissl-stained sections by a systematic scanning procedure. Computer plots of serially sectioned histological slides from three hemispheres were produced by printing selected ranges of grey level indices. The delineation of cortical areas was worked out in these plots based on quantitative criteria. Cortical maps of the areal pattern were reconstructed graphically.

The resulting cortical map of the guinea pig differes from that of Rose (1912), but it corresponds to the results of Friede (1960) and is in agreement with neurophysiological studies. In general, the areal pattern of the guinea pig is similar to that of the rat (Zilles et al. 1980), but there are also some differences. These differences are discussed with respect to functional considerations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Brodmann K (1909) Vergleichende Lokalisationslehre der Großhirnrinde in ihren Prinzipien dargestellt auf Grund des Zellbaues. Barth Leipzig

    Google Scholar 

  • Campos GB, Welker WI (1976) Comparison between brains of a large and a small hystricomorph rodent: Capybara, Hydrochoerus and guinea pig, Cavia; neocortical projections and measurements of brain subdivisions. Brain Behav Evol 13:243–266

    Google Scholar 

  • Choudhury BP (1978) Retinotopic organization of the guinea pig's visual cortex. Brain Res 144:19–29

    Google Scholar 

  • Creel D, Giolli RA (1972) Retinogeniculostriate projection in guinea pigs: Albino and pigmented strains compared. Exp Neurol 36:411–425

    Google Scholar 

  • Donoghue IP, Kerman KL, Ebner FF (1979) Evidence for two organizational plans within the somatic sensory-motor cortex of the rat. J Comp Neurol 193:647–664

    Google Scholar 

  • Droogleever Fortuyn AB (1911) De cytoarchitectonie der groote hersenschors van eenige knaagdieren. Thesis, Amsterdam Scheltema en Holkema Amsterdam

  • Felgenhauer K (1963) Die Lokalisation der spezifischen und unspezifischen Phosphatasen im Meerschweinchengehirn. Z Zellforsch 60:518–531

    Google Scholar 

  • Felgenhauer K, Stammler A (1962) Das Verteilungsmuster der Dehydrogenasen und Diaphorasen im Zentralnervensystem des Meerschweinchens. Z Zellforsch 58:219–233

    Google Scholar 

  • Fleischhauer K, Zilles K, Schleicher A (1980) A revised cytoarchitectonic map of the neocortex of the rabbit (Oryctolagus cuniculus). Anat Embryol 161:121–143

    Google Scholar 

  • Friede RL (1960) Histochemical investigations on succinic dehydrogenase in the central nervous system. IV. A histochemical mapping of the cerebral cortex of the guinea pig. J Neurochem 5:156–171

    Google Scholar 

  • Geneser-Jensen FA (1971a) Distribution of monoamine oxidase in the hippocampal region of the guinea pig. I. Entorhinal area, parasubiculum, and presubiculum. Z Zellforsch 117:46–64

    Google Scholar 

  • Geneser-Jensen FA (1971b) Distribution of monoamine oxidase in the hippocampal region of the guinea pig. II. Subiculum and hippocampus. Z Zellforsch 121:327–340

    Google Scholar 

  • Geneser-Jensen FA (1972a) Distribution of acetyl cholinesterase in the hippocampal region of the guinea pig. II. Subiculum and hippocampus. Z Zellforsch 124:546–560

    Google Scholar 

  • Geneser-Jensen FA (1972b) Distribution of acetyl cholinesterase in the hippocampal region of the guinea pig. III. The dentate area. Z Zellforsch 131:481–495

    Google Scholar 

  • Geneser-Jensen FA (1973) Distribution of monoamine oxidase in the hippocampal region of the guinea pig. III. The dentate area. Z Zellforsch 137:1–12

    Google Scholar 

  • Geneser-Jensen FA, Blackstad TW (1971) Distribution of acetyl cholinesterase in the hippocampal region of the guinea pig. I. Entorhinal area, parasubiculum, and presubiculum. Z Zellforsch 114:460–481

    Google Scholar 

  • Geneser-Jensen FA, Haug FMS, Danscher G (1974) Distribution of heavy metals in the hippocampal region of the guinea pig. A light microscope study with Timm's sulfide silver method. Z Zellforsch 147:441–478

    Google Scholar 

  • Gerebtzoff MA (1940) Recherches sur l'écore cérébrale et le thalamus du cobaye. I. Étude architectonique. La Cellule 48:337–352

    Google Scholar 

  • Gerebtzoff MA, Wauters A (1941) Recherches sur l'écore cérébrale et le thalamus du cobaye. II. Systématisation cortico-thalamique et voies efférentes de l'écorce cérébrale. La Cellule 49:6–70

    Google Scholar 

  • Hall RD, Lindholm EP (1974) Organization of the motor and somatosensory neocortex in the albino rat. Brain Res 66:23–28

    Google Scholar 

  • Hellweg FC, Koch R, Vollrath M (1977) Representation of the cochlea in the neocortex of guinea pig. Exp Brain Res 29:467–474

    Google Scholar 

  • Johnson TN (1957) Studies on the brain of the guinea pig. I. The nuclear pattern of certain basal telencephalic centers. J Comp Neurol 107:353–377

    Google Scholar 

  • Jones EG, Porter R (1980) What is Area 3 a? Brain Res Rev 2:1–43

    Google Scholar 

  • Kayer D, Legouix JP (1963) Projections tonotopique sur le cortex auditif du cobaye. Compt Rend Soc Biol (Paris) 157:2161–2164

    Google Scholar 

  • Krettek JE, Price JL (1977) The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat. J Comp Neurol 171:157–192

    Google Scholar 

  • Lende RA, Woolsey CN (1956) Sensory and motor localization in cerebral cortex of porcupine (Erethizon dorsatum). J Neurophysiol 19:544–563

    Google Scholar 

  • Levinson DM, Riffle DW, Reeves DL, Sheridan CL (1977) Enhancement of discrimination learning following unilateral lesion of posterior neocortex in guinea pigs. Physiol Behav 19:513–517

    Google Scholar 

  • Lohmann AHM (1963) The anterior olfactory lobe of the guinea pig. Acta Anat 53 Suppl 49:1–109

    Google Scholar 

  • Merzenich MM, Brugge JF (1973) Representation of the cochlear partition on the superior temporal plane of the macaque monkey. Brain Res 50:275–296

    Google Scholar 

  • Pilleri G (1959) Beiträge zur vergleichenden Morphologie des Nagetiergehirnes. Acta Anat 39 Suppl 38:43–95

    Google Scholar 

  • Pilleri G (1960) Comparative anatomical investigations on the central nervous system of rodents, and relationships between brain from and taxonomy. Rev Suise Zool 67:373–386

    Google Scholar 

  • Romeis B (1968) Mikroskopische Technik. Oldenbourg München

    Google Scholar 

  • Rose M (1912) Histologische Lokalisation der Großhirnrinde bei kleinen Säugetieren (Rodentia, Insektivora, Chiroptera). J Psychol Neurol 19:391–479

    Google Scholar 

  • Schleicher A, Zilles K, Kretschmann HJ (1978) Automatische Registrierung und Auswertung eines Grauwertindex in histologischen Schnitten. Anat Anz (Erg-H) 144:413–415

    Google Scholar 

  • Shipley MT, Geneser-Jensen FA, Meier A (1974) Correlated histochemical and experimental evidence for a subdivision of the entorhinal area of the guinea pig. Cell Tissue Res 150:455–462

    Google Scholar 

  • Sørensen KE (1980) Ipsilateral projection from subiculum to the retrospleneal cortex in the guinea pig. J Comp Neurol 193:893–911

    Google Scholar 

  • Stephan H (1975) Allocortex. In: Bargmann W (ed) Handbuch der mikroskopischen Anatomie des Menschen. 4 Bd, Teil 9, Nervensystem. Springer Berlin-Heidelberg-New York

    Google Scholar 

  • Woolsey TA, Welker C, Schwartz RH (1976) Comparative anatomical studies of the Sm I face cortex with speical reference to the occurence of “barrels” in layer IV. J Comp Neurol 164:79–94

    Google Scholar 

  • Zeigler HP (1964) Cortical sensory and motor areas of the guinea pig (“Cavia parcellus”). Arch Ital Biol 102:587–598

    Google Scholar 

  • Zilles K, Schleicher A, Kretschmann HJ (1978a) A quantitative approach to cytoarchitectonics. I. The areal pattern of the cortex of Tupaia belangeri. Anat. Embryol 153:195–212

    Google Scholar 

  • Zilles K, Schleicher A, Kretschmann HJ (1978b) A quantitative approach to cytoarchitectonics. II. The allocortex of Tupaia belangeri. Anat Embryol 154:335–352

    Google Scholar 

  • Zilles K, Schleicher A, Kretschmann HJ (1978c) Quantitative Darstellung cytoarchitektonischer Areale im Cortex von Tupaia belangeri und SPF-Katze. Anat Anz (Erg-H) 144:409–411

    Google Scholar 

  • Zilles K, Schleicher A, Kretschmann HJ (1978d) Automatische Messung des Grauwertindex zur Charakterisierung zytoarchitektonischer Areale im Allo-und Neocortex. Zbl Allg Path 122:593

    Google Scholar 

  • Zilles K, Rehkämper G, Stephan H, Schleicher A (1979a) A quantitative approach to cytoarchitectonics. IV. The areal pattern of the cortex of Galago demidovii (E. Geoffroy, 1796), (Lorisidae, Primates). Anat Embryol 157:81–103

    Google Scholar 

  • Zilles K, Rehkämper G, Schleicher A (1976b) A quantitative approach to cytoarchitectonics. V. The areal pattern of the cortex of Microcebus murinus (E. Geoffroy, 1828), (Lemuridae, Primates). Anat Embryl 157:269–289

    Google Scholar 

  • Zilles K, Zilles B, Schleicher A (1980) A quantitative approach to cytoarchitectonics. VI. The areal pattern of the cortex of the albino rat. Anat Embryol 159:335–360

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anatomisches Institut der Universität Kiel, Bundesrepublik Deutschland

    Andreas Wree, Karl Zilles & Axel Schleicher

Authors
  1. Andreas Wree
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karl Zilles
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Axel Schleicher
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by Deutsche Forschungsgemeinschaft grants Zi 192/4-3

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wree, A., Zilles, K. & Schleicher, A. A quantitative approach to cytoarchitectonics. Anat Embryol 162, 81–103 (1981). https://doi.org/10.1007/BF00318096

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00318096

Key words

Search

Navigation