Summary
The crossed cerebello-olivary projection in the cat was studied by means of retrograde transport of HRP.
The cerebello-olivary connection is organized according to a zonal pattern similar to that of the olivocerebellar projection. However, some labelled neurons are in addition found in cerebellar nuclear areas adjacent to a nuclear zone sending its fibres to the corresponding olivary region. This observation indicates that there is a certain degree of overlapping between the different nuclear zones.
The cerebello-olivary fibres from the fastigial nucleus appear to be more widely distributed than those from the other cerebellar nuclei.
Nuclear neurons of all sizes project to the inferior olive, but the majority of the cells are medium sized.
The findings are discussed and related to previous studies on the cerebello-olivary connection.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Achenbach KE, Goodman DC (1968) Cerebellar projections to pons, medulla and spinal cord in the albino rat. Brain Behav Evol 1:43–57
Ban M, Ohno T (1977) Projection of cerebellar nuclear neurones to the inferior olive by descending collaterals of ascending fibres. Brain Res 133:156–161
Beitz AJ (1976) The topographical organization of the olivo-dentate and dentato-olivary pathways in the cat. Brain Res 115:311–317
Berkley KJ, Worden IG (1978) Projections to the inferior olive of the cat. I. Comparisons of input from the dorsal column nuclei, the lateral cervical nucleus, the spino-olivary pathways, the cerebral cortex and the cerebellum. J Comp Neurol 180:237–252
Brodal A (1940) Experimentelle Untersuchungen über die olivocerebellare Lokalisation. Z ges Neurol Psychiat 169:1–153
Brodal A, Courville J (1973) Cerebellar corticonuclear projection in the cat. Crus II. An experimental study with silver methods. Brain Res 50:1–23
Brodal A, Kawamura K (1980) The olivocerebellar projection: a review. Adv Anat Embryol Cell Biol 64:VII+140
Brown JT, Chan-Palay V, Palay SL (1977) A study of afferent input to the inferior olivary complex in the rat by retrograde axonal transport of horseradish peroxidase. J Comp Neurol 176:1–22
Buisseret-Delmas C, Batini C (1978) Topology of the pathways to the inferior olive: An HRP study in the cat. Neurosci Lett 10:207–214
Chan-Palay V (1977) Cerebellar dentate nucleus: Organization, cytology and transmitters. Springer Verlag Berlin-Heidelberg-New York
Courville J, Augustine JR, Martel P (1977) Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase. Brain Res 130:405–419
Dietrichs E (1981) The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase. III. The anterior lobe. Anat Embryol In press
Dietrichs E, Walberg F (1979) The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase. I. The paramedian lobule. Anat Embryol 158:13–39
Dietrichs E, Walberg F (1980) The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase. II. Lobulus simplex, crus I and II. Anat Embryol 161:83–103
Dom R, King JS, Martin GF (1973) Evidence for two direct cerebello-olivary connections. Brain Res 57:498–501
Flood S, Jansen J (1961) On the cerebellar nuclei in the cat. Acta Anat 46:52–72
Graybiel AM, Nauta HJW, Lasek RJ, Nauta WJH (1973) A cerebello-olivary pathway in the cat: an experimental study using autoradiographic tracing techniques. Brain Res 58:205–211
Groenewegen HJ, Voogd J (1977) The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of the cat cerebellum. J Comp Neurol 174:417–488
Groenewegen HJ, Voogd J, Freedman SL (1979) The parasagittal zonation within the olivocerebellar projection. II. Climbing fiber distribution in the intermediate and hemispheric parts of cat cerebellum. J Comp Neurol 183:551–602
Haines DE, Rubertone JA (1979) Cerebellar corticonuclear fibers of the dorsal culminate lobule (anterior lobe-lobule V) in a prosimian primate, Galago senegalensis. J Comp Neurol 186:321–342
Itaya SK, Williams TH, Engel EL (1978) Anterograde transport of horseradish peroxidase enhanced by poly-L-ornithine. Brain Res 150:170–176
Kalil K (1979) Projections of the cerebellar and dorsal column nuclei upon the inferior olive in the Rhesus monkey: An autoradiographic study. J Comp Neurol 188:43–62
King JS, Andrezik JA, Falls WM, Martin GF (1976) The synaptic organization of the cerebello-olivary circuit. Exp Brain Res 26:159–170
Korneliussen HK (1967) Cerebellar corticogenesis in Cetacea, with special reference to regional variations. J Hirnforsch 9:151–185
Korneliussen HK (1968) On the ontogenetic development of the cerebellum (nuclei, fissures, and cortex) of the rat, with special reference to regional variations in corticogenesis. J Hirnforsch 10:379–412
Lapresle J, Hamida MB (1970) The dentato-olivary pathway. Somatotopic relationship between the dentate nucleus and the contralateral inferior olive. Arch Neurol 22:135–143
Martin GF, Dom R, King JS, Robards M, Watson CRR (1975) The inferior olivary nucleus of the opossum (Didelphis marsupialis virginiana), its organization and connections. J Comp Neurol 160:507–534
Martin CF, Henkel CK, King JS (1976) Cerebello-olivary fibers: Their origin, course and distribution in the North American opossum. Exp Brain Res 24:219–236
McCrea RA, Bishop GA, Kitai ST (1978) Morphological and electrophysiological characteristics of projection neurons in the nucleus interpositus of the cat cerebellum. J Comp Neurol 181:397–420
Mesulam MM (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26:106–117
Mesulam MM, Rosene D (1979) Sensitivity in horseradish peroxidase neurohistochemistry: A comparative and quantitative study of nine methods. J Histochem Cytochem 27:763–773
Mizuno N, Konishi A, Itoh K, Iwahori N, Nakamura Y (1980) Identification of axon terminals of the cerebello-olivary fibers in the cat: An electron microscope study using the anterograde horseradish peroxidase method. Neurosci Lett 20:11–14
Oscarsson O (1979) Functional units of the cerebellum — sagittal zones and microzones. Trends Neurosci 2:143–145
Sugimoto T, Mizuno N, Nomura S, Nakamura Y (1980) Fastigio-olivary fibers in the cat as revealed by the autoradiographic tracing method. Brain Res 199:443–446
Tolbert DL, Massopust LC, Murphy MG, Young PA (1976) The anatomical organization of the cerebello-olivary projection in the cat. J Comp Neurol 170:525–544
Tolbert DL, Bantli H, Bloedel JR (1978) Multiple branching of cerebellar efferent projections in cats. Exp Brain Res 31:305–316
Voogd J (1964) The cerebellum of the cat. Structure and fibre connexions. Thesis. Van Gorcum Assen
Voogd J, Bigaré F (1980) Topographical distribution of olivary and corticonuclear fibers in the cerebellum: A review. In: Courville J, de Montigny C, Lamarre Y (eds) The inferior olivary nucleus: Anatomy and physiology. Raven Press New York
Walberg F, Pompeiano O, Westrum LE, Hauglie-Hanssen E (1962) Fastigioreticular fibers in the cat. An experimental study with silver methods. J Comp Neurol 119:187–199
Walberg F, Nordby T, Dietrichs E (1980) A note on the anterograde transport of horseradish peroxidase within the olivocerebellar fibres. Exp Brain Res 40:233–236
Author information
Authors and Affiliations
Additional information
Research Fellow, The Norwegian Research Council for Science and the Humanities
Rights and permissions
About this article
Cite this article
Dietrichs, E., Walberg, F. The cerebellar nucleo-olivary projection in the cat. Anat Embryol 162, 51–67 (1981). https://doi.org/10.1007/BF00318094
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00318094