Abstract
The effects of progressive ventricular dilation on the development of the somatosensory cortex (SmI) were studied in congenital hydrocephalic rats, with regard to early serotonergic innervation and formation of functional cellular columns. In hydrocephalic rats, the time course, immunoreactivity, and patterns of formation and synaptogenesis of serotonin immunoreactive (5-HT-IR) terminal aggregations, which characterize the development of the SmI, were preserved. After disappearance of 5-HT-IR terminals, characteristic barrel cytoarchitecture formed normally at the site where 5-HT-IR terminal aggregations had been present. With the progression of hydrocephalus, the cerebral cortex became extremely thin and its total surface area was greatly increased, while barrels were preserved and their areas did not enlarge. These findings suggest that the basic development and the fundamental cytoarchitecture of the cortex are resistant to adverse effects of hydrocephalus.
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References
Chovanes GI, McAllister JP II, Lamperti AA, Salotto AG, Truex RC (1989) Monoamine alterations during experimental hydrocephalus in neonatal rats. Neurosurgery 22:86–91
D'Amato R, Blue BL, Largent BL, Lynch DR, Ledbetter DJ, Molliver ME, Shnyder SH (1987) Ontogeny of the serotonergic projection of rat neocortex: transient expression of a dense innervation to primary sensory areas. Proc Natl Acad Sci 84: 4322–4336
Ehara K, Matsumoto S, Yoshida N, Kuno T, Tanaka C (1982) Ascending norepinephrine pathways impaired in experimental hydrocephalus. Jpn J Pharmacol 32:205–208
Felten DL, Hallman H, Jonsson G (1982) Evidence for a neurotrophic role of noradrenaline neurons in the postnatal development of rat cerebral cortex. J Neurocytol 11:119–135
Foote SL, Morrison JH (1988) Development of the noradrenergic, serotonergic, and dopaminergic innervation of neocortex. In: Segawa M (ed) Brainstem, midbrain, telencephalon and behavior. Sanposha Printing, Tokyo, pp 161–189
Fujimiya M, Kimura H, Maeda T (1986) Postnatal development of serotonin nerve fibers in the somatosensory cortex of mice studied by immunohistochemistry. J Comp Neurol 24:191–201
Fujimiya M, Kimura H, Maeda T (1988) Development of cerebral cortex and serotonin innervation. In: Segawa M (ed) Brainstem, midbrain, telencephalon and behavior. Sanposha Printing, Tokyo, pp 147–160
Koralek KA, Jensen KF, Killackey HP (1988) Evidence for two complementary patterns of thalamic input to the rat somatosensory cortex. Brain Res 463:346–351
Koyama T (1970) Erzeugung von Mißbildungen im Gehirn durch Methyl-nitroso-Harnstoff und Ethyl-nitroso-Harnstoff an SD-JCL-Ratten (in Japanese). Arch Jpn Chir 39:233–254
Lauder HGW, Bloom FE (1972) Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation. J Comp Neurol 155:469–482
Lovely TJ, McAllister JP II, Miller DW, Lamperti AA, Wolfson BJ (1989) Effects of hydrocephalus and surgical decompression on cortical norepinephrine levels in neonatal cats. Neurosurgery 24:43–52
Maeda T, Tohyama M, Shimizu N (1974) Modification of postnatal development of neocortex in the rat brain with experimental deprivation of locus coeruleus. Brain Res 70:515–520
McMahon D (1974) Chemical messenger in development: a hypothesis. Science 185:1012–1021
Molliver ME, Kristt DA (1975) The fine structural demonstration of monoaminergic synapses in immature rat neocortex. Neurosci Lett 1:305–310
Rhoades RW, Bennett-Clarke CA, Chiaia NL, White FA, Mac-Donald GJ, Haring JH, Jacquin MF (1990) Development and lesion induced reorganization of the cortical representation of the rat's body surface as revealed by immunohistochemistry for serotonin. J Comp Neurol 293:190–207
Rice FL, Gomez C, Barstow C, Burnet A, Sands P (1985) A comparative analysis of the development of the primary somatosensory cortex: interspecies similarities during barrel and laminar development. J Comp Neurol 236:477–495
Sato K, Wada M, Nakagata N, Ito M, Miyaoka M, Ishii S (1985) Congenital hydrocephalus in the albino rat (HTX). I. Clinicopathological study (in Japanese). (Annual Report of the Research Commitee of “Intractable Hydrocephalus”) Ministry of Health and Welfare of Japan, pp 5–12
Suzuki F, Fujimiya M, Kimura H, Handa J, Maeda T (1990) Serotonergic terminal aggregation in the somatosensory cortex of rat during early postnatal period (abstract). Acta Histochem 22:737
Takeuchi Y, Kimura H, Sano Y (1982) Immunohistochemical demonstration of the distribution of serotonin neurons in the brain stem of the rat and cat. Cell Tissue Res 224:247–267
Welker C (1971) Microelectrode delination of fine grain somatotopic organization of SmI cerebral neocortex in albino rat: description and comparison with the mouse. J Comp Neurol 166:173–190
Wendlandt S, Crow TJ, Stirling RV (1977) The involvement of the noradrenergic system arising from the locus coeruleus in the postnatal development of the cortex in rat brain. Brain Res 125:1–9
Woolsey TA, Van Der Loos H (1970) The structural organization of layer IV in the somatosensory (SI) region of mouse cerebral cortex. Brain Res 17:205–242
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Suzuki, F., Handa, J. & Maeda, T. Effects of congenital hydrocephalus on serotonergic input and barrel cytoarchitecture in the developing somatosensory cortex of rats. Child's Nerv Syst 8, 18–24 (1992). https://doi.org/10.1007/BF00316557
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DOI: https://doi.org/10.1007/BF00316557