Skip to main content
SpringerLink
Log in

Polyradicular neuritis and Hashimoto's thyroiditis

  • Published:
Journal of Neurology Aims and scope Submit manuscript

Summary

The case of a patient with a pluripotential immuneproliferative syndrome is reported. She suffered from Hashimoto's thyroiditis with secondary cold agglutination disease and from polyradicular neuritis. Polyradicular neuritis with albumino-cytological dissociation in the CSF had developed chronically and improved only when corticosteroid therapy was begun. Based on this case report fundamental considerations concerning the pathogenesis and therapy of Landry-Guillain-Barré-Strohl syndrome are discussed.

Zusammenfassung

Es wird über eine Patientin mit einem pluripotentiellen immunproliferativen Syndrom berichtet, die an einer Hashimoto-Thyreoiditis mit sekundärer Kälteagglutinationskrankheit und einer Polyradiculoneuritis litt. Die Polyradiculoneuritis mit albumino-cytologischer Dissoziation im Liquor hatte sich chronisch entwickelt und besserte sich erst mit dem Einsetzen einer Corticosteroidtherapie. An Hand dieses Fallberichtes werden grundsätzliche Erwägungen zur Pathogenese und Therapie des Landry-Guillain-Barré-Strohl-Syndromes diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Austin, J. H.: Recurrent polyneuropathies and their corticosteroid treatment. Brain 81, 157 (1958)

    Google Scholar 

  • Becker, K. L., Titus, J. L., McCohaney, W. M., Woolner, L. B.: Morphologic evidence of thyroiditis in myasthenia gravis. J. Amer. med. Ass. 187, 104 (1964)

    Google Scholar 

  • Becker, K. L., Titus, J. L., Woolner, L. B., McConahey, W. M.: Significance of morphologic thyroiditis. Ann. intern. Med. 62, 1134 (1965)

    Google Scholar 

  • Behan, P. O., Lamarche, J. B., Behan, W. M., Feldman, R. G.: Immunopathological mechanisms of allergic neuritis in animals, primates, and man. Trans. Amer. Neurol. Ass. 94, 219 (1969)

    Google Scholar 

  • Behan, P. O., Lamarche, J. B., Feldman, R. G., Sheremata, W. A.: Lymphocyte transformation in the Guillain-Barré syndrome. Lancet 1970 I, 421

    Google Scholar 

  • Bronsky, D., Meltzer, J. L., Waldstein, S. S.: Idiopathic juvenile myxedema and myasthenia gravis. A case with circulating thyroid and skeletal muscle antibodies. Amer. J. Med. 43, 956 (1967)

    Google Scholar 

  • Brunet, P., Moulias, R.: Facteurs immunologiques des polyradiculonévrites inflammatoires. Nouv. Presse méd. 1, 2443 (1972)

    Google Scholar 

  • Caspary, L., Curie, S., Walton, J., Field, E. J.: Lymphocyte sensitization to nervous tissues and muscle in patients with the Guillain-Barré syndrome. J. Neurol. Neurosurg. Psychiat. 34, 179 (1971)

    Google Scholar 

  • Castaigne, P., Berthaux, P., Brunet, P., Moulias, R., Goust, J.-M., Delrieu, F.: Polyradiculonévrites inflammatoires et immunité cellulaire: Etude de la résponse immunitaire cellulaire envers des antigènes de nerf periphérique par le test de migration des leucocytes. Nouv. Presse méd. 1, 2445 (1972)

    Google Scholar 

  • Cook, S. D., Dowling, P. C., Murray, M. R., Whitaker, J. N.: Circulating demyelinating factors in acute idiopathic polyneuropathy. Arch. Neurol. 24, 136 (1971)

    Google Scholar 

  • Cook, S. D., Dowling, P. C., Whitaker, J. N.: The Guillain-Barré syndrome. Relationship of circulating immunocytes to disease activity. Arch. Neurol. 22, 470 (1970)

    Google Scholar 

  • Cook, S. D., Murray, M. R., Whitaker, J. N., Dowling, P.: Myelinotoxic antibody in the Guillain-Barré syndrome. Neurology (Minneap.) 19, 284 (1969)

    Google Scholar 

  • Daly, J. J., Jackson, E.: Case of Hashimoto's disease with myasthenia gravis. Brit. med. J. 1964 I, 748

    Google Scholar 

  • Doniach, D., Roitt, I. M.: Auto-immunity in Hashimoto's disease and its implications. J. clin. Endocr. 17, 1293 (1957)

    Google Scholar 

  • Doniach, D., Roitt, I. M.: An evaluation of gastric and thyroid auto-immunity in relation to hematologic disorders. Sem. Hemat. 1, 313 (1964)

    Google Scholar 

  • Goodall, J. A. D., Kosmidis, J. C., Geddes, A. M.: Effect of corticosteroids on course of Guillain-Barré syndrome. Lancet 1974 I, 524

    Google Scholar 

  • Irvine, W. J., Davis, S. H., Delamore, I. W., Williams, A. W.: Immunological relationship between pernicious anemia and thyroid disease. Brit. med. J. 1962 II, 454

    Google Scholar 

  • Knowles, M., Saunders, M., Currie, S., Walton, J. N., Field, E. J.: Lymphocyte transformation in the Guillain-Barré syndrome. Lancet 1969 II, 1168

    Google Scholar 

  • Lord Brain, Jellinek, E. H., Ball, K.: Hashimoto's disease and encephalopathy. Lancet 1966 II, 512

    Google Scholar 

  • Luijten, J. A. F. M., Baart de la Faille-Kuyper, E. H.: The occurrence of IgM and complement factors along myelin sheaths of peripheral nerves. An immunohistochemical study of the Guillain-Barré syndrome. Preliminary communication. J. neurol. Sci. 15, 219 (1972)

    Google Scholar 

  • Markson, J. L., Moore, J. M.: Thyroid autoantibodies in pernicious anaemia. Brit. med. J. 1962 II, 1352

    Google Scholar 

  • Martin, J. J., Philippart, M.: Ungewöhnliche Verlaufsformen der Polyradikuloneuritis mit Liquordissoziation (Typ Guillain-Barré). Wld Neurol. 3, 409 (1962)

    Google Scholar 

  • Matthews, W. B., Howell, D. A., Hughes, R. C.: Relapsing corticosteroid-dependent polyneuritis. J. Neurol. Neurosurg. Psychiat. 33, 330 (1970)

    Google Scholar 

  • McQuillen, M. P.: Idiopathic polyneuritis: serial studies of nerve and immune functions. J. Neurol. Neurosurg. Psychiat. 34, 607 (1971)

    Google Scholar 

  • Melnick, S. C.: Thirty eight cases of the Guillain Barré syndrome: an immunological study. Brit. med. J. 1963 I, 368

    Google Scholar 

  • Moeschlin, S.: Klinische Demonstration neurologischer Fälle. Arteriitis temporalis, diffuse Vaskulitis mit Polyneuritis, Periarteriitis nodosa, Morbus Behçet, “Subclavian steal syndrome”, Wallenberg-Syndrom. Schweiz. med. Wschr. 99, 1632 (1969)

    Google Scholar 

  • Osserman, K. E., Tsairis, P., Weiner, L. B.: Myasthenia gravis and thyroid disease: Clinical and immunologic correlation. Fed. Proc. 25, 309 (1966)

    Google Scholar 

  • Prineas, J. W.: Demyelination and remyelination in recurrent idiopathic polyneuropathy. An electron microscope study. Acta neuropath. (Berl.) 18, 34 (1971)

    Google Scholar 

  • Reaves, L. E.: Altered immunologic mechanisms in diseases of unknown cause. Report of myasthenia gravis, pernicious anemia, and myxedema occuring in the same patient. Geriatrics 20, 707 (1965)

    Google Scholar 

  • Rocklin, R. E., Sheremata, W. A., Feldman, R. G., Kies, M. W., David, J. R.: The Guillain-Barré syndrome and multiple sclerosis. In vitro cellular responses to nervous-tissue antigens. New Engl. J. Med. 284, 803 (1971)

    Google Scholar 

  • Sahay, B. M., Blendis, L. M., Greene, R.: Relation between myasthenia gravis and thyroid disease. Brit. med. J. 1965 I, 762

    Google Scholar 

  • Sheremata, W. A., Rocklin, R. E., David, J.: Cellular hypersensitivity in Guillain-Barré syndrome. Canad. med. Ass. J. 110, 1245 (1974)

    Google Scholar 

  • Simpson, J. A.: Immunological disturbances in myasthenia gravis with a report of Hashimoto's disease developing after thymectomy. J. Neurol. Neurosurg. Psychiat. 27, 485 (1964)

    Google Scholar 

  • Singer, W., Sahay, B. M.: Myasthenia gravis, Hashimoto's thyroiditis, and pernicious anaemia. Brit. med. J. 1966 I, 904

    Google Scholar 

  • Taylor, K. B., Roitt, I. M., Doniach, D., Couchman, K. G., Shapland, C.: Autoimmune phenomena in pernicious anemia: gastric antibodies. Brit. med. J. 1962 II, 1347

    Google Scholar 

  • Thomas, P. K., Lascelles, R. G., Hallpike, J. F., Hewer, R. L.: Recurrent and chronic relapsing Guillain-Barré polyneuritis. Brain 92, 589 (1969)

    Google Scholar 

  • Tse, K. S., Arbesman, C. E., Tomasi, Th. B., Jr., Tourville, D.: Demonstration of antimyelin antibodies by immunofluorescence in Guillain-Barré syndrome. Clin. exp. Immunol. 8, 881 (1971)

    Google Scholar 

  • Tudhope, G. R., Wilson, G. M.: Anemia in hypothyroidism. Quart. J. Med. 29, 513 (1960)

    Google Scholar 

  • Vivo, D. C. de, Engel, W. K.: Remarkable recovery of a steroid-responsive recurrent polyneuropathy. J. Neurol. Neurosurg. Psychiat. 33, 62 (1970)

    Google Scholar 

  • Whitaker, J. N., Hirano, A., Cook, S. D., Dowling, P. C.: The ultrastructure of circulating immunocytes in Guillain-Barré syndrome. Neurology (Minneap.) 20, 765 (1970)

    Google Scholar 

  • Wiederholt, C. W., Mulder, D. W., Lambert, E. H.: The Landry-Guillain-Barré-Strohl syndrome or polyradiculoneuropathy: historical review, report on 97 patients and present concepts. Proc. Mayo Clin. 39, 427 (1964)

    Google Scholar 

  • Williams, E. D., Doniach, I.: The postmortem incidence of focal thyroiditis. J. Path. Bact. 83, 255 (1962)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurologische Klinik der Fakultät für klinische Medizin Mannheim der Universität Heidelberg, Germany

    G. Potz & B. Neundörfer

Authors
  1. G. Potz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Neundörfer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Potz, G., Neundörfer, B. Polyradicular neuritis and Hashimoto's thyroiditis. J. Neurol. 210, 283–289 (1975). https://doi.org/10.1007/BF00316529

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00316529

Key words

Search

Navigation