Skip to main content
SpringerLink
Log in

Development of mouse semilunar valves

  • Published:
Anatomy and Embryology Aims and scope Submit manuscript

Summary

The development of the semilunar valves of the great arteries of the mouse is studied by light and scanning electron microscopy. The earliest anlage of the valves is observed at day 11.5 of gestation, as three pairs of tubercles protruding towards the lumen of the truncus arteriosus. These early cusps consist of a core of mesenchymal tissue covered by the endocardium. From day 12.5 to 14 a process of excavation takes place in the arterial face of the cusps resulting in the achievement of their final shape. Our observations suggest that the excavation process is produced by a selective growth of the free edges of the cusps. Numerous pieces of evidence are reported suggesting that the selective growth of the cusps is due to an inductive interaction between the endocardium of the arterial face of the cusps and the underlying mesenchyme.

The histogenesis of the cusps takes place very late in development and possibly continues into the postnatal period.

The results are compared with studies made in other vertebrates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Anderson TF (1951) Techniques for preservation of three-dimensional structure in preparing specimens for electron microscope. Trans NY Acad Sci 13:130–134

    Google Scholar 

  • De la Cruz MV, Muñoz-Armas S, Muñoz-Castellanos L (1972) Development of the chick heart. The Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Hay DA, Low FN (1972) The fusion of dorsal and ventral endocardial cushions in the embryonic chick heart: A study in fine structure. Am J Anat 133:1–24

    Google Scholar 

  • Hurle JM (1979) Scanning and light microscope studies of the development of the chick embryo semilunar heart valves. Anat Embryol 157:69–80

    Google Scholar 

  • Hurle JM, Ojeda JL (1979) Cell death during the development of truncus and conus of the chick embryo heart. J Anat 129:427–439

    Google Scholar 

  • Hyams VJ, Manion WC (1968) Incomplete differentiation of the cardiac valves. Am Heart J 76:173–182

    Google Scholar 

  • Jaffe OC (1967) The development of the arterial outflow tract in the chick embryo heart. Anat Rec 158:35–42

    Google Scholar 

  • Kramer TC (1963) The partitioning of the truncus and conus and the formation of the membranous portion of the interventricular septum in the human heart. Am J Anat 71:343–370

    Google Scholar 

  • Markwald RR, Fitzharris TP, Adams Smith WN (1975) Structural analysis of endocardial cytodifferentiation. Dev Biol 42:160–180

    Google Scholar 

  • Markwald RR, Fitzharris TP, Bolender DL, Bernanke DH (1979) Structural analysis of cell-matrix association during the morphogenesis of atrioventricular cushion tissue. Dev Biol 69:634–654

    Google Scholar 

  • Paff GH, Boucek RJ, Gutten GS (1965) Ventricular blood pressures and competency of valves in the early embryonic heart. Anat Rec 151:119–124

    Google Scholar 

  • Patten BM, Kramer TC, Barry A (1948) Valvular action in the embryonic chick heart by localized apposition of endocardial masses. Anat Rec 102:299–311

    Google Scholar 

  • Pexieder T (1978) Development of the outflow tract of the embryonic heart. In: GC Rosenquist and D Bergsma (eds) Morphogenesis and malformation of the cardiovascular system. pp 29–68 Alan R Liss, New York

    Google Scholar 

  • Saunders JW Jr (1972) Developmental control of three dimensional polarity in the avian limb. Ann NY Acad Sci 193:29–42

    Google Scholar 

  • Shakibi JG, Diehl AM (1972) Postnatal development of the heart in normal Swiss-Webster mice. Lab Anim Sci 22:668–683

    Google Scholar 

  • Shaner RF (1962) Comparative development of the bulbus and ventricles of the vertebrate heart with special reference to Spitzer's theory of heart malformations. Anat Rec 142:519–529

    Google Scholar 

  • Shaner RF (1963) Abnormal pulmonary and aortic semilunar valves in embryos. Anat Rec 143:5–13

    Google Scholar 

  • Thompson RP, Fitzharris TP (1979) Morphogenesis of the truncus arteriosus of the chick embryo heart: The formation and migration of mesenchymal tissue. Am J Anat 154:545–556

    Google Scholar 

  • Tonge M (1869) Observations on the development of the semilunar valves of the aorta and pulmonary artery of the heart of the chick. Philos Trans R Soc Lon (Biol) 159:387–411

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Anatomía, Facultad de Medicina, Universidad de Santander, Santander, Spain

    J. M. Hurle, E. Colveé & A. M. Blanco

Authors
  1. J. M. Hurle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Colveé
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. M. Blanco
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hurle, J.M., Colveé, E. & Blanco, A.M. Development of mouse semilunar valves. Anat. Embryol. 160, 83–91 (1980). https://doi.org/10.1007/BF00315651

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00315651

Key words

Search

Navigation