Summary
Seventeen patients underwent tonsillectomy 55–120 min after recieving oral phenoxymenthylpenicillin 12.5 mg/kg bodyweight. The penicillin concentration in serum and tonsillar tissue in each patient was determined by a microbial assay. In 9 patients with tonsillar hyperplasia, but with no prior history of tonsillitis, the mean penicillin concentration in serum and in tonsillar tissue was 5.0 mg·1−1 and 1.32 mg·g−1, respectively, and in 8 patients with manifest tonsillitis the corresponding values were 3.01 mg·1−1 and 0.67 mg·g−1. It appears that the penicillin concentration in tonsillar tissue is about 1/5 to 1/4 of that in serum, regardless of whether the tonsils are inflamed or hypertrophied.
References
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Roos, K., Brorson, JE. Concentration of phenoxymethylpenicillin in tonsillar tissue. Eur J Clin Pharmacol 39, 417–418 (1990). https://doi.org/10.1007/BF00315423
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DOI: https://doi.org/10.1007/BF00315423