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Effect of haemodialysis on the pharmacokinetics of cetirizine

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Summary

The pharmacokinetics of Cetirizine, a histamine H1-receptor antagonist, were investigated in five renal failure patients undergoing chronic haemodialysis therapy. The patients received one 10 mg cetirizine dihydrochloride capsule 3 h before haemodialysis.

Concentrations of cetirizine in serum and dialysate were determined by HPLC. The maximum serum cetirizine concentration and the time to reach that maximum were 285 μg·1−1 and 2.0 h, respectively. The terminal disposition half-life of cetirizine in these patients was 19.3 h.

The haemodialysis clearance of cetirizine was 14.0 ml · min−1. Although this is approximately 33% of the apparent total body clearance of cetirizine in subjects with normal renal function, the fraction of the dose removed by dialysis was only 9.4%. Thus, since haemodialysis does not produce a clinically significantly alteration in cetirizine elimination, no supplemental dose should be necessary after dialysis.

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Authors and Affiliations

  1. The Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota, U.S.A.

    W. M. Awni, J. Yeh, C. E. Halstenson, J. A. Opsahl, M. Chung & G. R. Matzke

  2. College of Pharmacy and School of Medicine, University of Minnesota, Minneapolis, Minnesota, U.S.A.

    W. M. Awni, J. Yeh, C. E. Halstenson, J. A. Opsahl, M. Chung & G. R. Matzke

  3. Pfizer Pharmaceuticals, New York, New York, U.S.A.

    W. M. Awni, J. Yeh, C. E. Halstenson, J. A. Opsahl, M. Chung & G. R. Matzke

Authors
  1. W. M. Awni
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  2. J. Yeh
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  3. C. E. Halstenson
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  4. J. A. Opsahl
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  5. M. Chung
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  6. G. R. Matzke
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Awni, W.M., Yeh, J., Halstenson, C.E. et al. Effect of haemodialysis on the pharmacokinetics of cetirizine. Eur J Clin Pharmacol 38, 67–69 (1990). https://doi.org/10.1007/BF00314806

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  • DOI: https://doi.org/10.1007/BF00314806

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