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Intrathecal vincristine: a fatal chemotherapeutic error with devastating central nervous system effects

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Summary

The devastating neuropathological changes wrought by the intrathecal administration of vincristine are reported, with a detailed account of the widespread lesions in the brain and spinal cord, found in post-mortem light- and electron-microscope studies.

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Author notes

  1. P. G. Bain

    Present address: MRC Human Movement and Balance Unit, The Institute of Neurology, Queen Square, WC1N 3BG, London, UK

Authors and Affiliations

  1. Department of Neuropathology, Institute of Psychiatry, de Crespigny Park, Denmark Hill, SE5 8AF, London, UK

    P. G. Bain & P. L. Lantos

  2. Division of Forensic Medicine, The United Medical and Dental Schools of Guy's and St. Thomas's Hospitals, Guy's Hospital, SE1 9RT, London, UK

    V. Djurovic & I. West

Authors
  1. P. G. Bain
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  2. P. L. Lantos
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  3. V. Djurovic
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  4. I. West
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Bain, P.G., Lantos, P.L., Djurovic, V. et al. Intrathecal vincristine: a fatal chemotherapeutic error with devastating central nervous system effects. J Neurol 238, 230–234 (1991). https://doi.org/10.1007/BF00314787

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  • DOI: https://doi.org/10.1007/BF00314787

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