Skip to main content
Log in

Headaches and multiple sclerosis: a clinical study and review of the literature

  • Original Investigations
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Summary

Whether multiple sclerosis (MS) can cause headaches is controversial. To clarify the association between headaches and MS we prospectively analyzed 104 consecutive MS patients using detailed headache evaluations. Fifty-four patients (52%) reported headaches, compared with 5 of 35 (14%) patients initially suspected to have MS but subsequently proven to have other disorders, and 18 of 100 (18%) matched general neurology patients. The MS patients had tension headaches or vascular headaches of the migraine type; there was no distinctive “MS headache.” Seven of these patients had headaches with their first MS symptoms, but in only one did headaches recur with disease activity. Headaches did not correlate with any clinical features of MS. We conclude that an association between headaches and MS may exist.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Abb L, Schaltenbrand G (1956) Statistische Untersuchungen zum Problem der multiplen Sklerose. II. Mitteilung das Krankheitsbild der multiplen Sklerose. Dtsch Z Nervenheilkd 174:199–218

    Google Scholar 

  2. Adams DK, Sutherland JM, Fletcher WB (1950) Early clinical manifestations of disseminated sclerosis. Br Med J 2:431–436

    Google Scholar 

  3. Ad Hoc Committee of the National Institute of Neurological Diseases and Blindness (1962) Classification of headache. JAMA 179:173–176

    Google Scholar 

  4. Bonduelle M, Albaranes R (1962) Etude statistique de 145 cas de sclerose en plaque. Semin Hop Paris 68:3762–3773

    Google Scholar 

  5. Clifford DB, Trotter JL (1984) Pain in multiple sclerosis. Arch Neurol 41:1270–1272

    Google Scholar 

  6. Editorial: Headache in multiple sclerosis (1969) Br Med J 2:713–714

    Google Scholar 

  7. Freedman MS, Gray TA (1989) Vascular headache: a presenting symptom of multiple sclerosis. Can J Neurol Sci 16:63–66

    Google Scholar 

  8. Friedman AP (1989) Clinical approach to the patient with headache. Neurol Clin 1:361–368

    Google Scholar 

  9. Gilman-Sachs A, Robbins L, Baum L (1989) Flow cytometric analysis of lymphocyte subsets in peripheral blood of chronic headache patients. Headache 29:290–294

    Google Scholar 

  10. Hauser SL, Dawson DM, Lehrich JR, Beal MF, Kevy SV, Propper RD, Mills JA, Weiner HL (1983) Intensive immunosuppression in progressive multiple sclerosis. N Engl J Med 308:173–180

    Google Scholar 

  11. Hunter SB, Ballinger WE, Rubin JJ (1987) Multiple sclerosis mimicking primary brain tumor. Arch Pathol Lab Med 111:464–468

    Google Scholar 

  12. Kahana E, Leibowitz V, Alter M (1971) Cerebral multiple sclerosis. Neurology 21:1179–1185

    Google Scholar 

  13. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 33:1444–1452

    Google Scholar 

  14. Kurtzke JF, Beebe GW, Nagler B, Auth TL, Kurland LT, Nefzger MD (1968) Studies on natural history of multiple sclerosis. Acta Neurol Scand 44:467–494

    Google Scholar 

  15. McAlpine D, Compston ND (1952) Some aspects of the natural history of disseminated sclerosis. Q J Med 21:135–167

    Google Scholar 

  16. Nager BJ, Lanska DJ, Daroff RB (1989) Acute demyelination mimicking vascular hemicrania. Headache 29:423–424

    Google Scholar 

  17. Nelson MJ, Miller SL, McLain LW, Gold LHA (1981) Multiple sclerosis: large plaque causing mass effect and ring sign. J Comput Assist Tomogr 5:892–894

    Google Scholar 

  18. Niakan E, Rolak LA, Harati Y (1987) Quantitative measurement of autonomic function in patients with headaches. Neurology 37:239

    Google Scholar 

  19. Oger J, Roos R, Antel JP (1983) Immunology of multiple sclerosis. Neurol Clin 1:655–679

    Google Scholar 

  20. Poser CM (1987) Trauma and multiple sclerosis. An hypothesis. J. Neurol 234:155–159

    Google Scholar 

  21. Poser CM, Presthus J, Horsdal O (1966) Clinical characteristics of autopsy-proved multiple sclerosis. Neurology 16:791–798

    Google Scholar 

  22. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtelotte WW (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231

    Google Scholar 

  23. Sagar HJ, Warlow CP, Sheldon PWE, Esiri MM (1982) Multiple sclerosis with clinical and radiological features of cerebral tumor. J Neurol Neurosurg Psychiatry 45:802–808

    Google Scholar 

  24. Slater RJ, Raun NE (1984) Symposium on a minimal record of disability for multiple sclerosis. Acta Neurol Scand [Suppl 101]:1–217

    Google Scholar 

  25. Sterman AB, Coyle PK, Panasci D, Grimson R (1985) Disseminated cardiovascular autonomic abnormalities in multiple sclerosis. Neurology 35:314

    Google Scholar 

  26. Ragozzino MW, Melton LF (1984) Disease associations: Need for increased scrutiny of the literature. Mayo Clin Proc 59:719–721

    Google Scholar 

  27. Rieth KG, Chiro GD, Cromwell LD, McKeever PE, Kornblith PL, Kufta CV, Pleet AB (1981) Primary demyelinating disease simulating glioma of the corpus callosum. J Neurosurg 55:620–624

    Google Scholar 

  28. Riley T (1983) Muscle-contraction headache. Neurol Clin 1:489–500

    Google Scholar 

  29. Van Der Velden M, Bots GTAM, Endtz LJ (1979) Cranial CT in multiple sclerosis showing a mass effect. Surg Neurol 12:307–310

    Google Scholar 

  30. Waters WE, O'Connor PJ (1971) Epidemiology of headache and migraine in women. J Neurol Neurosurg Psychiatry 34:148–153

    Google Scholar 

  31. Watkins SM, Espir M (1969) Migraine and multiple sclerosis. J Neurol Neurosurg Psychiatry 32:35–37

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rolak, L.A., Brown, S. Headaches and multiple sclerosis: a clinical study and review of the literature. J Neurol 237, 300–302 (1990). https://doi.org/10.1007/BF00314746

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00314746

Key words

Navigation