Summary
A preliminary study is reported of clinical response and CSF/MRI findings in nine patients with multiple sclerosis receiving intravenous infusions of natural beta-interferon. The mean patient follow-up was for 1.2 years. Neither exacerbation rates nor CSF-IgG synthesis nor plaque formation as revealed by MRI showed a significant reduction during therapy. One patient developed a severe exacerbation of multiple sclerosis shortly after interferon infusion.
This is a preview of subscription content, log in via an institution to check access.
References
Bewermeyer H, Bamborschke S, Assheuer J, Dreesbach HA, Buchberger G, Neveling M, Mai JK, Heiß W-D (1986) Zusatzuntersuchungen zur Sicherung der Diagnose bei multipler Sklerose. Dtsch Med Wochenschr 111:1398–1405
Felgenhauer K, Hansen C, Remy A (1982) Laser-nephelometric evaluation of the humoral response in the central nervous system. Med Lab 11:48–57
Habif DV, Lipton R, Cantell K (1975) Interferon crosses blood brain barrier in monkeys. Proc Soc Exp Biol Med 149:28–98
Jacobs L, Salazar AM, Herndon R, Reese PA, Freeman A, Josefowicz R, Cuetter A, Husain F, Smith WA, Ekes R, O'Malley JA (1986) Multicentre double-blind study of effect of intrathecally administered natural human fibroblast interferon on exacerbations of multiple sclerosis. Lancet II:1411–1413
Knobler RL, Panitch HS, Braheny SL, Sipe JC, Rice GP, Huddlestone JR, Francis GS, Hooper CK, Kamin-Lewis RM, Johnson KP (1984) Systemic alpha-interferon therapy of multiple sclerosis. Neurology 34:1273–1279
Noseworthy JH, Seland TP, Ebers GC (1984) Therapeutic trials in multiple sclerosis. Can J Neurol Sci 11:355–362
Panitch HS, Francis GS, Hooper CJ, Merigan TC, Johnson KP (1985) Serial immunological studies in multiple sclerosis patients treated systemically with human alpha interferon. Ann Neurol 18:434–438
Poser CM, Paty DW, Scheinberg L, McDonal WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtelotte WW (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231
Rice GPA, Woelfel EL, Talbot PJ, Braheny SL, Sipe JC, Knobler RL, Merigan TC, Oldstone MBA (1985) Immunological complications in multiple sclerosis patients receiving interferon. Ann Neurol 18:439–442
Tourtelotte WW (1975) What is multiple sclerosis? Laboratory criteria for diagnosis. In: Davidson AN, Humphrey JH, Liversedge AL, Potterfield JS (eds) Multiple sclerosis research. Elsevier, New York, pp 9–26
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Huber, M., Bamborschke, S., Assheuer, J. et al. Intravenous natural beta interferon treatment of chronic exacerbating-remitting multiple sclerosis: clinical response and MRI/CSF findings. J Neurol 235, 171–173 (1988). https://doi.org/10.1007/BF00314311
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00314311