Summary
The effect of short-term intensive cyclophosphamide therapy upon 21 patients with moderately advanced multiple sclerosis is compared with a non-treated control group of 21 patients retrospectively matched for global disability. The progression of the disease was evaluated by regular disability scoring, and the results were analyzed by non-parametric statistical tests. No significant differences in the progression of the disability could be detected during a follow-up period of 2 years.
Zusammenfassung
Die Wirksamkeit von kurzzeitiger intensiver Cyclophosphamid-Therapie bei 21 Multiple-Sklerose-Kranken wurde im Vergleich zu 21 Kranken mit ähnlichen Funktionsausfällen in einer retrospektiven Studie untersucht. Der Krankheitsverlauf wurde mit regelmäßigen Untersuchungen registriert und nach einem Punktsystem bewertet. Diese Ergebnisse wurden mit nicht-parametrisch statistischen Tests analysiert. Die mittlere Krankheitsprogression war während der Nachbeobachtungszeit von 24 Monaten in beiden Therapiegruppen niemals signifikant verschieden.
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References
Cendrowski WS (1971) Therapeutic trial of Imuran (azathioprine) in multiple sclerosis. Acta Neurol Scand 47:254–260
Cendrowski WS (1973) Combined therapeutic trial in multiple sclerosis: hydrocortisone hemisuccinate with cyclophosphamide or cytosine arabinoside. Acta Neurol Belg 73:209–219
Ellison GW, Myers LW (1978) A review of systemic immunosuppressive treatment of multiple sclerosis. Neurology (Minneap) 28:132–139
Gonsette R, Demonty L, Delmotte P (1977) Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2–6 years. J Neurol 214:173–181
Hommes OR, Prick JJG, Lamers KJB (1975) Treatment of the chronic progressive form of multiple sclerosis with a combination of cyclophosphamide and prednisone. Clin Neurol Neurosurg 59:
Hommes OR, Lamers KJB, Prick JJG (1977) Immunosuppression in 54 patients with chronic progressive multiple sclerosis. In: Hartog Jaeger WA den, Bruyn GW, Heystee APJ (eds) Abstracts Eleventh World Congress of Neurology, International Congress Series No 427. Amsterdam Oxford, Excerpta Medica, p 331
Ketelaer P, Van Diest R, Van Muysewinkel A, Van Geyseghem L, Keersmaekers A, Delaite D, Leroy Y, Clou P, Droissart Chr (1978) Evaluation and results of the rehabilitation in multiple sclerosis. Belgisch Tijdschrift voor Fysische Geneeskunde en Rehabilitatie 1:227–246
Kurtzke JF (1965) Further notes on disability evaluation in multiple sclerosis, with scale modifications. Neurology (Minneap) 15:654–661
Patzold U, Pocklington P (1980) Azathioprine in multiple sclerosis — A 3 year controlled study of its effectiveness. J Neurol 223:97–117
Rosen JA (1979) Prolonged azathioprine treatment of nonremitting multiple sclerosis. J Neurol Neurosurg Psychiat 42:338–344
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Theys, P., Gosseye-Lissoir, F., Ketelaer, P. et al. Short-term intensive cyclophosphamide treatment in multiple sclerosis. J Neurol 225, 119–133 (1981). https://doi.org/10.1007/BF00313325
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DOI: https://doi.org/10.1007/BF00313325