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Is there a causal connection between bile acids and colorectal cancer?

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Abstract

Bile acid composition was assessed in 50 patients with colorectal cancer as compared to that in a control group of 50 subjects. The two groups were age- and sex-matched. The overall bile acid values were similar in both groups, while the relative concentrations of primary and secondary bile acids were different, a significant increase in the patients with colorectal cancer being observed. This finding thus seems to confirm the existence of a link between colorectal cancer and cholelithiasis. Both conditions share common risk factors, such as alterations in cholesterol metabolism and bile acid composition.

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Authors and Affiliations

  1. First Department of Surgery, University of Rome “La Sapienza,” Viale del Policlinico, 00161, Rome, Italy

    Adriano Tocchi, Luigi Basso, Gianluca Costa, Luca Lepre, Gianluca Liotta, Gianluca Mazzoni, Adalgisa Sita & Sandro Tagliacozzo

Authors
  1. Adriano Tocchi
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  2. Luigi Basso
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  3. Gianluca Costa
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  4. Luca Lepre
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  5. Gianluca Liotta
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  6. Gianluca Mazzoni
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  7. Adalgisa Sita
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  8. Sandro Tagliacozzo
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Tocchi, A., Basso, L., Costa, G. et al. Is there a causal connection between bile acids and colorectal cancer?. Surg Today 26, 101–104 (1996). https://doi.org/10.1007/BF00311772

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  • DOI: https://doi.org/10.1007/BF00311772

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