Abstract
The het-c locus of the filamentous fungus Podospora anserina controls heterokaryon formation through genetic interaction with alleles of the unlinked loci het-e and het-d. We have isolated four wild-type and two mutant alleles of the het-c locus. A comparison of the predicted proteins encoded by the different wild-type alleles revealed an unusual high level of amino-acid replacements compared to silent polymorphisms but only one amino-acid difference is sufficient to modify the specificity of het-c alleles. Chimeric genes constructed in vitro may exhibit a new specificity different from that of any known wild-type allele.
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Communicated by P. P. Slonimski
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Saupe, S., Turcq, B. & Bégueret, J. Sequence diversity and unusual variability at the het-c locus involved in vegetative incompatibility in the fungus Podospora anserina . Curr Genet 27, 466–471 (1995). https://doi.org/10.1007/BF00311217
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DOI: https://doi.org/10.1007/BF00311217