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Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788

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Abstract

The imidazodiazepine Ro 15-1788 is a benzodiazepine receptor antagonist that was initially reported to be lacking in intrinsic activity in a variety of test situations in which benzodiazepine-like effects can be identified. However, many recent studies have shown that this compound does indeed have intrinsic activity in a variety of behavioural, neurological, electrophysiological and biochemical preparations in both animals and man. The purpose of the present review is firstly to describe these intrinsic actions, and secondly to consider to what extent these intrinsic actions of Ro 15-1788 have implications for current concepts of the functioning of the benzodiazepine receptor.

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  1. Sandra E. File

    Present address: Départment de Pharmacologie, Faculté de Mecinine Pitié-Salpétrière, 75634, Paris Cédex, France

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  1. MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK

    Sandra E. File & Sharon Pellow

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File, S.E., Pellow, S. Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacologia 88, 1–11 (1986). https://doi.org/10.1007/BF00310505

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