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Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma

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Summary

To assess the capacity of transitional cells to synthesize and release polymeric immunoglobulin receptor (pIg-R) in bladder carcinoma, we studied the localization of pIg-R in normal and tumor tissues and measured the levels of secretory component (SC) either in the free form or bound to Ig (S-IgA, S-IgM) in the serum and urine of 56 patients with transitional-cell carcinoma (TCC) of the bladder. In the normal bladder mucosa, pIg-R was localized in the cytoplasm and plasma membranes of the superficial cells and on all epithelial cell membranes. In TCC cases, 65% of those studied expressed pIg-R. A marked heterogeneity in pIg-R staining was observed in some tumors. Although a better expression of pIg-R in tumors with a well-preserved epithelial architecture was observed, no correlation was found between pIg-R expression and the grade or stage of the tumors in the patients under study. Three groups were established: (1) in TCC with no complications, serum levels of free SC and S-IgA were significantly increased; (2) in TCC with urinary infections (UI), serum levels of free SC and S-IgA were significantly higher than control values but lay within the same range observed in TCC with no complications and rates of urinary excretion of SC were significantly higher than those in normal subjects; (3) in TCC without UI but with hepatic disorders [high gamma-glutamyl transferase (GGT) activity], there was a correlation between serum S-IgA levels and GGT activity (r=0.5, P<0.005) and serum SC levels were significantly higher than those observed in the other groups. Whereas urinary SC levels appear to reflect urinary infection, serum SC levels, albeit influenced by the hepatic status, may be an additional marker of TCC of the bladder.

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References

  1. Balish M, Jensen U, Uehling D (1982) Bladder mucin: as scanning electron microscopy study in experimental cystitis. J Urol 128: 1060

    Google Scholar 

  2. Ben-Aïssa H, Paulie S, Gustafsson B, Hakansson L, Lagerkvist M, Gustafson H, Ahlstrand C, Perlmann P (1988) Human bladder cancer associated antigen: evaluation of antigenicity in TCC tissues of different grades and in normal urothelium. Anticancer Res 8: 443

    Google Scholar 

  3. Brandtzaeg P (1985) Role of J chain and secretory component in receptor mediated glandular and hepatic transport of immunoglobulins in man. Scand J Immunol 22: 111

    Google Scholar 

  4. Brooks JJ, Ernst CS (1984) Immunoreactive secretory component of IgA in human tissues and tumors. Am J Clin Pathol 82: 660

    Google Scholar 

  5. Brown JL, Russell PJ, Philips J, Wotherspoon J, Raghavan D (1990) Clonal analysis of a bladder cancer cell line: an experimental model of tumor heterogeneity. Br J Cancer 61: 369

    Google Scholar 

  6. Delacroix D, Vaerman JP (1981) A solid phase, direct competition radioimmunoassay for quantitation of secretory IgA in human serum. J Immunol Methods 40: 345

    Google Scholar 

  7. Franke W, Schiller D, Moll R, Winter S, Schmidt E, Engelbrecht I, Denk H, Krepler R, Platzer B (1981) Diversity of cytokeratins: differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J Mol Biol 153: 933

    Google Scholar 

  8. Gotoh T, Takishita Y, Doi H, Tsubura E (1981) Secretory component-producing lung cancer with hypergammaglobulinemia of secretory IgA. Cancer 48: 1776

    Google Scholar 

  9. Harris JP, South MA (1981) Secretory component. A glandular epithelial cell marker. Am J Pathol 105: 47

    Google Scholar 

  10. Ishiguro Y, Kanefusa K, Takahiro I (1981) Sensitive solid phase enzyme immunoassay for human IgA, secretory IgA and secretory component. Clin Chim Acta 116: 237

    Google Scholar 

  11. Kew MC, Vincent C, Rossel M, Revillard JP (1989) High serum levels of secretory component in hepatocellular carcinoma. Am J Med 85: 327

    Google Scholar 

  12. Kirkham N, Maciver AG, Anscombe AM (1983) The secretory immune system in urothelial neoplasia. Diagn Histopathol 6: 85

    Google Scholar 

  13. Kuriyama M (1979) The study of urinary secretory IgA: I. Its localization in the urinary tract. Jpn J Urol 70:1129

    Google Scholar 

  14. Kvale D, Brandtzaeg P (1986) An enzyme-linked immunosorbent assay for differential quantitation of secretory immunoglobulins of the A and M isotypes in human serum. J Immunol Methods 86: 107

    Google Scholar 

  15. Kvale D, Rognum TO, Brandtzaeg P (1987) Elevated levels of secretory immunoglobulins A and M in serum of patients with large-bowel carcinoma indicate liver metastasis. Cancer 59: 203

    Google Scholar 

  16. Kvale D, Rognum TO, Thorud, E, Fossa SD, Brandtzaeg P (1987) Circulating secretory component in breast neoplasms. J Clin Pathol 40: 621

    Google Scholar 

  17. Lamy B, Vago P, Billerey C, Bittard H, Bureau JP (1990) Flow cytometry and bladder cancer. Cah Cancer 2: 208

    Google Scholar 

  18. Lee YS, Raju GC (1988) Expression of IgA and secretory component in the normal and in adenocarcinoma of Fallopian tube, endometrium and endocervix. Histopathology 13: 67

    Google Scholar 

  19. Marx M, Weber M, Schfranek D, Waubel E, Meyer Zum Büschenfelde KH, Köhler H (1989) Secretory immunoglobulin A in chronic urinary tract infection, glomerulonephritis and renal transplantation. Clin Immunol Immunopathol 53: 181

    Google Scholar 

  20. Moll R, Achtstätter T, Becht E, Ballarova-Ständer J, Ittensohn M, Franke W (1988) Cytokeratins in normal and malignant transitional epithelium. Am J Pathol 132: 123

    Google Scholar 

  21. Mostofi FK, Sobrin LH, Torloni H (1973) Histological typing of urinary bladder tumors. In: international histological classification of tumors, vol. 10. World Health Organization, Geneva, p 15

    Google Scholar 

  22. Mostov KE, Blobel G (1982) A transmembrane precursor of secretory component, the receptor transport of polymeric immunoglobulins. J Biol Chem 257: 11816

    Google Scholar 

  23. Pocock RD, Ibrahim SK, Sloane JP, Ponder AJ, Sheaner RJ (1983) Potential value of antisera to epithelial membrane antigen in detecting early invasion in transitional carcinoma. Br J Urol 55: 670

    Google Scholar 

  24. Poger ME, Hirsch BR, Lamm ME (1976) Synthesis of secretory component by colonic neoplasms. Am J Pathol 82: 327

    Google Scholar 

  25. Puleo EA, Haagsen DE, Dawson JR, Gall SA (1979) Study of secretory component in patients with metastatic breast cancer. Gut 23: 475

    Google Scholar 

  26. Rosengard A, Krutzsch H, Shearn A, Biggs J, Barker E, Margulies I, King R, Liotta L, Steeg P (1989) Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature 342: 177

    Google Scholar 

  27. Stern EA, Underdown BJ, Crichlow RW, Wira CR (1985) Secretory component in breast cancer. Analysis of the levels in primary and metastatic disease. Cancer Immunol Immunother 19: 226

    Google Scholar 

  28. Takashi M, Murase T, Mitsuya H, Koshikawa T, Natura H, Haimoto H (1986) Immunohistochemical localization of epithelial membrane antigen, carcinoembryonic antigen and secretory component in urinary bladder cancer. Hinyokika Kiyo 32: 541

    Google Scholar 

  29. Trinchieri A, Braceshi D, Tiranti D, Dell'Acqua S, Mandressi A, Pisani E (1990) Secretory immunoglobulin A and inhibitory activity of bacterial adherence to epithelial cells in urine from patients with urinary tract infections. Urol Res 18: 305

    Google Scholar 

  30. Vincent C, Revillard JP (1988) Sandwich-type ELISA for free and bound secretory component in human biological fluids. J Immunol Methods 106: 153

    Google Scholar 

  31. Viola M, Fromowitz F, Oravez S, Deb S, Schlom J (1985) Ras oncogene p21 expression is increased in premalignant lessions and high-grade bladder carcinoma. J Exp Med 161: 1213

    Google Scholar 

  32. Vuitton DA, Seilles E, Cozon G, Rossel M, Bresson-Hadni S, Revillard JP (1991) Secretory IgA in hepatobiliary discases. Surv Dig Dis (in press)

  33. Wahren B, Edsmyr F (1978) Carcinoembryonic antigen in serum, urine and cells of patients with bladder carcinoma. Urol Res 6: 221

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire Universitaire d'Immunologie, Faculté de Médicine, Centre Hospitalier Universitaire, Besançon, France

    M. Rossel & D. A. Vuitton

  2. Service d'Anatomie Pathologique, Centre Hospitalier Universitaire, Besançon, France

    C. Billerey

  3. Service d'Urologie, Centre Hospitalier Universitaire, Besançon, France

    H. Bittard & P. Ksiazek

  4. Service de Médecine Biochimie, Centre Hospitalier Universitaire, Besançon, France

    D. Alber

  5. Unité INSERM 80/CNRS URA 1177, Lyon, France

    J. -P. Revillard

Authors
  1. M. Rossel
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  2. C. Billerey
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  3. H. Bittard
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  4. P. Ksiazek
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  5. D. Alber
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  6. J. -P. Revillard
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  7. D. A. Vuitton
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Rossel, M., Billerey, C., Bittard, H. et al. Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma. Urol. Res. 19, 361–366 (1991). https://doi.org/10.1007/BF00310151

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  • DOI: https://doi.org/10.1007/BF00310151

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