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Increased heterozygote frequency in certain regions of the T4-chromosome

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Summary

The frequency of partial heterozygotes was measured at different points of the T4 chromosome, using am- and rII-mutants. Two to three times more heterozygotes were formed in gene 34 and in gene 25 than in the rII-region or gene 23 resp. This finding is interpreted to be a consequence of increased recombination frequency in certain regions of the T4 DNA-molecule, in agreement with two other, independent sets of data (Womack, 1965; Mosig, 1966).

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Literature

  • Berger, H.: Genetic analysis of T4D phage heterozygotes produced in the presence of 5-fluorodeoxyuridine. Genetics 52, 729 (1965).

    Google Scholar 

  • Brenner, S., A. O. W. Stretton, and S. Kaplan: Genetic code: The “nonsense” triplets for chain termination and their suppression Nature (Lond.) 206, 994 (1965).

    Google Scholar 

  • Champe, S. P., and S. Benzer: An active cistron fragment. J. molec. Biol. 4, 288 (1962).

    Google Scholar 

  • Edgar, R. S., G. H. Denhardt, and R. H. Epstein: A comparative genetic study of conditional lethal mutations of bacteriophage T4D. Genetics 49, 635 (1964).

    Google Scholar 

  • Edgar, R. S., and W. B. Wood: Morphogenesis of bacteriophage T4 in extract of mutant-infected cells. Proc. nat. Acad. Sci. (Wash.) 55, 498 (1966).

    Google Scholar 

  • Epstein, R. H., A. Bolle, C. M. Steinberg, E. Kellenberger, E. Boy de la Tour, R. Chevalley, R. S. Edgar, M. Susman, G. H. Denhardt, and A. Lielausis: Physiological studies of conditional lethal mutants of bacteriophage T4D. Cold Spr. Harb. Symp. quant. Biol. 28, 375 (1963).

    Google Scholar 

  • Hertel, R.: Gene function of heterozygotes in phage T4. Z. Vererbungsl. 96, 105 (1965).

    Google Scholar 

  • Jordan, E., and M. Meselson: A discrepancy between genetic and physical lengths on the chromosome of bacteriophage lambda. Genetics 51, 77 (1965).

    Google Scholar 

  • Krieg, D. R.: A study of gene action in ultraviolet-irradiated bacteriophage T4. Virology 8, 80 (1959).

    Google Scholar 

  • Meselson, M.: The molecular basis of genetic recombination Mendel Centennial Symp. Genetical Soc. U.S. (1966) (in press).

  • Michalke, W.: Erhöhte Rekombinationshäufigkeit an den Enden des T1-Chromosoms. Molec. Gen. Genetics 99, 12 (1967).

    Google Scholar 

  • Mosig, G.: Distances separating genetic markers in T4-DNA. Proc. nat. Acad. Sci. (Wash.) 56, 1177 (1966).

    Google Scholar 

  • Olligs, H.: Versuche zur Rekombination mit dichtemarkierten T1-Phagen Diss. Köln 1967.

  • Shalitin C., and F. W. Stahl: Additional evidence for two kinds of heterozygotes in phage T4. Proc. nat. Acad. Sci. (Wash.) 54, 1340 (1965) and pers. comm. 1965a.

    Google Scholar 

  • Stahl, F. W., R. S. Edgar, and J. Steinberg: The linkage map of bacteriophage T4. Genetics 50, 539 (1964).

    Google Scholar 

  • Steinberg, C., and F. W. Stahl: The clone-size distribution of mutants arising from a steady-state pool of vegetative phages. J. theoretical Biol. 1, 488 (1961).

    Google Scholar 

  • Thomas jr., C. A.: The arrangement of information in DNA-molecules. J. gen. Physiol. 49, Suppl. 143 (1966).

    Google Scholar 

  • Whitehouse, H. L. H., and P. J. Hastings: The analysis of genetic recombination on the polaron hybrid DNA model. Genet. Res. 6, 27 (1965).

    Google Scholar 

  • Wiemann, J.: Zur Charakterisierung von Heterozygoten des Phagen T4. Z. Vererbungsl. 97, 81 (1965).

    Google Scholar 

  • Womack, F. C.: Cross-reactivation differencs in bacteriophage T4D. Virology 26, 758 (1965).

    Google Scholar 

  • —: Radiation-genetic evidence that only one of the two DNA strands injected by phage T4 transmits the genetic information to progeny. Virology 27, 600 (1965).

    Google Scholar 

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Rottländer, E., Hermann, K.O. & Hertel, R. Increased heterozygote frequency in certain regions of the T4-chromosome. Molec. Gen. Genetics 99, 34–39 (1967). https://doi.org/10.1007/BF00306455

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