Summary
The aliphatic nitrosamines dimethylnitrosamine (DMN), diethylnitrosamine (DEN), dipropylnitrosamine (DPN), and dibutylnitrosamine(DBN) reached fetal tissue in quantitatively measurable amounts after subcutaneous administration to pregnant Syrian hamsters. The compounds were present for at least 2 h in maternal blood, placenta, fetus, and amniotic fluid; DBN was still measurable after 6 h. Only a weak or borderline transplacental effect was seen when incidences and latencies of neoplasms in the respiratory and digestive tracts of the F1-generation were compared with those of the P-generation after exposure to a single dose of DMN or DPN. However, some tumor types occurred at relatively high rates in the young, but were seen only occasionally in their mothers or in this hamster colony in general.
Zusammenfassung
Die aliphatischen Nitrosamine Dimethylnitrosamin (DMN), Diäthylnitrosamin (DEN), Dipropylnitrosamin (DPN) und Dibutylnitrosamin (DBN) erreichen nach subcutaner Verabreichung an trächtige, Syrische Hamster in quantitativ bestimmbaren Mengen das fetale Gewebe. Die Verbindungen waren im mütterlichen Blut, in Placenta, Fetus und Fruchtwasser wenigstens 2 Std nachweisbar; DBN zeigte meßbare Werte noch nach 6 Std. Der Vergleich der Häufigkeit und Latenzzeit der Tumoren, die in den Luftwegen und im Verdauungstrakt der F1-Generation gefunden wurden, mit denen in der P-Generation nach Behandlung mit einer Einzeldosis von DMN oder DPN ließ nur eine schwache oder grenzwertige, transplacentare Wirkung erkennen. Jedoch entwickelten sich bei den Jungen einige Tumorarten, die nur gelegentlich bei den Müttern oder anderen Hamstern dieser Kolonie gefunden wurden.
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Supported by U.S. Public Health Service Contract NO1 CP33278 from the National Cancer Institute, NIH
The authors thank K.Muffly and D. Ogrowsky for technical assistance, J. Villareal for graphic illustration and M. Susman for editorial help
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Althoff, J., Pour, P., Grandjean, C. et al. Transplacental effects of nitrosamines in Syrian hamsters. Z. Krebsforsch. 90, 79–86 (1977). https://doi.org/10.1007/BF00306022
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DOI: https://doi.org/10.1007/BF00306022