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Carcinome in Papillären Cystadenolymphomen der Parotis Definition und Differentialdiagnose

Carcinomas in papillary cystadenolymphomas of the parotid gland — definition and differential diagnosis

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Summary

Within a collective of 1431 salivary gland tumors of the salivary gland register (1965–1976) an observation has been done, which has been classified as a “carcinoma in a papillary cystadenolymphoma”. Corresponding to the “carcinoma in a pleomorphous adenoma” of the WHO-classification of salivary gland tumors the terminus “carcinoma in a cystadenolymphoma” is further defined. 6 additional cases from the literature are reviewed. The possible role of epithelial metaplasia and of a preceding radiation in the development of carcinomas in cystadenolymphomas are discussed. The following other tumors have to be differentiated from a carcinoma in a cystadenolymphoma: Metastases of other tumors beyond a cystadenolymphoma; malignant lymphoepithelial lesions (predominantly malignant lymphomas in a preexisting immune-sialadenitis of the myoepithelial sialadenitis type; rare carcinomas), and lymphoepitheliomas.

Zusammenfassung

In einem Gesamtkollektiv von 1431 Speicheldrüsentumoren des Speicheldrüsenregisters (1965–1976) wurde eine Beobachtung registriert, welche als „Carcinom in einem papillären Cystadenolymphom“ klassifiziert wurde. In Parallele zum „Carcinom in einem pleomorphen Adenom“ der WHO-Klassifikation der Speicheldrüsentumoren wird der Begriff „Carcinom in einem Cystadenolymphom“ näher definiert. Zugleich werden auch 6 weitere Beobachtungen des Weltschrifttums zusammengestellt. Die mögliche Rolle von Epithelmetaplasien und der Einfluß einer vorausgegangenen Strahlentherapie auf die Carcinomentstehung in Cystadenolymphomen werden diskutiert. Differentialdiagnostisch müssen folgende andere Tumorformen vom Carcinom in einem Cystadenolymphom abgegrenzt werden: Metastasen eines anderen Primärtumors außerhalb eines Cystadenolymphoms mit Metastasierung in ein Cystadenolymphom; maligne lymphoepitheliale Läsionen (vorwiegend maligne Lymphome bei einer vorbestehenden Immun-Sialadenitis vom Typus einer myoepithelialen Sialadenitis, seltener Carcinome) und Lymphoepitheliome.

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Literatur

  • Arthaud,J.B.: Anaplastic parotid carcinoma (“malignant lympho-epithelial lesion”) in seven Alaskan natives. Amer. J. clin. Path. 57, 275 (1972)

    Google Scholar 

  • Assor,D.: Bilateral carcinoma of the parotid, one cancer arising in a Warthin's tumor. Amer. J. clin. Path. 61, 270 (1974)

    Google Scholar 

  • Astacio,J.N.: Papillary cystadenoma lymphomatosum associated with pleomorphic adenoma of the parotid gland. Oral Surg. 38, 91 (1974)

    Google Scholar 

  • Baues,A.M.: Radiation as a carcinogenic agent. Radiation Res. 3, 272 (1955)

    Google Scholar 

  • Belsky,J.L., Takeichi,N., Yamamoto,T., Cihak,R.W., Hirose,F., Ezaki,H., Salivary gland neoplams following atomic radiation: additional cases and reanalysis of combined data in a fixed population 1957–1970. Cancer (Philad.) 35, 555 (1975)

    Google Scholar 

  • Berg,J.W., Hutter,R.V.P., Foote,F.W.,jr.: The unique association between salivary gland cancer and breast cancer. J. Amer. med. Ass. 204, 771 (1968)

    Google Scholar 

  • Delaney,W.E., Balogh,K., jr.: Carcinoma of the parotid gland associated with benign lymphoepithelial lesion (Mikulicz's disease) in Sjögren's syndrome. Cancer (Philad.) 19, 853 (1966)

    Google Scholar 

  • Doebroessy,L., Ronay,P., Molnar,L.: Malignant papillary cystadenoma lymphomatosum. Oncology 26, 457 (1972)

    Google Scholar 

  • Donath,K., Seifert,G.: Ultrastruktur und Pathogenese der myoepithelialen Sialadenitis. Virchows Arch. Abt. A 356, 315 (1972)

    Google Scholar 

  • Eneroth,C.M., Blanck,C., Jacobsson,P.A.: Carcinoma in pleomorphic adenoma of the parotid gland. Acta oto-laryng. 66, 477 (1968)

    Google Scholar 

  • Evans,R.W., Cruickshank,A.H.: Epithelial tumours of the salivary glands. Philadelphia-London Toronto: Saunders 1970

    Google Scholar 

  • Gadient,St.E., Kalfayan,B.: Mucoepidermoid carcinoma arising within a Warthin's tumor. Oral Surg. 40, 391 (1975)

    Google Scholar 

  • Gaston,E.A., Tedeschi,C.G.: Adenolymphoma of the parotid and submaxillary salivary gland. Ann. Surg. 123, 1075 (1946)

    Google Scholar 

  • Geiler,G.: Zur Pathogenese der Adenolymphome. Virchows Arch. path. Anat. 330, 172 (1957)

    Google Scholar 

  • Gläser,A.: Die Adenolymphome. Zbl. Chir. 86, 77 (1961)

    Google Scholar 

  • Hanford,J.M.: Branchiogenic adenoma of the neck. Ann. Surg. 94, 461 (1931)

    Google Scholar 

  • Heckmayr,M., Seifert,G.: Hämatogene Metastasen bei pleomorphen Speicheldrüsenadenomen. Laryng. Rhinol. 56, 19 (1977)

    Google Scholar 

  • Heckmayr,M., Seifert,G., Donath,K.: Maligne Lymphome und Immunsialadenitis. Laryng. Rhinol. 55, 593 (1976)

    Google Scholar 

  • Hilderman,W.C., Gordon,J.S., Large,H.L., Caroll,C.F., jr.: Malignant lymphoepithelial lesion with carcinomatous component apparently arising in parotid gland. A malignant counterpart of benign lymphoepithelial lesion. Cancer (Philad.) 15, 606 (1962)

    Google Scholar 

  • Iannaccone,Ph.: Multiple primary tumors. Four distinct head and neck tumors. Arch. Path. (Chicago) 99, 270 (1975)

    Google Scholar 

  • Jensen,P. St., Husted,E.: Cystadenolymphoma (Warthin's tumor) of the parotid gland. Scand. J. plast. reconstr. Surg. 4, 114 (1970)

    Google Scholar 

  • Kavka,S.J.: Bilateral simultaneous Warthin's tumors. Arch. Otolaryng. 91, 302 (1970)

    Google Scholar 

  • Kessler,E., Kznizky,I.L., Schindel,J.: Malignant Warthin's tumor. Oral Surg. 43, 111 (1977)

    Google Scholar 

  • Kleinsasser,O.: Über das Sebaceolymphom der Parotis. Mschr. Ohrenheilk. 98, 318 (1964)

    Google Scholar 

  • Kleinsasser,O., Klein,H.J., Steinbach,E., Hübner,G.: Onkocytäre adenomartige Hyperplasien, Adenolymphome und Onkocytome der Speicheldrüsen. Arch. klin. exp. Ohr.-, Nas.- u. Kehlk.-Heilk. 186, 317 (1966)

    Google Scholar 

  • Lederman,M.: Adenolymphoma of the parotid salivary gland. Brit. J. Radiol. 16, 383 (1943)

    Google Scholar 

  • Little,J.W., Rickles,N.H.: Malignant papillary cystadenoma lymphomatosum. Report of a case, with a review of the literature. Cancer (Philad.) 18, 851 (1965)

    Google Scholar 

  • Lumerman,H., Freedman,P., Caracciolo,P., Remigio,P.S.: Synchronous malignant mucoepidermoid tumor of the parotid gland and Warthin's tumor in adjacent lymph node. Oral Surg. 39, 953 (1975)

    Google Scholar 

  • Nicholson,G.W.: Studies on tumour formation. Guys hosp. Res. 73, 37 (1923)

    Google Scholar 

  • Pava,S. de la, Knutson,G.H., Mukhtar,F., Pickgren,J.W.: Squamous cell carcinoma arising in Warthin's tumor of the parotid gland. First case report. Cancer (Philad.) 18, 790 (1965)

    Google Scholar 

  • Ruebner,B., Bramhall,J.L.: Malignant papillary cystadenoma lymphomatosum. Arch. Path. (Chicago) 69, 110 (1960)

    Google Scholar 

  • Schmid,K.O., Albrich,W.: Die Bedeutung von Talgzellen und Talgdrüsen für Parotisgeschwülste. Virchows Arch. Abt. A 359, 239 (1973)

    Google Scholar 

  • Seifert,G.: Die Pathologie der Speicheldrüsen im Rahmen der Kollagenkrankheiten. HNO 19, 193 (1971)

    Google Scholar 

  • Seifert,G., Donath,K.: Die Morphologie der Speicheldrüsenerkrankungen. Arch. Oto-Rhino-Laryng. 213, 111 (1976a)

    Google Scholar 

  • Seifert,G., Donath,K.: Classification of the pathohistology of diseases of the salivary glands.—Review of 2600 cases in the salivary gland register. Beitr. path. Anat. 159, 1 (1976b)

    Google Scholar 

  • Smith,J.F., Fesmire,F.M.: The benign papillary cystadenoma lymphomatosum. Oral Surg. 27, 95 (1969)

    Google Scholar 

  • Skorpil,F.: Zur Histologie und Histogenese des papillären Cystadenolymphoms der Parotisdrüse. Frankf. Z. Path. 54, 181 (1939)

    Google Scholar 

  • Ssobolew,L.W.: Zur Kasuistik der Branchiome. Frankf. Z. Path. 11, 462 (1912)

    Google Scholar 

  • Tanaka,N., Chen,W.C.: Mucoepidermoid papillary cystadenoma lymphomatosum. Gann 44, 229 (1953)

    Google Scholar 

  • Thackray,A.C., Lucas,R.B.: Tumors of the major salivary glands. Atlas of tumor pathology, second series, fascicle 10. Washington: Armed Forces Institute of Pathology 1974

    Google Scholar 

  • Thackray,A.C, Sobin,L.H.: Histological typing of salivary gland tumours. Geneva: World Health Organization 1972

    Google Scholar 

  • Thompson,A.S., Bryant,H.C: Histogenesis of papillary cystadenoma lymphomatosum (Warthin's tumor) of the parotid salivary gland. Amer. J. Path. 26, 807 (1950)

    Google Scholar 

  • Tillinger,K.G.: Papillary Cystadenolymphoma. Acta radiol. 28, 241 (1947)

    Google Scholar 

  • Turnbull,A.D., Frazell,E.L.: Multiple tumors of the major salivary glands. Amer. J. Surg. 118,787 (1969)

    Google Scholar 

  • Zechner,G., Albegger,K.W.: Talgdrüsencarcinom der Parotis. Arch. klin. exp. Ohr.-, Nas. u. Kehlk.- Heilk. 205, 119 (1973)

    Google Scholar 

  • Zollinger,H.U.: Radio-Histologie und Radio-Histopathologie. In: Handbuch der Allgemeinen Pathologie, hrsg. F.Büchner, E.Letterer, F.Roulet, Bd. X/1, S. 127ff. Berlin-Göttingen-Heidelberg: Springer 1960

    Google Scholar 

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Authors and Affiliations

  1. Institut für Pathologie der Universität Hamburg, Martinistr. 52, D-2000, Hamburg 20

    G. Seifert, M. Heckmayr & K. Donath

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  1. G. Seifert
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  2. M. Heckmayr
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  3. K. Donath
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Seifert, G., Heckmayr, M. & Donath, K. Carcinome in Papillären Cystadenolymphomen der Parotis Definition und Differentialdiagnose. Z. Krebsforsch. 90, 25–36 (1977). https://doi.org/10.1007/BF00306019

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