Summary
The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significantly increased rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH, 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gallbladder for some carcinogenic substances passing through the liver. The background of this experimental studies are the clinical findings that 10% of patients with carcinoma of the large bowel had previous cholecystectomy.
Zusammenfassung
Die experimentelle Studie gilt dem Koloncarcinom und dem Problem seiner möglichen Entstehung nach einer vorausgegangenen Cholecystektomie. Die Ergebnisse zeigen, daß die 1,2-Dimethylhydrazin (DMH) induzierte Dickdarmcancerogenese der Maus durch die Enrfernung der Gallenblase signifikant gesteigert werden kann. 70% der cholecystektomierten Tiere, denen 10 mal 15 mg/kg DMH subcutan injiziert wurde, hatten nach 20 Wochen einen Dickdarmkrebs. Dagegen wiesen nur 16% der nichtoperierten Tiere (bei sonst gleichen Bedingungen) ein Koloncarcinom auf. Als Ursache des cocarcinogenen Einflusses der Cholecystektomie wird die verstärkte Bildung sekundärer Gallensäuren durch die Darmbakterien, sowie der Fortfall der Resorptionständigkeit der Gallenblase für lebergängige Carcinogene diskutiert. Den klinischen Hintergrund für diese experimentelle Studie bildet die Tatsache, daß 10% aller Dickdarmkrebskranken in der chirurgischen Anamnese eine Cholecystektomie aufweisen.
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References
Berg,J.W., Howell,M.A.: The geographic pathology of bowel cancer. Cancer 34, 807–814 (1974)
Bergmann,F., van der Linden,W.: Bile acid pool size in hamsters during gallstone formation and after cholecystectomy. Z. Ernährungsw. 13, 37–42 (1974)
Cook,J.W., Kennaway,E.L., Kennaway,N.M.: Production of tumors in mice by deoxycholic acid. Nature 145, 627–629 (1940)
Druckrey,H., Preussmann,R., Matzkies,F., Ivankovic,S.: Selektive Erzeugung von Darmkrebs bei Ratten durch 1,2 Dimethylhydrazin. Naturwissenschaften 54, 285–286 (1967)
Druckrey,H.: Produktion of colonic carcinomas by 1,2 Dimethylhydrazines and Azoxyalkanes. In: Carcinoma of the colon and antecedent epithelium (eds. W.J.Burdette), Springfield: C.C.Thomas, pp. 267–279
Fiala,E.: Investigations into the metabolism and mode of action of the colon carcinogen 1,2-Dimethylhydrazine. Cancer 36, 2407–2412 (1975)
Gronemeyer,R., Bässler,R.: Pathologie der Gallenwegserkrankungen. Klinikarzt 4, 361–368 (1975)
Haenzel,W., Correa,P.: Cancer of colon and rectum and adenomatous polyps. A review of epidemiologic findings. Cancer 28, 14–24 (1971)
Hill,M.J.: The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer. Cancer 36, 2387–2400 (1975)
Hill,M.J., Drasar,B.S., Williams,R.E.O., Meade,T.W., Cox,A.G., Simpson,J.E.P., Morson,B.C.: Faecal Bile-acids and clostridia in patients with cancer of the large bowel. Lancet 1975, 535–539
Laqueur,G.L.: The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone. Virchows Arch. path. Anat. 340, 151–163 (1965)
Narisawa,T., Sato,T., Hayakawa,M., Sakuma,A., Nakano,H.: Carcinoma of the colon and rectum of rats by rectal infusion of N-methyl-N′-nitro-N-nitrosoquanidine. Gann 68, 231–234 (1971)
Narisawa,T., Magadia,N.E., Weisburger,H.J., Wynder,E.L.: Promoting effect of bile acids on colon carcinogenesis after intrarectal installation of N-methyl-N′-nitro-N-nitrosoguandine in rats. J. nat. Cancer Inst. 53, 1093–1097 (1974)
Ostrow,J.D.: Absorption by the gallbladder of bile salts, sulfobromophthalein, and iodipamide. J. Lab. clin. Med. 74, 482–494 (1969)
Pomare,E.W., Heaton,K.W.: The effect of cholecystectomie on bile salt metabolism. Gut 14, 753–762 (1973)
Rauscher,F.J.: Major opportunities for the determination of etiologies and prevention of cancers in man. In: Recent advances in human tumor virology and immunology, (eds. W.Nakahara, K.Nishioka, T.Hirayama, Y.Ito), pp. 3–24, Baltimore: Univ. Park Press 1971
Reddy,B.S.: Role of bile metabolites in colon carcinogenesis. Animal models. Cancer 36, 2401–2406 (1975)
Stein,J.J.: Comments on carcinoma of the colon and rectum. Cancer 34, 799–800 (1974)
Werner,B., de Heer,K., Mitschke,H., Knipper,A., Thoran,P., Dahm,K.: Experimental Carcinogenesis in the Resected Colon of the Rat. Z. Krebsforsch. (in press)
Werner,B.: unpublished data
Wiebecke,B., Krey,U., Löhrs,U., Eder,M.: Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch. Abt. A Path. Anat. 360, 179–193 (1973)
Wynder,E.L., Reddy,B.S.: The epidemiology of cancer of the large bowel. Am. J. dig. Dis. 19, 937–946 (1974)
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Werner, B., de Heer, K. & Mitschke, H. Cholecystectomy and carcinoma of the colon. Z. Krebsforsch. 88, 223–230 (1977). https://doi.org/10.1007/BF00305360
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DOI: https://doi.org/10.1007/BF00305360