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Carcinogene Wirkung von 13 Aryldialkyltriazenen an BD-Ratten

Carcinogenic activity of 13 aryldialkyl triazenes in BD-rats

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Summary

Investigation in BD-rats of 13 1-aryl-3,3-dialkyltriazenes demonstrated a potent carcinogenic activity in 10 triazenes. Single dose application in many cases also induced tumors. Malignancies were observed in many organs, a certain preference for brain, nervous system and kidney, however, is evident. The possibility is discussed that triazenes react in vivo according to their chemical reactivity by two different mechanisms, either as diazotising and/or arylating agents or as alkylating agents after enzymatic activation.

Zusammenfassung

Bei der Untersuchung von 13 1-Aryl-3,3-dialkyltriazenen zeigten 10 Triazene starke carcinogene Wirkung an BD-Ratten. Die Tumoren traten in vielen Organen auf, mit gewisser Bevorzugung von Gehirn, Nervensystem und Niere. Es wird diskutiert, daß carcinogene Triazene je nach chemischer Reaktivität entweder als diazotierende und/oder arylierende oder aber nach metabolischer Aktivierung als alkylierende Agentien ihre Wirkung entfalten können.

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Authors and Affiliations

  1. Forschergruppe Präventivmedizin am Max-Planck-Institut für Immunbiologie, Freiburg/Br.

    R. Preussmann,  S. Ivankovic, C. Landschütz, J. Gimmy, E. Flohr & U. Griesbach

  2. Institut für Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum, Kirschnerstraße 6, D-6900, Heidelberg 1, Bundesrepublik Deutschland

    R. Preussmann &  S. Ivankovic

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  1. R. Preussmann
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  2. S. Ivankovic
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  3. C. Landschütz
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  4. J. Gimmy
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  5. E. Flohr
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  6. U. Griesbach
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Herrn Prof. Dr. H. Druckrey zum 70. Geburtstag gewidmet.

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Preussmann, R., Ivankovic, S., Landschütz, C. et al. Carcinogene Wirkung von 13 Aryldialkyltriazenen an BD-Ratten. Z. Krebsforsch. 81, 285–310 (1974). https://doi.org/10.1007/BF00305031

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