Summary
Complementation studies based on mitomycin C sensitivity were performed on somatic cell hybrids between cells of a German patient with Fanconi's anemia and a Turkish, Arab, and Black African proband, respectively. Though the underlying genetic defects are expected to go back to different mutational events, the high rate of induced chromosomal aberrations in the hybrids clearly points to allelic mutations.
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Zakrzewski, S., Sperling, K. Analysis of heterogeneity in Fanconi's anemia patients of different ethnic origin. Hum Genet 62, 321–323 (1982). https://doi.org/10.1007/BF00304547
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DOI: https://doi.org/10.1007/BF00304547