Abstract
The effect of an intravenous injection of thiopental on middle cerebral artery blood velocities was assessed by transcranial pulsed Doppler monitoring in 20 children: ten head-injured patients and ten control subjects. Thiopental induced a moderate but immediate decrease of middle cerebral artery blood velocities in both groups; this variation was significant (P<0.01) and more prolonged in the head-injured than in control patients. Transcranial Doppler ultrasonography thus appears to be suitable for monitoring children in intensive care units and could help to avoid the use of thiopental in patients with low cerebral artery blood flow velocity.
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Aaslid R, Markwalder TM, Nornes H (1982) Non-invasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57:769–774
Auer LM, Leber K, Haselsberger K (1986) Effect of the barbiturate methohexital on cerebral vessels and intra-cranial pressure. Neurosurgery 3:277–282
Bishop CCR, Powell S, Rutt D, Browse NL (1986) Transcranial Doppler measurement of middle cerebral artery blood velocity: a validation study. Stroke 17:913–915
Bode H, Wais U (1988) Dependence of flow velocities in basal cerebral arteries. Arch Dis Child 63:106–111
Bray JM de, Joseph PA, Jeanvoine H, Dauzat M, Maugin D (1987) Transcranial Doppler sonography for blood flow velocity measurements during pharmacological tests. Intern Angiol 6:133–137
Giffin JP, Cottrell JE, Shwiry B, Hartung J, Epstein J, Lim K (1984) Intracranial pressure, mean arterial pressure, and heart rate following midazolam or thiopental in humans with brain tumors. Anesthesiology 605:491–496
Hatano Y, Nakamura K, Mariyama S, Kenjiro M, Noboru T (1989) The contractile response of isolated dog cerebral and extra-cerebral arteries to oxybarbiturates and thiobarbiturates. Anesthesiology 71:80
Kassel NF, Hitchon PW, Gerk MK, Sokoll MD, Hill TR (1980) Alterations in cerebral blood flow oxygen metabolism and electrical activity produced by high dose of thiopental. Neurosurgery 7:598–603
Kirkham FJ, Padayachee TS, Parson S, Seargeant LS, House FR, Golsing RG (1986) Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow. Ultrasound Med Biol 12:15–21
Lindegaard KF, Lundar F, Wiberg J, Sjöberg D, Aaslid R, Nornesh H (1987) Variations in middle cerebral artery flow investigated with non-invasive transcranial blood velocity measurements. Stroke 18:1025–1030
Lundar T, Lindegaard KF, Refsun L, Rian R, Nornes H (1987) Cerebrovascular effects of isoflurane in man. Br J Anesthesiol 59:1208–1213
Nordstrom CK, Messeter K, Sunbarg S, Schalen W, Werner M, Ryding E (1988) Cerebral blood flow, vaso-reactivity and oxygen consumption during barbiturate therapy in severe traumatic brain lesions. J Neurosurg 68:424–435
Piatt JH, Schiff SJ (1984) High dose barbiturate therapy in neurosurgery and intensive care. Neurosurgery 15:427–444
Ringelstein EB, Sievers C, Ecker S, Schneider PA, Otis SK (1988) Non-invasive assessment of CO2-induced cerebral vasomotor response in normal individuals and patients with internal carotid occlusions. Stroke 19:963–969
Sorteberg W, Lindegaard KF, Rootwelt K, Dahl A, Russel D, Nyberg-Hansen R, Normes H (1989) Blood velocity and regional blood flow in defined cerebral artery systems. Acta Neurochir (Wien) 97:47–52
Traeger SM, Henning RJ, Dobkin W, Giannotta S, Weil MH, Weiss M (1983) Hemodynamic effects of pentobarbitural therapy for intracranial hypertension. Crit Care Med 11:697–701
Trautner DA (1986) Barbiturate therapy in acute brain injury. J Pediatr 109:742–746
Ward JD, Becker DP, Milles JD (1985) Failure of prophylactic barbiturate coma in the treatment of severe head injury. J Neurosurg 62:383–388
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de Bray, J.M., Granry, J.C., Monrigal, J.P. et al. Effects of thiopental on middle cerebral artery blood velocities: a transcranial Doppler study in children. Child's Nerv Syst 9, 220–223 (1993). https://doi.org/10.1007/BF00303573
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DOI: https://doi.org/10.1007/BF00303573