Abstract
Vein of Galen aneurysms are uncommon malformations that can be treated with a combination of endovascular embolization and surgery. Since the relevant techniques are new and innovative, their pathologic sequelae are not yet well described. A patient treated with staged embolization over a 15-month period developed evidence of cerebral venous hypertension on angiography. At necropsy, we observed marked myointimal proliferation of the aneurysm wall, dura, and cerebral vessels in addition to severe widespread encephalomalacia, calcinosis, and rare mural thrombi. These vascular changes have not been previously described in cases of vein of Galen aneurysm, and may, in part, be a consequence of embolization therapy.
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Amacher LA, Shillito J Jr (1973) The syndromes and surgical treatment of aneurysms of the great vein of Galen. J Neurosurg 39:89–98
Aminoff MJ, Barnard RO, Logue V (1974) The pathophysiology of spinal vascular malformations. J Neurol Sci 23:255–263
Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Edwards MSB, Hieshima GB (1989) Transfemoral venous embolization of vein of Galen malformations. AJNR 11:643–648
Gold AP, Ransohoff J, Carter S (1964) Vein of Galen malformation. Acta Neurol Scand 40 [Suppl 11]:1–31
Gomez MR, Whitten CF, Nolke A, Bernstein J, Meyer JS (1963) Aneurysmal malformation of the great vein in Galen causing heart failure in early infancy. Report of five cases. Pediatrics 31:400–411
Hirano A, Terry RD (1958) Aneurysm of the vein of Galen. J Neuropathol Exp Neurol 17:424–429
Hoffman HJ, Chuang S, Hendrick B, Humphreys RP (1982) Aneurysms of the vein of Galen. Experience at the Hospital for Sick Children, Toronto. J Neurosurg 57:316–322
Katzenstein A, Askin FB (1990) Surgical pathology of non-neoplastic lung disease. Saunders, Philadelphia
King WA, Wackym PA, Vinuela F, Peacock WJ (1989) Management of vein of Galen aneurysms. Combined surgical and endovascular approach. Child's Nerv Syst 5:208–211
Lasjaunias P, Rodesch G, Terbrugge K, Pruvost P, Devictor D, Comoy J, Landrieu P (1989) Vein of Galen aneurysmal malformations. Report of 36 cases managed between 1982 and 1988. Acta Neurochir (Wien) 99:26–37
Norman MG, Becker LE (1974) Cerebral damage in neonates resulting from arteriovenous malformation of the vein of Galen. J Neurol Neurosurg Psychiatry 37:252–258
Raybaud CA, Strother CM, Hald JK (1989) Aneurysms of the vein of Galen: embryonic considerations and anatomical features relating to the pathogenesis of the malformation. Neuroradiology 31:109–128
Reichman A, Vinters HV (1991) Infantile and neonatal arteriovenous malformations (including vein of Galen aneurysms): a review of three cases. J Neuropathol Exp Neurol 50:355
Stehbens WE (1968) Blood vessel changes in chronic experimental arteriovenous fistulas. Surg Gynecol Obstet 127:327–331
Takashima S, Becker LE (1980) Neuropathology of cerebral arteriovenous malformations in children. J Neurol Neurosurg Psychiatry 43:380–385
Yamashita Y, Nakamura Y, Okudera T, Nishivori A, Mikashima T, Yamaga H, Matsuishi T, Kato H (1990) Neuroradiological and pathological studies on neonatal aneurysmal dilation of the vein of Galen. J Child Neurol 5:45–48
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Reichman, A., Viñuela, F., Duckwiler, G.R. et al. Pathologic findings in a patient with a vein of Galen aneurysm treated by staged endovascular embolization. Child's Nerv Syst 9, 33–38 (1993). https://doi.org/10.1007/BF00301934
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DOI: https://doi.org/10.1007/BF00301934