Summary
The anatomy of the cecum of the laboratory mouse and rat was studied from a comparative standpoint. The topographical situation, mesenterial connections and arterial supply to the ceca were examined macroscopically. Dried specimens were made to study the morphological form and internal structures. Microscopically, at the light, transmission and scanning electron microscopic levels, the characteristic structural aspects of the ceca of both species were observed.
The mucosa of the mouse cecum is arranged in soft-contoured, looped configurations (SEM), which appear as wide-opened crypts light microscopically. The rat has a similar appearance except that the configurations are more densely arranged and the crypts narrower. With TEM, the cecal epithelial cells of both species display typical features of intestinal absorptive cells. The observations made in the rat and mouse are compared with eachother and with other species where detailed information is available.
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References
Abrams GD (1977) Microbial effects on mucosal structure and function. Amer J Clin Nutr 30:1880–1886
Ambuhl S, Williams VJ, Senior W (1979) Effects of caecectomy in the young adult female rat on digestibility of food offered ad libitum and in restricted amounts. Aust J Biol Sci 32:205–213
Bayley HS (1978) Comparative physiology of the hindgut and its nutritional significance. J Anim Sci 46:1800–1803
Behmann H (1973) Vergleichend- und funktionell-anatomische Untersuchungen am Caecum und Colon myomorpher Nagetiere. Z wiss Zool 186:173–294
Björnhag G (1972) Separation and delay of contents in the rabbit colon. Swed J Agr Res 2:125–136
Bond JH, Levitt MD (1976) Fate of soluble carbohydrate in the colon of rats and man. J Clin Invest 57:1158–1164
Bruns P, Hood LF, Seeley HW (1977) Effects of modified starch on the microflora of the small intestine and caecum of rats. Nutr Rep Interntl 15:131–138
Cardell R, Badenhausen S, Porter K (1967) Intestinal triglyceride absorption in the rat. An electron microscopical study. J Cell Biol 34:213–255
Donowitz M, Binder H (1979) Mechanism of fluid and electrolyte secretion in the germ-free rat caecum. Am J Dig Diseases 24:551–559
Gorgas M (1967) Vergleichend-anatomische Untersuchungen am Magen-Darm-Kanal der Sciuromorpha, Hystricomorpha und Caviomorpha (Rodentia) Z wiss Zool 175:237–404
Green M (1959) Anatomy of the rat. Vol XXVII Hafner Publ Co New York
Gustafsson BE, Maunsbach AB (1971) Ultrastructure of the enlarged cecum in germfree rats. Z Zellforsch 120:555–578
Henrikson RC (1973) Ultrastructural aspects of mouse cecal epithelium. Z Zellforsch 140:445–449
Hollander D, Truscott TC (1974) Colonic absorption of vitamin K3. J Lab Clin Med 83:648–656
Hörnicke H, Björnhag G (1980) Coprophagy and related strategies for digesta utilization. In: Ruckebusch Y, Thivend P (ed) Digestive physiology and metabolism in ruminants. Proc 5th Internatl Symp Ruminant Physiol. Clermont-Ferrand 3–7 Sept 1979. MTP Press Ltd. Lancaster England pp 707–730
Janis C (1976) The evolutionary strategy of the Equidae and the origins of rumen and cecal digestion. Evolution 30:757–774
Kostanecki K (1926) Le caecum des vertébrés. Bull Intern Acad Pol Sci Lettres Suppl Cracovie
Leng E (1978) Absorption of inorganic ions and volatile fatty acids in the rabbit caecum. Br J Nutr 40:509–519
Loeschke K (1975) Adaptation der Elektrolyt- und Wasserresorption. Fortschr Med 93:1613–1615
Michaels LE (1977) Glycoprotein containing vesicles in the surface epithelial cells of the ascending colon of the rat. Anat Rec 188:525–533
Perrin MR, Curtis BA (1980) Comparative morphology of the digestive system of 19 species of South African myomorph rodents in relation to diet and evolution. S Afr J Zool 15:22–33
Petith MM, Schedl HP (1976) Intestinal adaptation to dietary calcium restriction: in vivo cecal and colonic calcium transport in the rat. Gastroenterology 71:1039–1042
Rayssiguier Y, Ramsey C (1977) Magnesium absorption in the caecum of rats related to volatile fatty acid production. Ann Rech Vét 8:105–110
Rérat A (1978) Digestion and absorption of carbohydrate and nitrogenous matters in the hindgut of the omnivorous nonruminant animal. J Anim Sci 46:1808–1837
Sakata T, v. Engelhardt W (1979) Mucin layer in the large intestine. Ann Rech Vét 10:485–487
Savage DC, Dubos R, Schaedler RW (1968) The gastrointestinal epithelium and its autochtonous bacterial flora. J Exp Med 127:97–110
Snipes RL (1978) Anatomy of the rabbit cecum. Anat Embryol 155:57–80
Snipes RL (1979a) Anatomy of the cecum of the vole, Microtus agrestis, Anat Embryol 157:181–203
Snipes RL (1979b) Anatomy of the cecum of the dwarf hamster (Phodopus sungorus). Anat Embryol 157:329–346
Thenius E (1969) Stammesgeschichte der Säugetiere. In: von Helmcke, Stark, Wermuth (eds) Handbuch der Zoologie. Vol 8 Part 2 Berlin
Toner PG, Carr KE, Wyburn GM (1971) The digestive system- an ultrastructural atlas and review. Butterworths London
Vorontsov NN (1960) The ways of food specializations and evolution of the alimentary system in Muroidea. Symp Ther Proc Internat Symp Meth Mammal Invest Brno Prag 360–377
Vorontsov NN (1963) Die Ungleichmäßigkeit der Tempi der Umgestaltung der Organe und das Prinzip der Kompensation der Funktionen. Zool J 9:1289–1305
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Snipes, R.L. Anatomy of the cecum of the laboratory mouse and rat. Anat Embryol 162, 455–474 (1981). https://doi.org/10.1007/BF00301871
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DOI: https://doi.org/10.1007/BF00301871