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Magnetic resonance angiography in moyamoya disease

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Abstract

Spontaneous occlusion of the circle of Willis, i.e., moyamoya disease (MMD), is a clinical disease entity angiographically characterized by progressive and bilateral stenosis of the carotid bifurcation, with a hazy collateral network at the base or convexity of the brain. Although the importance of computed tomography (CT) and conventional magnetic resonance (MR) imaging in diagnosing MMD has already been determined, conventional arteriography is still regarded as necessary for definitive diagnosis. Magnetic resonance angiography (MR-A) is a very recent vascular imaging technique which allows noninvasive and direct imaging of vessels without the use of contrast medium. We present four pediatric cases of MMD, evaluated by conventional angiography, CT, MR imaging, and MR-A. Our data demonstrate thatMR-A is successful both in allowing detection of occlusive disease of the basal portion of the internal carotid artery and large branch basal cerebral vessels and demonstrating the collateral vessels at the base of the brain. As a noninvasive procedure, MR-A promises to become a valuable alternative to classical angiography in the diagnosis of MMD.

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References

  1. Aoki T, Matsuzawa H, Houkin K, Kamiyama H, Abe H, Miyasaka K, Saito H (1993) Usefulness and limitation of MR imaging and MR angiography in diagnosis of juvenile moya moya disease. No Shinkei Geka 21: 305–311

    Google Scholar 

  2. Chang KH, Yi JG, Han MH, Kim IO (1990) MR imaging findings of moyamoya disease. J Korean Med Sci 5: 85–90

    Google Scholar 

  3. Creasy JL, Price RR, Presbrey T, Goins D, Partain CL, Kessler RM (1990) Gadolinium-enhanced MR angiography. Radiology 175: 280–283

    Google Scholar 

  4. Demaerel P, Wilms G, Casteels Van Daele M, Marchal G, Van-Fraeyenhoven L, Bosmans H, Casaer P, Baert AL, (1990), Moyamoya. Diagnostic par IRM et angiographie RMN. J Radiol 71:119–123

    Google Scholar 

  5. Edelman RR, Mattle HP, Atkinson DJ, Hoogewoud HM (1990) MR angiography. AJR 154: 937–946

    Google Scholar 

  6. Edelman RR, Mattle HP, Reilly GV, Wentz KU, Liu C, Zhao B (1990) Magnetic resonance imaging of flow dynamics in the circle of Willis. Stroke 21: 56–65

    Google Scholar 

  7. Fujisawa I, Asato R, Mishimura K, Kogashi K, Itoh K, Noma S, Sagoh T, Minami S, Nakano Y, Yonekawa Y (1987) Moyamoya disease. MR imaging. Radiology 164: 103–105

    Google Scholar 

  8. Gordon N, Isler W (1989) Childhood moyamoya disease. Develop Med Child Neurol 31: 98–107

    Google Scholar 

  9. Hankey GJ, Warlow CP, Sellar RJ, (1990) Cerebral angiographic risk in mild cerebrovascular disease. Stroke 21: 209–222

    Google Scholar 

  10. Heiserman JE, Drayer BP, Keller PJ, Fram EK (1992) Intracranial vascular stenosis and occlusion: evaluation with three-dimensional time-of-flight MR angiography. Radiology 185: 667–673

    Google Scholar 

  11. Kurlemann G, Bongartz G, Krings W, Palm DG (1991) Asymptomatic moya-moya syndrome. Diagnosis by EEG and magnetic resonance angiography. Monatsschr Kinderheilkd 139: 235–238

    Google Scholar 

  12. Kurokawa T, Tomita S, Ueda K, Narazaki O, Hanai T, Hasuo K, Matsushima T, Kitamura K (1985) Prognosis of occlusive disease ofthe circle of Willis (moyamoya disease) in children. Pediatr Neurol 1: 274–277

    Google Scholar 

  13. Kuwabara Y, Ichiya Y, Otsuka M, Tahara T, Gunasekera R, Hasuo K, Masuda K, Matsushima T, Fukui M (1990) Cerebral hemodynamic change in the child and the adult with moyamoya disease. Stroke 21: 272–277

    Google Scholar 

  14. Laub GA, Kaiser WA (1989) MR angiography with gradient motion refocusing. J Comput Assist Tomogr 12: 377–382

    Google Scholar 

  15. Marchal G, Bosmans H, Van Fraeyenhoven L, Wilms G, Van Hecke P, Plets C, Baert AL (1990) Intracranial vascular lesions: optimization and clinical evaluation of three-dimensional time-of-flight MR angiography. Radiology 175: 443–448

    Google Scholar 

  16. Masaryk TJ, Modic MT, Ross JS, Ruggieri PM, Laub GA (1989) Intracranial circulation: preliminary clinical results with three-dimensional (volume) MR angiography. Radiology 171: 793–799

    Google Scholar 

  17. Matsushima Y, Aoyagi M, Niimi Y, Masaoka H, Ohno K (1990) Symptoms and their pattern of progression in childhood moyamoya disease. Brain Dev 12: 784–789

    Google Scholar 

  18. Nishimoto A (1979) Moyamoya disease. Neurol Med Chir 19: 221–228

    Google Scholar 

  19. Ohashi K, Fernandez Ulloa M, Hall LC (1992) SPECT, magnetic resonance and angiographic features in a moyamoya patient before and after external-tointernal carotid artery by pass. J Nucl Med 33: 1692–1695

    Google Scholar 

  20. Rolak LA, Rokey R (1986) Magnetic resonance imaging in moyamoya disease. J Clin Neurol 1: 67–70

    Google Scholar 

  21. Ross JS, Masaryk TJ, Modic MT, Harik SI Wiznitzer M, Selman WR (1989) Magnetic resonance angiography of the extracranial carotid arteries and intracranial vessels: a review. Neurology 39: 1369–1376

    Google Scholar 

  22. Sato K, Shimoji T (1992) Moyamoya disease. In: Raimondi AJ, Choux M, Di Rocco C (eds) Cerebrovascular diseases in children. Springer. New York Berlin Heidelberg, pp 227–243

    Google Scholar 

  23. Sato S, Shibuya H, Matsushima Y, Suzuki S (1988) Analysis of the angiographic findings in cases of childhood moyamoya. Neuroradiology 30: 111–119

    Google Scholar 

  24. Sato H, Sato N, Tamaki N, Matsumoto S (1990) Chronic low-perfusion state in children with moyamoya disease following revascularization. Child's Nerv Syst 6: 166–171

    Google Scholar 

  25. Sunaga Y, Fujinaga T, Ohtsuka T (1992) MRI findings of moyamoya disease in children. No To Hattatsu 24: 375–379

    Google Scholar 

  26. Suzuki J, Takaku A (1969) Cerebrovascular moyamoya disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol 20: 288–299

    Google Scholar 

  27. Suzuki J, Kodama N (1983) Moyamoya disease. A review. Stroke 14: 104–109

    Google Scholar 

  28. Takahashi M, Miyauchi T, Kowada M (1980) Computed tomography of moyamoya disease: demonstration of occluted arteries and collateral vessels as important diagnostic signs. Radiology 134: 671–676

    Google Scholar 

  29. Takeuchi S, Tanaka R, Ishii R, Tsuchida T, Kobayashi K, Arai H (1985) Cerebral hemodynamics in patients with moyamoya disease. A study of regional cerebral blood flow by the 133Xe inhalation method. Surg Neurol 23: 468–474

    Google Scholar 

  30. Yamada I, Matsushima Y, Suzuki S, (1992) Moyamoya disease: diagnosis with three-dimensional time-of-flight MR angiography. Radiology 184: 773–778

    Google Scholar 

  31. Zimmerman RA, Bogdan A, Bilaniuk LT (1992) Pediatric MR angiography of the central nervous system. Riv Neuroradiol 5 [Suppl 1]: 121–126

    Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, University of Padua, Via Giustiniani,3, I-35128, Padova, Italy

    P. A. Battistella, C. Carollo & P. A. Pellegrino

  2. Department of Pediatrics, University of Ferrara, Via Savonarola, 9, 1-44100, Ferrara, Italy

    S. Soriani & P. Scarpa

Authors
  1. P. A. Battistella
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  2. C. Carollo
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  3. P. A. Pellegrino
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  4. S. Soriani
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  5. P. Scarpa
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Battistella, P.A., Carollo, C., Pellegrino, P.A. et al. Magnetic resonance angiography in moyamoya disease. Child's Nerv Syst 11, 329–334 (1995). https://doi.org/10.1007/BF00301664

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  • DOI: https://doi.org/10.1007/BF00301664

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