Abstract
Seven patients with Cushing's syndrome secondary to adrenocortical tumors were studied using 131I-19-iodocholesterol. The diagnosis of all cases were verified histologically. In three cases with adenoma the uptake of the tracer was in the tumor only, while the two patients with adrenocortical carcinoma failed to show adrenal accumulation of the labelled compound.
In two patients there was a hyperplasia-like scintigraphic pattern, while the stimulation and suppression biochemical tests suggested adrenal tumor. One of these cases was verified as a mixed form (adenoma plus hyperplasia), and the tumor bearing gland was significantly larger on the scan which helped the preoperative localization. In the other case, verified as bilateral multiple adrenocortical adenomas, the autonomus function of both adrenals was proved by dexamethasone suppression scanning. It seens reasonable to use the latter as an adjunctive diagnostic procedure in patients where there is a discrepancy between the standart scintiscan and the biochemical indexes of adrenal hyperfunction.
Similar content being viewed by others
References
Anderson, B.G., Beierwaltes, W.H.: Adrenal imaging with radiocholesterol in the diagnosis of adrenal disorders. Adv. Intern. Med. 19, 327–343 (1974)
Beierwaltes, W.H., Lieberman, L.M., Ansari, A.A., Nishiyama, H.: Visualization of human adrenal glands in vivo by scintillation scanning. JAMA, 216, 275–277 (1971)
Conn, J.W., Morita, R., Cohen, E.L., Beierwaltes, W.H., McDonald, W.J., Herwin, K.R.: Primary aldosteronism. Photoscanning of tumors after administration of 131I-19-iodocholesterol. Arch. Intern. Med. 129, 417–425 (1972)
Jorgensen, H., Norman, N., Sundsfjord, J.A.: Scintigraphy with 131I-19-iodocholesterol in adrenal disease: an evaluation. Nor-Acta Med. Scand. 197, 345–351 (1975)
Lieberman, L.M., Beierwaltes, W.H., Conn, J.W., Ansari, A.N., Nishiyama, H.: Diagnosis of adrenal disease by visualization of human adrenal glands with 131I-19-iodocholesterol. New Engl. J. Med. 285, 1387–1393 (1971)
Moses, D.C., Schteingart, D.E., Sturman, M.F., Beierwaltes, W.H., Ice, R.D.: Efficacy of radiocholesterol imaging of the adrenal glands in Cushing's syndrome. Surg. Gynecol. Obstet. 139, 201–204, (1974)
Schteingart, D.E., Conn, J.W., Lieberman, L.M., Beierwaltes, W.H.: Persistent or recurrent Cushing's syndrome after “total” adrenalectomy. Arch. Intern. Med. 130, 384–386 (1972)
Troncone, L., Galli, G. Salvo, D., Barbarino, A., Bonomo, L.: Radioisotopic study of the adrenal glands using 131I-19-iodocholesterol. Br. J. Radiol. 50, 340–349 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barliev, G.B. Adrenal scintigraphy with 131I-19-iodocholesterol in the diagnosis of Cushing's syndrome associated with adrenal tumor. Eur J Nucl Med 4, 449–451 (1979). https://doi.org/10.1007/BF00300844
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00300844