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Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines

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Summary

The natural resistance to doxorubicin of 15 human renal carcinoma cell lines was analyzed and compared to proliferative activity and expression of P-glycoprotein. We found a significant negative correlation between proliferative activity and natural resistance to doxorubicin, as well as between proliferative activity and the expression of P-glycoprotein. A positive correlation between resistance and expression of P-glycoprotein was found.

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Authors and Affiliations

  1. Institute of Experimental Pathology, German Cancer Research Center, Heidelberg, FRG

    T. Efferth, H. Löhrke & M. Volm

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  1. T. Efferth
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  2. H. Löhrke
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  3. M. Volm
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Efferth, T., Löhrke, H. & Volm, M. Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines. Urol. Res. 18, 309–312 (1990). https://doi.org/10.1007/BF00300777

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