Skip to main content
SpringerLink
Log in

Effect of soft segment on degradation kinetics in polyethylene glycol/poly(l-lactide) block copolymers

  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Summary

The hydrolytic degradation of polyethylene glycol(PEG)/poly (L-lactide)(PLLA) copolymers with various PEG wt% contents at 37°C and pH=7 was studied by differential scanning calorimetry(DSC) and gel permeation chromatography(GPC). The effect of PEG contents in PEG/PLLA copolymers on the crystalline morphology and hydrolytic degradation rate was investigated. Due to the hydrophilic PEG segments in PEG/PLLA copolymers, the exothermic recrystallization and the shoulder portion of melting endotherm appear immediately following the hydrolysis of copolymers. Moreover, after a period of hydrolysis of 100 h. the molecular weight distribution turn to a bimodal shape from a unimodal in the original, and the polydispersity becomes greater with a value from 1.5 up to 5, which are not observed for PLLA homopolymer. The rate constants of hydrolysis for the first-order auto-catalytic kinetics, increase with the PEG content over 0 to 18.3 wt%, ranging from 1 to 6x10-4hr-1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E.J. Frazza, and E.E. Schmitt, J. Biomed. Mater. Res. Symp., 1, 43 (1971)

    Google Scholar 

  2. A.D. Schwode, D.L. Wise, K.W. Sell, D.P. Dressler, and W.A. Skornick, J. Biomed. Mater. Res., 11, 489(1971)

    Google Scholar 

  3. R.K. Kulkarni, K.C. Pani, C. Neuman, and F. Leonard, J. Biomed. Mater. Res., 5, 169(1971)

    Google Scholar 

  4. A.M. Reed, and D.K. Gilding, Polymer, 22, 494(1981)

    Google Scholar 

  5. J.F. Oslon, S. Robert, and D.B. Osbon, Oral Surg., 43, 836(1977)

    Google Scholar 

  6. Y. Cha, and C.G. Pitt, J. Controlled Release, 7, 69(1988)

    Google Scholar 

  7. Y. Cha, and C.G. Pitt, Biomater., 11, 108(1990)

    Google Scholar 

  8. R.K. Chang, J.C. Price, and C.W. Whitworth, Pharm. Technol, 10, 24(1986)

    Google Scholar 

  9. P. Dubois, R. Jerome, and P. Teyssie, Macromolecules, 24, 977(1991)

    Google Scholar 

  10. Y. Kimura, Y. Matsuzaki, H. Yamane, and T. Kitao, Polymer, 30, 1342(1989)

    Google Scholar 

  11. D. Cohn, and H. Younes, J. Biomed. Mater. Res., 22, 993(1988)

    Google Scholar 

  12. K.J. Zhu, X.G. Lin, and S.L. Yang, J. Appl. Polym. Sci. 39 1(1990)

    Google Scholar 

  13. H. Younes, and D. Cohn, in “Polymers in Medicine 111”, ed. by chiellini & Elsevier, pp.27,(1988)

  14. K.J. Zhu, B.H. Song, and S.L. Yang, J. Polym. Sci., part A: Polym. Chem. 27, 2151(1989)

    Google Scholar 

  15. L.H. Tung, J. Appl. Polym. Sci., 24, 953(1979)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Textile Engineering, National Taiwan Institute of Technology, 107, Taipei, Taiwan Republic of China

    David Shiaw-Guang Hu & Hsin-Jiant Liu

Authors
  1. David Shiaw-Guang Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hsin-Jiant Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shiaw-Guang Hu, D., Liu, HJ. Effect of soft segment on degradation kinetics in polyethylene glycol/poly(l-lactide) block copolymers. Polymer Bulletin 30, 669–676 (1993). https://doi.org/10.1007/BF00300035

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00300035

Keywords

Search

Navigation