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A critical evaluation of HL-A phenotype and genotype frequencies in a large German population determined by platelet complement fixation and lymphocytotoxicity

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Summary

1047 healthy, random blood donors were typed independently for HL-A antigens by platelet complement fixation and lymphocytotoxicity. The results of both methods were analyzed statistically and the gene frequencies calculated. The gene frequencies were: first HL-A locus: 1: 0.1277–0.1316; 2: 0.3018–0.3053; 3: 0.1411–0.1456; 9: 0.1061–0.1088; 10: 0.0540–0.0564; 11: 0.0381–0.0416; W28: 0.0096–0.0271; W32: 0.0365–0.0469; second HL-A locus: 5: 0.0613–0.0649; 7: 0.1367–0.1401; 8: 0.0716–0.0920; 12: 0.0383–0.0903; 13: 0.0357–0.0371; W5: 0.0786–0.0844; W10: 0.0594–0.0620; W14: 0.0280–0.0315; W15: 0.0650–0.0722; W17: 0.0399; W18: 0.0241–0.0374; W22: 0.0037–0.0161; W27: 0.0406–0.0532; W21: 0.0329–0.0428. The discrepancies of typing results are discussed and their practical importance for paternity serology is stressed.

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References

  1. Bertrams, J., Kuwert, E., Böhme, U.: HL-A phenotype and gene frequencies in the German Ruhr area population. Europ. J. Immunol. 1, 306–309 (1971)

    Article  CAS  Google Scholar 

  2. Colombani, J., D'Amaro, J., Gabb, B., Smith, G., Svejgaard, A.: International agreement on a microtechnique of platelet complement fixation. Transplant. Proc. 3, 121 (1971)

    CAS  PubMed  Google Scholar 

  3. Colombani, J.: Platelet complement fixation. In: Joint report of the Fifth International Histocompatibility Workshop. Histocompatibility Testing 1972, pp. 646–647. Copenhagen: Munksgaard 1973

    Google Scholar 

  4. Dausset, J.: The genetics of the HL-A system and its implications in transplantation. Vox Sang. (Basel) 20, 97–108 (1971)

    Article  CAS  Google Scholar 

  5. Heinrich, D., Mueller-Eckhardt, Ch., Czitrom, A.: Elution of HL-A specific antibodies from platelets. Vox Sang. (Basel) 27, 310 (1974)

    Article  CAS  Google Scholar 

  6. Kissmeyer-Nielsen, F., Thorsby, E.: Human transplantation antigens. Transplant. Rev. 4 (1970)

  7. Mayr, W.: Personal communication

  8. Mueller-Eckhardt, Ch., Heinrich, D., Rothenberg, V.: Studies on cross-reactive HL-A antibodies by elution with platelets. Tissue Antigens 2, 436–446 (1972)

    Article  CAS  Google Scholar 

  9. Terasaki, P. I., McClelland, J. D.: Microdroplet assay of human serum cytotoxins. Nature (Lond.) 204, 998–1000 (1964)

    Article  CAS  Google Scholar 

  10. Van Rood, J. J., Freudenberg, J., van Leeuwen, A., Schippers, H. M. A., Zweerus, R., Terpstra, J. L.: Eurotransplant technical paper 1970 (loc. cit. 1)

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Authors and Affiliations

  1. Department of Clinical Immunology and Blood Transfusion, University of Giessen, Giessen, West Germany

    Christian Mueller-Eckhardt, Dieter Heinrich, Karin Mersch-Baumert, Andreas Czitrom & Peter Walker

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  1. Christian Mueller-Eckhardt
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  2. Dieter Heinrich
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  3. Karin Mersch-Baumert
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  4. Andreas Czitrom
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  5. Peter Walker
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Supported by the Deutsche Forschungsgemeinschaft (Mu 277/5).

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Mueller-Eckhardt, C., Heinrich, D., Mersch-Baumert, K. et al. A critical evaluation of HL-A phenotype and genotype frequencies in a large German population determined by platelet complement fixation and lymphocytotoxicity. Hum Genet 24, 319–324 (1974). https://doi.org/10.1007/BF00297596

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