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Wilmore DW (1976) Carbohydrate metabolism in trauma. Clin Endocrinol Metabol 5: 731–745
Halter JB, Pflug AE, Porte D Jr (1977) Mechanism of plasma catecholamine increases during surgical stress in man. J Clin Endocrinol Metab 45: 936–944
Christensen NJ, Videback J (1974) Plasma catecholamines and carbohydrate metabolism in patients with acute myocardial infarction. J Clin Invest 54: 278–286
Waldhäusl W, Kleinberger G, Korn A, Dudczak R, Bratusch-Marrain P, Nowotny P (1979) Severe hyperglycemia: effects of rehydration on endocrine derangements and blood glucose concentration. Diabetes 28: 577–584
Waldhäusl W, Kleinberger G, Kastner G, Komjati M, Korn A, Nowotny P, Bratusch-Marrain P (1979) Glucose utilization: effects of hyperosmolality and counter-regulatory hormones. Studies in vivo and in vitro. Acta Endocrinol (Kbh), Suppl. 225: 405
DeFronzo RA, Beckles AD (1979) Glucose intolerance following chronic metabolic acidosis in man. Am J Physiol 5: E328-E334
Schade D, Eaton R (1977) The controversy concerning counterregulatory hormone secretion: A hypothesis for the prevention of diabetic ketoacidosis? Diabetes 26: 596–599
Müller WA, Faloona GR, Unger RH (1973) Hyperglucagonemia in diabetic ketoacidosis. Am J Med 54: 52–57
Unger RH (1965) High growth-hormone levels in diabetic ketoacidosis: A possible cause of insulin resistance. JAMA 191: 149–151
Gerich JE, Langlois M, Noacco C, Lorenzi M, Karam JH, Forsham PH (1976) Comparison of the suppressive effects of elevated plasma glucose and free fatty acid levels on glucagon secretion in normal and insulin dependent diabetic subjects: Evidence for selective alpha-cell insensitivity to glucose in diabetes mellitus. J Clin Invest 58: 320–325
Hansen AaP, Johansen K (1970) Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normal and juvenile diabetics. Diabetologia 6: 27–33
Christensen NJ (1974) Plasma norepinephrine and epinephrine in untreated diabetics, during fasting and after insulin administration. Diabetes 23: 1–8
Gerich JE, Schneider V, Dippe SE, Langlois M, Noacco C, Karam JH, Forsham PH (1979) Characterization of the glucagon response to hypoglycemia in man. J Clin Endocrinol Metab 38: 77–82
Benson JW Jr, Johnson DG, Palmer JP, Werner PL, Ensinck JW (1977) Glucagon and catecholamine secretion during hypoglycemia in normal and diabetic man. J Clin Endocrinol Metab 44: 459–464
Landon J, Wynn V, James VHT (1963) The adrenocortical response to insulin-induced hypoglycaemia. J Endocrinol 27: 183–192
Raskin P, Unger RH (1977) Effects of exogenous hyperglucagonemia in insulin-treated diabetics. Diabetes 26: 1034–1039
Luft R, Cerasi E (1968) Human growth hormone as a regulator of blood glucose concentration and as a diabetogenic substance. Diabetologia 4: 1–9
Perley M, Kipnis DM (1966) Effects of glucocorticoids on plasma insulin. N Engl J Med 274: 1237–1241
Baker L, Kaye R, Haque N (1969) Metabolic homeostasis in juvenile diabetes mellitus. Increased ketone responsiveness to epinephrine. Diabetes 18: 421–427
Liljenquist JE, Bomboy JD, Lewis SB, Sinclair-Smith BC, Felts PW, Lacy WW, Crofford OB, Liddle GW (1974) Effects of glucagon on lipolysis and ketogenesis in normal and diabetic man. J Clin Invest 53: 190–197
Gerich J, Lorenzi M, Bier D, Tsalikian E, Schneider V, Karam J, Forsham P (1976) Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. J Clin Invest 57: 875–884
Schade DS, Eaton RP (1978) Modulation of basal ketone body concentration by cortisol in diabetic man. J Clin Endocrinol Metab 47: 519–528
Schade DS, Eaton RP (1978) The regulation of plasma ketone body concentration by counter-regulatory hormones in man. II. Effects of growth hormone in diabetic man. Diabetes 27: 916–924
Willms B, Böttcher M, Wolters V, Sakamoto N, Söling HD (1969) Relationship between fat and ketone body metabolism in obese and nonobese diabetics and nondiabetics during norepinephrine infusion. Diabetologia 5: 88–96
Raskin P, Unger RH (1978) Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes. New Engl J Med 299: 433–436
Gerich J, Lorenzi M, Bier D, Schneider V, Tsalikian E, Karam J, Forsham P (1975) Prevention of human diabetic ketoacidosis by somatostatin: Evidence for an essential role of glucagon. N Engl J Med 292: 985–989
Barnes AJ, Kohner EM, Bloom SR (1978) Importance of pituitary hormones in aetiology of diabetic ketoacidosis. Lancet 1: 1171–1174
Felig P, Sherwin RS, Soman V, Wahren J, Hendler R, Sacca L, Eigler N, Goldberg D, Walesky M (1979) Hormonal interactions in the regulation of blood glucose. Rec Progr Horm Res 35: 501–529
Galbraith HJB, Ginsburg J, Paton A (1960) Decreased response to intra-arterial insulin in acromegaly. Diabetes 9: 459–465
Greenberg EJ, Grayzel J, Ray BS, Pearson OH (1958) Influence of human growth hormone on carbohydrate metabolism in man. Clin Res 6: 242–243
Greenwood FC, Landon J (1966) Growth hormone secretion in response to stress in man. Nature 210: 540–541
Schalch DS (1967) The Influence of physical stress and exercise on growth hormone and insulin secretion in man. J Lab Clin Med 69: 256–269
Honda Y, Takahashi K, Takahashi S, Azumi K, Irie M, Sakuma M, Tsushima T, Shizuma K (1969) Growth hormone secretion during nocturnal sleep in normal subjects. J Clin Endocr 29: 20–29
Bratusch-Marrain P, Smith D, DeFronzo RA (1982) The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metabol 55: 973–982
MacGorman LR, Rizza RA, Gerich JE (1981) Physiologic concentrations of growth hormone exert insulin-like and insulin antagonistic effects on both hepatic and extrahepatic tissues in man. J Clin Endocrinol Metabol 53: 556–559
Bratusch-Marrain P, Waldhäusl W, Gasic S, Korn A, Nowotny P (1980) Oral glucose tolerance test: effect of different glucose loads on splanchnic carbohydrate and substrate metabolism in healthy man. Metabolism 29: 289–295
Bratusch-Marrain P, Waldhäusl W, Grubeck-Loebenstein B, Korn A, Vierhapper H (1980) Die Bedeutung von Glukagon, Somatotropin, Cortisol und Adrenalin als Insulinantagonisten bei Diabetes mellitus. Verh Dtsch Ges Inn Med 87: 83–86
Feldman JM, Plonk JW, Bivens CH (1975) The role of cortisol and growth hormone in the counter-regulation of insulin-induced hypoglycemia. Horm Metab Res 7: 378–381
Somogyi M (1959) Diabetogenic effect of hyperinsulinism. Am J Med 26: 192–198
Unger R (1978) Role of glucagon in the pathogenesis of diabetes. The status of controversy. Metabolism 27: 1691–1709
Felig P, Wahren J, Hendler R (1976) Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man. J Clin Invest 58: 761–765
Bratusch-Marrain P, Björkman O, Hagenfeldt L, Waldhäusl W, Wahren J (1979) Influence of arginine on splanchnic glucose metabolism in man. Diabetes 28: 126–131
Sherwin RS, Fisher M, Hendler R, Felig P (1976) Hyperglucagonemia and blood glucose regulation in normal, obese, and diabetic subjects. N Engl J Med 294: 455–461
Clarke WL, Santiago JV, Kipnis DM (1978) The effect of hyperglucagonemia on blood glucose concentrations and on insulin requirements in insulin-requiring diabetes mellitus. Diabetes 27: 649–652
Liljenquist JE, Rabin D (1979) Lack of a role for glucagon in the disposal of an oral glucose load in normal man. J Clin Endocrinol Metab 49: 937–939
Bratusch-Marrain P, Waldhäusl W, Grubeck-Loebenstein B, Korn A, Vierhapper H, Nowotny P (1981) The role of ‘diabetogenic’ hormones on carbohydrate and lipid metabolism following oral glucose loading in insulin dependent diabetics: Effects of acute hormone administration. Diabetologia 21: 387–393
Gerich J, Lorenzi M, Tsalikian E, Bohannon N, Schneider V, Karam J, Forsham P (1976) Effects of acute insulin withdrawal and administration on plasma glucagon response to intravenous arginine in insulin-dependent diabetic subjects. Diabetes 25: 955–960
Rizza R, Verdonk C, Miles J, Service F, Gerich J (1979) Effect of intermittent endogenous hyperglucagonemia on glucose homeostasis in normal and diabetic man. J Clin Invest 63: 1119–1123
Gerich JE, Schultz TA, Lewis SB, Karam JH (1977) Clinical evaluation of somatostatin as a potential adjunct to insulin in the management of diabetes mellitus. Diabetologia 13: 537–544
Wahren J, Felig P (1976) Influence of somatostatin on carbohydrate disposal and absorption in diabetes mellitus. Lancet 2: 2213–1216
Bratusch-Marrain P, Vierhapper H, Grubeck-Loebenstein B, Waldhäusl W, Nowotny P (1981) Antidiabetic action of somatostatin after oral glucose loading: due to suppression of glucagon and growth hormone or of intestinal carbohydrate absorption? Horm Metab Res 13: 305–309
Waldhäusl W, Bratusch-Marrain P, Dudczak R, Deutsch E (1977) The diabetogenic action of somatostatin in healthy subjects and in maturity onset diabetics. J Clin Endocrinol Metabol 44: 876–883
Garber AJ, Cryer PE, Santiago JV, Raymond MW, Pagliara AS, Kipnis DM (1976) The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man. J Clin Invest 58: 7–15
Rizza R, Cryer PE, Haymond M, Gerich J (1980) Adrenergic mechanisms for the effects of epinephrine and glucose production and clearance in man. J Clin Invest 65: 682–689
Porte D (1967) A receptor mechanism for the inhibition of insulin release by epinephrine in man. J Clin Invest 46: 86–94
Deibert DC, DeFronzo RA (1980) Epinephrine-induced insulin resistance in man. J Clin Invest 65: 717–721
Waldhäusl W, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P (1982) Failure of epinephrine to inhibit insulin release stimulated by OGTT (75 g). Diabetes 31 (Suppl 2): 139A
Schade DS, Eaton RP (1978) The metabolic response to norepinephrine in normal versus diabetic man. Diabetologia 15: 433–439
Cohen AS, Vance VK, Runyan JW Jr, Hurwitz D (1960) Diabetic acidosis: An evaluation of the cause, course and therapy of 73 cases. Ann Intern Med 52: 55–86
Hinkle LE Jr, Conger GB, Wolf S (1950) Studies on diabetes mellitus: The relation of stressful life situations to the concentration of ketone bodies in the blood of diabetic and non-diabetic humans. J Clin Invest 29: 754–769
Rizza RA, Cryer PE, Gerich JE (1979) Role of glucagon, catecholamines, and growth hormone in human glucose counter-regulation. Effects of somatostatin and combined αand β-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest 64: 62–71
Boden G, Reichard GA, Hoeldtke RD, Rezvani I, Owen OE (1981) Severe insulin-induced hypoglycemia associated with deficiencies in the release of counter-regulatory hormones. New Engl J Med 305: 1200–1205
Pupo AA, Wajchenberg BL, Schnaider J (1966) Carbohydrate metabolism in hyperadrenocorticism. Diabetes 15: 24–29
Shamoon H, Soman V, Sherwin RS (1980) The influence of acute physiological increments of cortisol on fuel metabolism and insulin binding to monocytes in normal humans. J Clin Endocrinol Metab 50: 495–501
Rizza RA, Mandarino LJ, Gerich JE (1982) Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a post-receptor defect of insulin action. J Clin Endocrinol Metab 54: 131–138
DePirro R, Bertoli A, Fusco A, Testa I, Greco AV, Lauro R (1980) Effect of dexamethasone and cortisol on insulin receptors in normal human male. J Clin Endocrinol Metabol 51: 503–507
Shamoon H, Hendler R, Sherwin RS (1980) Altered responsiveness to cortisol, epinephrine, and glucagon in insulin-infused juvenile-onset diabetics. Diabetes 29: 284–291
Wajchenberg BL, Cesar FP, Leme CE, Souza ITT, Pieroni RR, Mattar E (1978) Effects of adrenergic stimulating and blocking agents on glucose-induced insulin responses in human thyrotoxicosis. Metabolism 27: 1715–1720
Doar JWH, Stamp TCB, Wynn V, Path FC, Audhya TK (1969) Effects of oral and intravenous glucose loading in thyrotoxicosis. Studies of plasma glucose, free fatty acid, plasma insulin and blood pyruvate levels. Diabetes 18: 633–639
Kabadi UM, Eisenstein AB (1980) Glucose intolerance in hyperthyroidism: role of glucagon. J Clin Endocrinol Metab 50: 392–396
Landgraf R, Landgraf-Leurs MMC, Weissmann A, Hörl R, von Werder K, Scriba PC (1977) Prolactin: a diabetogenic hormone. Diabetologia 13: 99–104
Bratusch-Marrain P, Kleinberger G, Korn A, Waldhäusl W (1980) Prolactin in diabetic precoma. Endokrinologie 75: 235–239
Gattereau A, Bielmann P, Durivage J, Larochelle P (1977) Hyperglycaemic effect of synthetic salmon calcitonin. Lancet 2: 1076–1077
Passariello N, Giugliano D, Sgambato S, Torella R, D'Onofrio F (1981) Calcitonin, a diabetogenic hormone? J Clin Endocrinol Metab 53: 318–323
Kinsell LW, Margen S, Michaels GD, Reiss R, Frantz R, Carbone J (1951) Studies in fat metabolism. III. The effect of ACTH, of cortisone, and of other steroid compounds upon fasting-induced hyperketonemia and ketonuria. J Clin Invest 30: 1491–1498
Alberti K, Christensen N, Iversen J, Orskov H (1975) Role of glucagon and other hormones in development of diabetic ketoacidosis. Lancet 1: 1307–1311
Miles JM, Rizza RA, Hamond MW, Gerich JE (1980) Effects of acute insulin deficiency on glucose and ketone body turnover in man. Evidence for the primacy of overproduction of glucose and ketone bodies in the genesis of diabetic ketoacidosis. Diabetes 29: 926–930
Waldhäusl W (1979) Treatment of diabetes mellitus: Pathophysiological aspects and state of the art. In: Waldhäusl W (ed). International Congress Series 500, Excerpta Medica, Amsterdam, p 10–22
Waldhäusl W, Kleinberger G (1980) Acute treatment of diabetic coma. In: Podolsky S, Viswanathan M (eds), Secondary diabetes: the spectrum of the diabetic syndromes. Raven Press, New York, pp 215–230
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Bratusch-Marrain, P.R. Insulin-counteracting hormones: Their impact on glucose metabolism. Diabetologia 24, 74–79 (1983). https://doi.org/10.1007/BF00297384
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DOI: https://doi.org/10.1007/BF00297384