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Effects of high-energy shock waves combined with biological response modifiers or Adriamycin on a human kidney cancer xenograft

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Summary

We have studied the effect of high-energy shock waves (HESW) alone or in combination with biological response modifiers (BRMs) or Adriamycin on the growth of the NU-1 human kidney cancer xenograft. When HESW are administered repeatedly (four sessions of 800 shock waves on days 0, 2, 4 and 6) a prolonged delay in tumor growth was found compared with that following a single administration. This effect was temporary, and several days after stopping the HESW administration the tumor regained its original growth potential (same doubling time). Tumor growth was suppressed for a longer period by the combination of 4 sessions of HESW and a single administration of Adriamycin, 5 mg/kg. Combination of HESW treatment with interferon alpha (5.0 ng/g body weight, three times/week) and tumor necrosis factor alpha (500 ng/g body weight, 5 days/week) s.c. around the tumor resulted in a complete cessation of tumor growth. While Adriamycin had an additive effect on HESW treatment, the combination with BRMs was highly synergistic.

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Authors and Affiliations

  1. Department of Urology, St. Radboud University Hospital, Nijmegen, The Netherlands

    G. O. N. Oosterhof, G. A. H. J. Smiths, J. E. deRuyter, J. A. Schalken & F. M. J. Debruyne

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  1. G. O. N. Oosterhof
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  2. G. A. H. J. Smiths
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  3. J. E. deRuyter
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  4. J. A. Schalken
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  5. F. M. J. Debruyne
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Oosterhof, G.O.N., Smiths, G.A.H.J., deRuyter, J.E. et al. Effects of high-energy shock waves combined with biological response modifiers or Adriamycin on a human kidney cancer xenograft. Urol. Res. 18, 419–424 (1990). https://doi.org/10.1007/BF00297376

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  • DOI: https://doi.org/10.1007/BF00297376

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