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The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase

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Abstract

We have identified a Caenorhabditis elegans homolog of p34cdc2 kinase. The C. elegans homolog, ncc-1, is ∼-60% identical to p34cdc2 of Homo sapiens. When expressed from a constitutive yeast promoter, ncc-1 is capable of complementing a conditional lethal mutation in the CDC28 gene of Saccharomyces cerevisiae, indicating that this C. elegans homolog can properly regulate the cell cycle.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, 91125, Pasadena, CA, USA

    Hiro Mori, Robert E. Palmer & Paul W. Sternberg

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  1. Hiro Mori
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  2. Robert E. Palmer
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  3. Paul W. Sternberg
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Communicated by J. A. Campos-Ortega

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Mori, H., Palmer, R.E. & Sternberg, P.W. The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase. Molec. Gen. Genet. 245, 781–786 (1994). https://doi.org/10.1007/BF00297285

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  • DOI: https://doi.org/10.1007/BF00297285

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